Identification, replication, and fine-mapping of loci associated with adult height in individuals of African ancestry

PLoS Genetics

Volumn 7, Issue 10, 2011, Pages

  N'Diaye, Amidou ^a   Chen, Gary K ^b   Palmer, Cameron D ^c,d   Ge, Bing ^e   Tayo, Bamidele ^f   Mathias, Rasika A ^g   Ding, Jingzhong ^h   Nalls, Michael A ⁱ   Adeyemo, Adebowale ^j   Adoue, Véronique ^e   Ambrosone, Christine B ^k   Atwood, Larry ^l   Bandera, Elisa V ^m   Becker, Lewis C ^g   Berndt, Sonja I ⁿ   Bernstein, Leslie ^o   Blot, William J ^p,q,r   Boerwinkle, Eric ^s   Britton, Angela ⁱ   Casey, Graham ^b   Chanock, Stephen J ⁿ   Demerath, Ellen ^t   Deming, Sandra L ^q,r   Diver, W Ryan ^u   Fox, Caroline ^v   Harris, Tamara B ⁱ   Hernandez, Dena G ⁱ   Hu, Jennifer J ^w   Ingles, Sue A ^b   John, Esther M ^x,y   Johnson, Craig ^z   Keating, Brendan ^aa   Kittles, Rick A ^ab   Kolonel, Laurence N ^ac   Kritchevsky, Stephen B ^h   Marchand, Loic ^ac   Lohman, Kurt ^h   Liu, Jiankang ^ad   Millikan, Robert C ^ae   Murphy, Adam ^af   Musani, Solomon ^v   Neslund Dudas, Christine ^ag   North, Kari E ^ae,ah   Nyante, Sarah ^ae   Ogunniyi, Adesola ^ai   Ostrander, Elaine A ^j   Papanicolaou, George ^aj   Patel, Sanjay ^ak   Pettaway, Curtis A ^al   Press, Michael F ^b   Redline, Susan ^ak   Rodriguez Gil, Jorge L ^w   Rotimi, Charles ^j   Rybicki, Benjamin A ^ag   Salako, Babatunde ^ai   Schreiner, Pamela J ^am   Signorello, Lisa B ^p,q,r   Singleton, Andrew B ⁱ   Stanford, Janet L ^an   Stram, Alex H ^b   Stram, Daniel O ^b   Strom, Sara S ^al   Suktitipat, Bhoom ^g,ao   Thun, Michael J ^u   Witte, John S ^ap   Yanek, Lisa R ^g   Ziegler, Regina G ⁿ   Zheng, Wei ^q,r   Zhu, Xiaofeng ^aq   Zmuda, Joseph M ^ar   Zonderman, Alan B ⁱ   Evans, Michele K ⁱ   Liu, Yongmei ^h   Becker, Diane M ^g   Cooper, Richard S ^f   Pastinen, Tomi ^e   Henderson, Brian E ^b   Hirschhorn, Joel N ^c,d,as   Lettre, Guillaume ^a,at   Haiman, Christopher A ^b   more..

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e MCGILL UNIVERSITY   (Canada)

^f LOYOLA UNIVERSITY CHICAGO   (United States)

^g JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h WAKE FOREST SCHOOL OF MEDICINE   (United States)

ⁱ NATIONAL INSTITUTE ON AGING   (United States)

^j NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^k ROSWELL PARK CANCER INSTITUTE   (United States)

^l BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

ⁿ NATIONAL CANCER INSTITUTE   (United States)

^o CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^p INTERNATIONAL EPIDEMIOLOGY INSTITUTE   (United States)

^q VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^r VANDERBILT INGRAM CANCER CENTER   (United States)

^s UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^t UNIVERSITY OF MINNESOTA   (United States)

^u AMERICAN CANCER SOCIETY   (United States)

^v UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^w UNIVERSITY OF MIAMI   (United States)

^x CANCER PREVENTION INSTITUTE OF CALIFORNIA   (United States)

^y STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^z UNIVERSITY OF WASHINGTON   (United States)

^aa CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^ab UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^ac UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^ad UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^ae IL   (United States)

^af NORTHWESTERN UNIVERSITY   (United States)

^ag HENRY FORD HOSPITAL   (United States)

^ah UNIVERSITY OF NORTH CAROLINA   (United States)

^ai UNIVERSITY OF IBADAN   (Nigeria)

^aj NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^ak BRIGHAM AND WOMEN S HOSPITAL   (United States)

^al UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^am UNIVERSITY OF MINNESOTA   (United States)

^an Fred Hutchinson Cancer Research Center   (United States)

^ao JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^ap UNIVERSITY OF CALIFORNIA   (United States)

^aq CASE WESTERN RESERVE UNIVERSITY   (United States)

^ar UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^as HARVARD MEDICAL SCHOOL   (United States)

^at UNIVERSITÉ DE MONTRÉAL   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BODY HEIGHT; ETHNIC GROUP; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; SINGLE NUCLEOTIDE POLYMORPHISM; ADULT; AFRICAN AMERICAN; AGED; CAUCASIAN; CHROMOSOME MAP; FEMALE; GENE FREQUENCY; GENETICS; GENOTYPE; MALE; META ANALYSIS; MIDDLE AGED; PHENOTYPE;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; BODY HEIGHT; CHROMOSOME MAPPING; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 80055080761     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002298     Document Type: Article

References (22)

1. Perola M, Sammalisto S, Hiekkalinna T, Martin NG, Visscher PM, et al. (2007) Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet 3: e97 doi:10.1371/journal.pgen.0030097.
2. Visscher PM, Medland SE, Ferreira MA, Morley KI, Zhu G, et al. (2006) Assumption-Free Estimation of Heritability from Genome-Wide Identity-by-Descent Sharing between Full Siblings. PLoS Genet 2: e41 doi:10.1371/journal.pgen.0020041.
3. Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, et al. (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467: 832-838.
4. Fisher RA, (1918) The Correlation Between Relatives on the Supposition of Mendelian Inheritance. Transactions of the Royal Society of Edinburgh 52: 399-433.
5. Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, et al. (2009) A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 41: 527-534.
6. Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, et al. (2010) A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Hum Mol Genet 19: 2303-2312.
7. Kim JJ, Lee HI, Park T, Kim K, Lee JE, et al. (2010) Identification of 15 loci influencing height in a Korean population. J Hum Genet 55: 27-31.
8. Kang SJ, Chiang CW, Palmer CD, Tayo BO, Lettre G, et al. (2010) Genome-wide association of anthropometric traits in African- and African-derived populations. Hum Mol Genet 19: 2725-2738.
9. Shriner D, Adeyemo A, Gerry NP, Herbert A, Chen G, et al. (2009) Transferability and fine-mapping of genome-wide associated loci for adult height across human populations. PLoS ONE 4: e8398 doi:10.1371/journal.pone.0008398.
10. Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet 88: 6-18.
11. Yang J, Weedon MN, Purcell S, Lettre G, Estrada K, et al. (2011) Genomic inflation factors under polygenic inheritance. Eur J Hum Genet.
12. Casarin A, Rusalen F, Doimo M, Trevisson E, Carraro S, et al. (2009) X-linked brachytelephalangic chondrodysplasia punctata: a simple trait that is not so simple. Am J Med Genet A 149A: 2464-2468.
13. Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, et al. (2007) A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet 39: 1245-1250.
14. Sanna S, Jackson AU, Nagaraja R, Willer CJ, Chen WM, et al. (2008) Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet 40: 198-203.
15. Price AL, Patterson N, Yu F, Cox DR, Waliszewska A, et al. (2007) A genomewide admixture map for Latino populations. Am J Hum Genet 80: 1024-1036.
16. Altshuler DM, Gibbs RA, Peltonen L, Dermitzakis E, Schaffner SF, et al. (2010) Integrating common and rare genetic variation in diverse human populations. Nature 467: 52-58.
17. Neptune ER, Frischmeyer PA, Arking DE, Myers L, Bunton TE, et al. (2003) Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet 33: 407-411.
18. Voight BF, Kudaravalli S, Wen X, Pritchard JK, (2006) A map of recent positive selection in the human genome. PLoS Biol 4: e72 doi:10.1371/journal.pbio.0040072.
19. Price AL, Tandon A, Patterson N, Barnes KC, Rafaels N, et al. (2009) Sensitive detection of chromosomal segments of distinct ancestry in admixed populations. PLoS Genet 5: e1000519 doi:10.1371/journal.pgen.1000519.
20. Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, et al. (2011) Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project. PLoS Genet 7: e1001300 doi:10.1371/journal.pgen.1001300.
21. Ge B, Pokholok DK, Kwan T, Grundberg E, Morcos L, et al. (2009) Global patterns of cis variation in human cells revealed by high-density allelic expression analysis. Nat Genet 41: 1216-1222.
22. Pruim RJ, Welch RP, Sanna S, Teslovich TM, Chines PS, et al. (2010) LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26: 2336-2337.