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Volumn 8, Issue 11, 2011, Pages 1798-1803

Successes and failures in modeling heart cell electrophysiology

Author keywords

Biomarker for cardiac arrhythmia; Calcium channel; Cardiac drug toxicity; Cardiac electrophysiology; Computational physiology; Heart cell model; Potassium channel; Sodium channel; Systems biology

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM CHANNEL; G PROTEIN COUPLED RECEPTOR; POTASSIUM CHANNEL HERG; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CHANNEL;

EID: 80055024938     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2011.06.014     Document Type: Article
Times cited : (32)

References (63)
  • 1
    • 35649001607 scopus 로고
    • A quantitative description of membrane current and its application to conduction and excitation in nerve
    • A.L. Hodgkin, and A.F. Huxley A quantitative description of membrane current and its application to conduction and excitation in nerve J Physiol 117 1952 500 544
    • (1952) J Physiol , vol.117 , pp. 500-544
    • Hodgkin, A.L.1    Huxley, A.F.2
  • 4
    • 0000450921 scopus 로고
    • Thresholds and plateaus in the Hodgkin-Huxley nerve equations
    • R. FitzHugh Thresholds and plateaus in the Hodgkin-Huxley nerve equations J Gen Physiol 43 1960 867 896
    • (1960) J Gen Physiol , vol.43 , pp. 867-896
    • Fitzhugh, R.1
  • 5
    • 0018349527 scopus 로고
    • The steady state TTX-sensitive ('window') sodium current in cardiac purkinje fibres
    • DOI 10.1007/BF00586939
    • D. Attwell, I. Cohen, D. Eisner, M. Ohba, and C. Ojeda The steady state TTX sensitive ("window") sodium current in cardiac Purkinje fibres Pflgers Archiv Eur J Physiol 379 1979 137 142 (Pubitemid 9220338)
    • (1979) Pflugers Archiv European Journal of Physiology , vol.379 , Issue.2 , pp. 137-142
    • Attwell, D.1    Cohen, I.2    Eisner, D.3
  • 6
    • 76949111722 scopus 로고
    • Effect of current flow on the membrane potential of cardiac muscle
    • S. Weidmann Effect of current flow on the membrane potential of cardiac muscle J Physiol 115 1951 227 236
    • (1951) J Physiol , vol.115 , pp. 227-236
    • Weidmann, S.1
  • 8
    • 0001411376 scopus 로고
    • Chloride ions and the membrane potential of Purkinje fibres
    • E.E. Carmeliet Chloride ions and the membrane potential of Purkinje fibres J Physiol 156 1961 375 388
    • (1961) J Physiol , vol.156 , pp. 375-388
    • Carmeliet, E.E.1
  • 9
    • 0001013794 scopus 로고
    • Current-voltage relations of Purkinje fibres in sodium-deficient solutions
    • A.E. Hall, O.F. Hutter, and D. Noble Current-voltage relations of Purkinje fibres in sodium-deficient solutions J Physiol 166 1963 225 240
    • (1963) J Physiol , vol.166 , pp. 225-240
    • Hall, A.E.1    Hutter, O.F.2    Noble, D.3
  • 10
    • 36949074283 scopus 로고
    • Rectifying properties of heart muscle
    • O.F. Hutter, and D. Noble Rectifying properties of heart muscle Nature 188 1960 495
    • (1960) Nature , vol.188 , pp. 495
    • Hutter, O.F.1    Noble, D.2
  • 11
    • 36949064203 scopus 로고
    • Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations
    • D. Noble Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations Nature 188 1960 495 497
    • (1960) Nature , vol.188 , pp. 495-497
    • Noble, D.1
  • 12
    • 73849164199 scopus 로고
    • A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pacemaker potentials
    • D. Noble A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pacemaker potentials J Physiol 160 1962 317 352
    • (1962) J Physiol , vol.160 , pp. 317-352
    • Noble, D.1
  • 14
    • 58149175662 scopus 로고    scopus 로고
    • Multiscale modeling of drug-induced effects on cardiac electrophysiological activity
    • T. Brennan, M. Fink, and B. Rodriguez Multiscale modeling of drug-induced effects on cardiac electrophysiological activity Eur J Pharmacol Sci 36 2009 62 77
    • (2009) Eur J Pharmacol Sci , vol.36 , pp. 62-77
    • Brennan, T.1    Fink, M.2    Rodriguez, B.3
  • 15
    • 77953806557 scopus 로고    scopus 로고
    • Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: From experiments to computer simulations
    • A. Corrias, X. Jie, and L. Romero Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations Phil Trans R Soc A 368 2010 3001 3025
    • (2010) Phil Trans R Soc A , vol.368 , pp. 3001-3025
    • Corrias, A.1    Jie, X.2    Romero, L.3
  • 16
    • 67650898593 scopus 로고    scopus 로고
    • Markov models for ion channelsversatility vs. identifiability and speed
    • M. Fink, and D. Noble Markov models for ion channelsversatility vs. identifiability and speed Phil Trans R Soc A 367 2009 2161 2179
    • (2009) Phil Trans R Soc A , vol.367 , pp. 2161-2179
    • Fink, M.1    Noble, D.2
  • 17
    • 77149178709 scopus 로고    scopus 로고
    • Pharmacodynamic effects in the cardiovascular system: The modeler's view
    • M. Fink, and D. Noble Pharmacodynamic effects in the cardiovascular system: the modeler's view Basic Clin Pharmacol Toxicol 106 2010 243 249
    • (2010) Basic Clin Pharmacol Toxicol , vol.106 , pp. 243-249
    • Fink, M.1    Noble, D.2
  • 18
    • 67149130077 scopus 로고    scopus 로고
    • Cellular Open Resource (COR): Current status and future directions
    • A. Garny, D. Noble, P.J. Hunter, and P. Kohl Cellular Open Resource (COR): current status and future directions Phil Trans R Soc A 367 2009 1885 1905
    • (2009) Phil Trans R Soc A , vol.367 , pp. 1885-1905
    • Garny, A.1    Noble, D.2    Hunter, P.J.3    Kohl, P.4
  • 19
    • 79955419099 scopus 로고    scopus 로고
    • Simulation of multiple ion channel block provides improved early prediction of compound's clinical torsadogenic risk
    • G.R. Mirams, Y. Cui, and A. Sher Simulation of multiple ion channel block provides improved early prediction of compound's clinical torsadogenic risk Cardiovasc Res 91 2011 53 61
    • (2011) Cardiovasc Res , vol.91 , pp. 53-61
    • Mirams, G.R.1    Cui, Y.2    Sher, A.3
  • 20
    • 64749109727 scopus 로고    scopus 로고
    • A meta analysis of cardiac electrophysiology computational models
    • S.A. Niederer, M. Fink, D. Noble, and N.P. Smith A meta analysis of cardiac electrophysiology computational models Exp Physiol 94 2009 486 495
    • (2009) Exp Physiol , vol.94 , pp. 486-495
    • Niederer, S.A.1    Fink, M.2    Noble, D.3    Smith, N.P.4
  • 21
    • 46449087223 scopus 로고    scopus 로고
    • Computational models of the heart and their use in assessing the actions of drugs
    • DOI 10.1254/jphs.CR0070042
    • D. Noble Computational Models of the heart and their use in assessing the actions of drugs J Pharmacol Sci 107 2008 107 117 (Pubitemid 351931011)
    • (2008) Journal of Pharmacological Sciences , vol.107 , Issue.2 , pp. 107-117
    • Noble, D.1
  • 22
    • 77951815745 scopus 로고    scopus 로고
    • Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk
    • E. Pueyo, Z. Husti, and T. Hornyik Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk Am J Physiol Heart Circ Physiol 298 2010 H1577 H1587
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Pueyo, E.1    Husti, Z.2    Hornyik, T.3
  • 23
    • 77953811461 scopus 로고    scopus 로고
    • The systems biology approach to drug development: Application to toxicity assessment of cardiac drugs
    • B. Rodriguez, K. Burrage, D. Gavaghan, V. Grau, P. Kohl, and D. Noble The systems biology approach to drug development: application to toxicity assessment of cardiac drugs Clin Pharmacol Ther 88 2010 130 134
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 130-134
    • Rodriguez, B.1    Burrage, K.2    Gavaghan, D.3    Grau, V.4    Kohl, P.5    Noble, D.6
  • 25
    • 0344881257 scopus 로고
    • Ionic currents in cardiac excitation
    • K.A. Deck, and W. Trautwein Ionic currents in cardiac excitation Pflgers Archiv 280 1964 65 80
    • (1964) Pflgers Archiv , vol.280 , pp. 65-80
    • Deck, K.A.1    Trautwein, W.2
  • 26
    • 0014127686 scopus 로고
    • The dependence of slow inward current in Purkinje fibres on the extracellular calcium concentration
    • H. Reuter The dependence of slow inward current in Purkinje fibres on the extracellular calcium concentration J Physiol 192 1967 479 492
    • (1967) J Physiol , vol.192 , pp. 479-492
    • Reuter, H.1
  • 27
    • 0014438985 scopus 로고
    • Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres
    • D. Noble, and R.W. Tsien Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres J Physiol 200 1969 205 231
    • (1969) J Physiol , vol.200 , pp. 205-231
    • Noble, D.1    Tsien, R.W.2
  • 28
    • 0025351245 scopus 로고
    • + current. Differential sensitivity to block by class III antiarrhythmic agent
    • DOI 10.1085/jgp.96.1.195
    • + current Differential sensitivity to block by class III antiarrhythmic agents J Gen Physiol 96 1990 195 215 (Pubitemid 20227082)
    • (1990) Journal of General Physiology , vol.96 , Issue.1 , pp. 195-215
    • Sanguinetti, M.C.1    Jurkiewicz, N.K.2
  • 29
    • 0014266238 scopus 로고
    • The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres
    • D. Noble, and R.W. Tsien The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres J Physiol 195 1968 185 214
    • (1968) J Physiol , vol.195 , pp. 185-214
    • Noble, D.1    Tsien, R.W.2
  • 30
    • 0016826011 scopus 로고
    • Reconstruction of the electrical activity of cardiac Purkinje fibres
    • R.E. McAllister, D. Noble, and R.W. Tsien Reconstruction of the electrical activity of cardiac Purkinje fibres J Physiol 251 1975 1 59
    • (1975) J Physiol , vol.251 , pp. 1-59
    • McAllister, R.E.1    Noble, D.2    Tsien, R.W.3
  • 31
    • 0019393641 scopus 로고    scopus 로고
    • K2, in Purkinje fibres
    • K2, in Purkinje fibres. J Physiol 1081;314:359376.
    • J Physiol , vol.1081 , Issue.314 , pp. 359-376
    • Difrancesco, D.1
  • 33
    • 0012029288 scopus 로고
    • K2 for the modelling of the electrical activity of pacemaker tissues in the heart
    • L.N. Bouman, H.J. Jongsma, Martinus Nijhoff The Hague, Boston, London
    • K2 for the modelling of the electrical activity of pacemaker tissues in the heart L.N. Bouman, H.J. Jongsma, Cardiac Rate and Rhythm 1982 Martinus Nijhoff The Hague, Boston, London 93 128
    • (1982) Cardiac Rate and Rhythm , pp. 93-128
    • Difrancesco, D.1    Noble, D.2
  • 34
    • 0021284516 scopus 로고
    • The surprising heart: A review of recent progress in cardiac electrophysiology
    • D. Noble The surprising heart: a review of recent progress in cardiac electrophysiology J Physiol 353 1984 1 50 (Pubitemid 14061511)
    • (1984) Journal of Physiology , vol.VOL. 353 , pp. 1-50
    • Noble, D.1
  • 35
    • 0017370379 scopus 로고
    • Reconstruction of the action potential of ventricular myocardial fibres
    • Beeler, and H. Reuter Reconstruction of the action potential of ventricular myocardial fibres J Physiol 268 1977 177 210 (Pubitemid 8115094)
    • (1977) Journal of Physiology , vol.268 , Issue.1 , pp. 177-210
    • Beeler, G.W.1    Reuter, H.2
  • 38
    • 0022422465 scopus 로고
    • A model of cardiac electrical activity incorporating ionic pumps and concentration changes
    • D. DiFrancesco, and D. Noble A model of cardiac electrical activity incorporating ionic pumps and concentration changes Phil Trans R Soc B 307 1985 353 398
    • (1985) Phil Trans R Soc B , vol.307 , pp. 353-398
    • Difrancesco, D.1    Noble, D.2
  • 39
    • 0022588238 scopus 로고
    • Na-Ca exchange current in mammalian heart cells
    • J. Kimura, A. Noma, and H. Irisawa Na-Ca exchange current in mammalian heart cells Nature 319 1986 596 597 (Pubitemid 16110949)
    • (1986) Nature , vol.319 , Issue.6054 , pp. 596-597
    • Kimura, J.1    Noma, A.2    Irisawa, H.3
  • 42
    • 0028242153 scopus 로고
    • Dynamics of abnormal pacemaking activity in cardiac Purkinje fibers
    • DOI 10.1006/jtbi.1994.1121
    • A. Varghese, and R.L. Winslow Dynamics of abnormal pacemaking activity in cardiac Purkinje fibres J Theor Biol 168 1994 407 420 (Pubitemid 24215459)
    • (1994) Journal of Theoretical Biology , vol.168 , Issue.4 , pp. 407-420
    • Varghese, A.1    Winslow, R.L.2
  • 43
    • 38248999969 scopus 로고
    • Dynamics of the calcium subsystem in cardiac Purkinje fibres
    • A. Varghese, and R.L. Winslow Dynamics of the calcium subsystem in cardiac Purkinje fibres Physica D 68 1993 364 386
    • (1993) Physica D , vol.68 , pp. 364-386
    • Varghese, A.1    Winslow, R.L.2
  • 44
    • 0033583266 scopus 로고    scopus 로고
    • Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: Model studies
    • R.L. Winslow, J. Rice, and S. Jafri Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II model studies Circ Res 84 1999 571 586 (Pubitemid 29138594)
    • (1999) Circulation Research , vol.84 , Issue.5 , pp. 571-586
    • Winslow, R.L.1    Rice, J.2    Jafri, S.3    Marban, E.4    O'Rourke, B.5
  • 45
    • 0017031594 scopus 로고
    • Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres
    • W.J. Lederer, and R.W. Tsien Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres J Physiol 263 1976 73 100 (Pubitemid 8014941)
    • (1976) Journal of Physiology , vol.263 , Issue.2 , pp. 73-100
    • Lederer, W.J.1    Tsien, R.W.2
  • 46
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart - From genes to cells to the whole organ
    • DOI 10.1126/science.1069881
    • D. Noble Modelling the heart: from genes to cells to the whole organ Science 295 2002 1678 1682 (Pubitemid 34202896)
    • (2002) Science , vol.295 , Issue.5560 , pp. 1678-1682
    • Noble, D.1
  • 47
    • 0023662820 scopus 로고
    • Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: Reconstruction of basic cellular mechanisms
    • D.W. Hilgemann, and D. Noble Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms Proc R Soc Lond B 230 1987 163 205
    • (1987) Proc R Soc Lond B , vol.230 , pp. 163-205
    • Hilgemann, D.W.1    Noble, D.2
  • 48
    • 0025891531 scopus 로고
    • A model of the ventricular cardiac action potential depolarization, repolarisation and their interaction
    • C.-H. Luo, and Y. Rudy A model of the ventricular cardiac action potential depolarization, repolarisation and their interaction Circ Res 68 1991 1501 1526
    • (1991) Circ Res , vol.68 , pp. 1501-1526
    • Luo, C.-H.1    Rudy, Y.2
  • 49
    • 0028233422 scopus 로고
    • A Dynamic model of the cardiac ventricular action potentialsimulations of ionic currents and concentration changes
    • C. Luo, and Y. Rudy A Dynamic model of the cardiac ventricular action potentialsimulations of ionic currents and concentration changes Circ Res 74 1994 1071 1097
    • (1994) Circ Res , vol.74 , pp. 1071-1097
    • Luo, C.1    Rudy, Y.2
  • 50
    • 0028365308 scopus 로고
    • A dynamic model of the cardiac ventricular action potential: II. Afterdepolarizations, triggered activity, and potentiation
    • C. Luo, and Y. Rudy A dynamic model of the cardiac ventricular action potential: II. Afterdepolarizations, triggered activity and potentiation Circ Res 74 1994 1097 1113 (Pubitemid 24176904)
    • (1994) Circulation Research , vol.74 , Issue.6 , pp. 1097-1113
    • Luo, C.-H.1    Rudy, Y.2
  • 51
    • 0022527248 scopus 로고
    • Extracellular calcium transients and action potential configuration changes related to post-stimulatory potentiation in rabbit atrium
    • D.W. Hilgemann Extracellular calcium transients and action potential configuration changes related to post-stimulatory potentiation in rabbit atrium J Gen Physiol 87 1986 675 706 (Pubitemid 16071642)
    • (1986) Journal of General Physiology , vol.87 , Issue.5 , pp. 675-706
    • Hilgemann, D.W.1
  • 52
    • 0021357404 scopus 로고
    • The effects of ryanodine, EGTA and low-sodium on action potentials in rat and guinea-pig ventricular myocytes: Evidence for two inward currents during the plateau
    • M.R. Mitchell, T. Powell, D.A. Terrar, and V.A. Twist The effects of ryanodine, EGTA and low-sodium on action potentials in rat and guinea-pig ventricular myocytes: evidence for two inward currents during the plateau Br J Pharmacol 81 1984 543 550 (Pubitemid 14144401)
    • (1984) British Journal of Pharmacology , vol.81 , Issue.3 , pp. 543-550
    • Mitchell, M.R.1    Powell, T.2    Terrar, D.A.3    Twist, V.W.4
  • 53
    • 17944398302 scopus 로고
    • Calcium induced release of calcium from the sarcoplasmic reticulum
    • A. Fabiato Calcium induced release of calcium from the sarcoplasmic reticulum Am J Physiol 245 1983 C1 C14
    • (1983) Am J Physiol , vol.245
    • Fabiato, A.1
  • 54
    • 0031594597 scopus 로고    scopus 로고
    • 2+ dynamics: The roles of ryanodine receptor adaptation and sarcoplasmic reticulum load
    • 2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load Biophys J 74 1998 1149 1168 (Pubitemid 28108528)
    • (1998) Biophysical Journal , vol.74 , Issue.3 , pp. 1149-1168
    • Jafri, M.S.1    Rice, J.J.2    Winslow, R.L.3
  • 55
    • 0031917543 scopus 로고    scopus 로고
    • Improved guinea-pig ventricular cell model incorporating a diadic space, iKr & iKs, and length- & tension-dependent processes
    • D. Noble, A. Varghese, P. Kohl, and P.J. Noble Improved guinea-pig ventricular cell model incorporating a diadic space, iKr & iKs, and length- & tension-dependent processes Can J Cardiol 14 1998 123 134
    • (1998) Can J Cardiol , vol.14 , pp. 123-134
    • Noble, D.1    Varghese, A.2    Kohl, P.3    Noble, P.J.4
  • 56
    • 0028064828 scopus 로고
    • + concentration at different moments during the action potential in guinea-pig myocytes
    • J.Y. LeGuennec, and D. Noble The effects of rapid perturbation of external sodium concentration at different moments of the action potential in guinea-pig ventricular myocytes J Physiol 478 1994 493 504 (Pubitemid 24243218)
    • (1994) Journal of Physiology , vol.478 , Issue.3 , pp. 493-504
    • Le Guennec, J.-Y.1    Noble, D.2
  • 58
    • 77449141025 scopus 로고    scopus 로고
    • Biophysics and systems biology
    • D. Noble Biophysics and systems biology Phil Trans R Soc A 368 2010 1125 1139
    • (2010) Phil Trans R Soc A , vol.368 , pp. 1125-1139
    • Noble, D.1
  • 59
    • 79951982591 scopus 로고    scopus 로고
    • Differential and integral views of genetics in computational systems biology
    • D. Noble Differential and integral views of genetics in computational systems biology J R Soc Interface Focus 1 2011 7 15
    • (2011) J R Soc Interface Focus , vol.1 , pp. 7-15
    • Noble, D.1
  • 60
    • 79951989259 scopus 로고    scopus 로고
    • Neo-Darwinism, the modern synthesis, and selfish genes: Are they of use in physiology?
    • D. Noble Neo-Darwinism, the modern synthesis, and selfish genes: are they of use in physiology? J Physiol 589 2011 1007 1015
    • (2011) J Physiol , vol.589 , pp. 1007-1015
    • Noble, D.1
  • 62
    • 64749110869 scopus 로고    scopus 로고
    • The cardiac physiome: Perspectives for the future
    • J.B. Bassingthwaighte, P.J. Hunter, and D. Noble The cardiac physiome: perspectives for the future Exp Physiol 94 2009 597 605
    • (2009) Exp Physiol , vol.94 , pp. 597-605
    • Bassingthwaighte, J.B.1    Hunter, P.J.2    Noble, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.