Hypoglycaemic and hypolipidemic activity of Tinospora cordifolia root extract on aflatoxin B1-induced toxicity in mice

International Journal of Research in Pharmaceutical Sciences

Volumn 2, Issue 4, 2011, Pages 585-589

  Sharma, Veena ^a   Gupta, Rekha ^a   Sharma, Shatruhan ^b  

^a BANASTHALI UNIVERSITY   (India)

^b Department of Bioscience and Biotechnology ^*  (India)

Author keywords

Atherosclerosis; Glucose; Lipid profile; Mycotoxins; Protection

Indexed keywords

AFLATOXIN B1; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; TINOSPORA CORDIFOLIA EXTRACT; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GLUCOSE BLOOD LEVEL; HYPERLIPIDEMIA; HYPOGLYCEMIA; IN VIVO STUDY; KIDNEY MASS; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PLANT ROOT; TINOSPORA CORDIFOLIA; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 80055068245     PISSN: None     EISSN: 09757538     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Abdel-Fattah, Sh.M., Sanad, M.I., Safaa, M.A. and Ragaa, F.F.Ghanem. The protective effect of white ginseng biochemical and pathological changes induced by aflatoxins in rats. Journal of American Science, Vol.6, no.12, 2010 pp.461-472.
2. Abdel-Wahhab, M.A., Ahmed, H.H. and Hagazi, M.M. Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts. J. Appl. Toxicol., Vol. 26, no.3, 2006 pp.229-238.
3. Anonymous. Monographs on the evaluation of carcinogenic risk to human some naturally occurring substances. In: Food Items and constituents heterocyclic aromatic amines and mycotoxins.No.56.IARC, Lyon, France, 1993 pp.245-395.
4. Chintawar, G., Jain, A., Sipahimlani, A., Banerjii, A., Sumariwalla, P., Ramakrishanan, R. and Sainis, K. An immunologically active arbinogalacton from Tinospora cordifolia. Phytochem., Vol.52, 1999 pp.1089-1093.
5. Denli, M., Okan, F., Doran, F. and Inal, T.C. Effect of dietary conjugated linoleic acid (CLA) on carcass quality, serum lipid variables and histopathological changes of broiler chickens infected with aflatoxin B1. South African Journal of Animal Sciences, Vol. 35, 2005 pp.109-116.
6. Edrington, T.S., Sarr, A.B., Kubena, L.F., Harvey, R.B. and Phillips, T.D. Hydrated sodium calcium aluminosillicate (HSCAS), acidic HSCAS, and activated charcoal reduce urinary excretion of aflatoxin M1 in turkey poults. Lack of effect by activated charcoal on aflatoxicosis. Toxicol. Lett., Vol. 89, 1996 pp.115-122.
7. Feingold, K.R., Wiley, M.H., Mac, R.G., Moser, A.H., Lear, S.R. and Saperstein, M.D. The effect of diabetes mellitus on sterol synthesis in the diabetic rat. Diabetes, Vol. 31, 1982 pp.388-395.
8. Henry, J.D. Clinical diagnosis and management by laboratory methods, 17th edn, Philadelphia PA, WB saunders, 1984 pp.1433
9. Kaplan, M.M. Laboratory tests. In Diseases of liver; Schiff L., Schiff,E.R., Eds; Lippincott: Philadelphia, PA,1987 pp.219-237.
10. Maurya, R., Dhar, K.I. and Handa, S.S. A sesquiterpene glucoside from Tinospora cordifolia. Phytochem., Vol. 44, no.4, 1997 pp.749-750.
11. Maurya, R., Handa, S.S. Tinocordifolin a sesquiterpene from Tinospora cordifolia. Phytochem., Vol.49, no.5, 1998 pp.1343-1345.
12. Price P.S.M. and Mennon, V.P. Hypoglycaemic and other related action of Tinospora cordifolia roots in alloxan induced diabetic rats. J. Ethenopharma., Vol. 70, 2000 pp.70:9-15.
13. Prince, P.S.M. and Mennon, V.P. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J. Ethenopharma., Vol.65, 1999 pp. 277-281.
14. Ramos, A.J. and Hernandez, E. Prevention of aflatoxicosis in farm animals by means of hydrated sodium calcium aluminosillicate addition to feedstuff:A review. Anim. Feed Sci.Technol., Vol. 65, 1997 pp.197-206.
15. Rastogi, R., Srivastava, A.K. and Rastogi, A.K. Biochemical changes induced in liver and serum of aflatoxin B1 treated male wistar rats: preventive effects of picroliv. Pharmacol. Toxicol., Vol. 88, 2001 pp. 53-58.
16. Santurio, J.M., Mallman, C.A., Rosa, A.P., Appel, G., Heer, A., Dageforde, S. and Bpttcher, M. Effect of sodium bentonite on the performance and blood variables of broiler chickens intoxicated with aflatoxin. Br. Poult. Sci., Vol. 40, 1999, pp.115-119.
17. Schaefer, E.J., Robert I.L. Pathogenesis and management of lipoproteins disorders. The New England J. Med., Vol. 312, 1985 pp.1300-1310.
18. Sharma, V. and Pandey, D. Beneficial Effects of Tinospora cordifolia on Blood Profile in Male Mice Exposed to Lead. Toxicol. Int., Vol.17, no. 1, 2010 pp.8-11.
19. Wogan, G.N. Aflatoxins as risk factors for hepatocellular carcinoma in humans. Cancer Res Suppl., Vol.52, 1992 pp. 2114-2119.
20. Yokozawa, T., Ishida, A., Cho, E.J. and Nakagawa, T. The effect of coptidis rhizome extract on hypercholesterolemic animal model. Phytomed., Vol. 10, 2003 pp.17-22.