In vivo antidiarrheal activity of the ethanolic leaf extract of catharanthus roseus linn. (Apocyanaceae) in wistar rats

African Journal of Pharmacy and Pharmacology

Volumn 5, Issue 15, 2011, Pages 1797-1800

  Hassan, Kyakulaga A ^a   Brenda, Alinda T ^a   Patrick, Vudriko ^a   Patrick, Ogwang E ^b  

^a MAKERERE UNIVERSITY   (Uganda)

^b Division of Pharmacology   (Uganda)

Author keywords

Antidiarrheal; Catharansu roseus; Ethanolic; Phytochemical

Indexed keywords

ALCOHOL; ALKALOID; ATROPINE; CATHARANTHUS ROSEUS EXTRACT; CHARCOAL; FLAVONOID; LOPERAMIDE; SAPONIN; TANNIN; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIARRHEAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG DETERMINATION; DRUG DOSE COMPARISON; IN VIVO STUDY; INTESTINE MOTILITY; INTESTINE TRANSIT TIME; MALE; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; RAT; TREATMENT DURATION;

EID: 80055068233     PISSN: None     EISSN: 19960816     Source Type: Journal    
DOI: 10.5897/AJPP11.505     Document Type: Article

References (9)

1. Abdulkarim A, Sadiq Y, Gabriel OA, Abdulkadir UZ, Ezzeldin MA (2005). Evaluation of five medicinal plants used in diarrhea treatment in Nigeria. J. Ethno. Pharmacol., 101: 27-30.
2. Adeyemi O, Okpo S, Adesanya A (2003). Gastrointestinal activity of the aqueous extract of a Nigerian herbal preparation. West Afr. J. Pharmacol., 19: 22-27.
3. Appidi JR, Grierson DS, Afolayan (2008). Ethno botanical study of plants used for the treatment of diarrhea in the Eastern Cape, South Africa. Pakistan J. Bio. Sci., 11 (15): 1961-1963.
4. Boominathan R, Devi BP, Dewanjee S, Mandal SC (2005). Studies on antidiarrheal activity of Ionodium suffruticosam ging. (Violaceae) extract in rats. Phytotherapeutics. 10: 375-380.
5. Dahiru D, Sini JM, John Africa L (2006). Antidiarrheal activity of Ziziphus mauritiana root extracts in rodents. Afr. J. Biotechnol., 5 (10): 941-945.
6. El-Sayed M, Choi YH, Frédérich M, Roytrakul S, Verpoorte R (2004). Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine. Biotechnol. Lett., 26: 793-798
7. Kong JM, Goh NK, Chia LS, Chia TF (2003). Recent Advances in traditional plant drugs and orchids. Acta Pharmacol. Sin., 24:7-21.
8. Nayak BS, Lexley MPP (2006). Catharanthus roseus flower has wound healing activity in Sprague Dawley rats. BMC Compl. Altern. Med., 6:41.
9. Palombo EA (2006). Phytochemicals from traditional medicinal plants used in treatment of diarrhea: Modes of action and effects on intestinal function. Phytother. Res., 20: 717-724.