Glycan analysis of glycoprotein pharmaceuticals: Evaluation of analytical approaches to Z number determination in pharmaceutical erythropoietin products

Biologicals

Volumn 39, Issue 6, 2011, Pages 396-403

  Yuen, Chun Ting ^a   Zhou, Yong ^b   Wang, Qing Zhou ^b   Hou, Ji Feng ^b   Bristow, Adrian ^a   Wang, Jun Zhi ^b  

^a NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^b NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

Author keywords

EPO; Glycotherapeutics; N glycans analysis; Recombinant erythropoietin; Z number

Indexed keywords

GLYCAN; GLYCOPROTEIN; N ACETYL BETA GLUCOSAMINIDASE; RECOMBINANT ERYTHROPOIETIN;

AMPEROMETRY; ANIMAL CELL; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CHINESE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG RELEASE; DRUG SYNTHESIS; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATHEMATICAL ANALYSIS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; VALIDATION PROCESS;

4-AMINOBENZOIC ACID; ANIMALS; BIOLOGICAL ASSAY; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; ERYTHROPOIETIN; GLYCOPROTEINS; HUMANS; MICE; PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL) ASPARAGINE AMIDASE; PHARMACEUTICAL PREPARATIONS; POLYSACCHARIDES; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 80055062461     PISSN: 10451056     EISSN: 10958320     Source Type: Journal    
DOI: 10.1016/j.biologicals.2011.08.012     Document Type: Article

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