Structure-activity relationships of neuritogenic gentiside derivatives

ChemMedChem

Volumn 6, Issue 11, 2011, Pages 1986-1989

  Luo, Yan ^a   Sun, Kaiyue ^a   Li, Lin ^b   Gao, Lijuan ^a   Wang, Guangfa ^a   Qu, Yuan ^a   Xiang, Lan ^c   Chen, Ling ^b   Hu, Yongzhou ^a   Qi, Jianhua ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

ABG 001; Biological activity; Gentiside derivatives; PC12 cells; Structure activity relationships

Indexed keywords

BENZOIC ACID DERIVATIVE; GENTISIDE D; GENTISIDE E; GENTISIDE F; GENTISIDE K; NERVE GROWTH FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENTIANA; GENTISATES; HYDROXYBENZOIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MAP KINASE SIGNALING SYSTEM; MOLECULAR STRUCTURE; NERVE GROWTH FACTOR; NEURITES; PC12 CELLS; PHOSPHORYLATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80055023363     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100348     Document Type: Article

References (20)

1. R. Levi-Montalcini, Science 1987, 237, 1154-1162.
2. L. F. Kromer, Science 1987, 235, 214-216.
3. R. D. Brinton, R. S. Yamazaki, Pharm. Res. 1998, 15, 386-398.
4. L. A. Greene, A. S. Tischler, Proc. Natl. Acad. Sci. USA 1976, 73, 2424-2428.
5. J. H. Qi, M. Ojika, Y. Sakagami, Tetrahedron 2000, 56, 5835-5841.
6. J. H. Qi, M. Ojika, Y. Sakagami, Bioorg. Med. Chem. 2002, 10, 1961-1966.
7. J. H. Qi, C. G. Han, Y. Sasayama, H. Nakahara, T. Shibata, K. Uchida, M. Ojika, ChemMedChem 2006, 1, 1351-1354.
8. L. J. Gao, J. Y. Li, J. H. Qi, Bioorg. Med. Chem. 2010, 18, 2131-2134.
9. L. J. Gao, L. Xiang, Y. Luo, G. F. Wang, J. Y. Li, J. H. Qi, Bioorg. Med. Chem. 2010, 18, 6995-7000.
10. I. Kubo, K. Fujita, K. Nihei, N. Masuoka, Bioorg. Med. Chem. 2003, 11, 573-580.
11. K. Nihei, A. Nihei, I. Kubo, Bioorg. Med. Chem. Lett. 2003, 13, 3993-3996.
12. Y. Z. Hu, D. L. J. Clive, J. Chem. Soc., Perkin Trans. 1 1997, 1421-1424.
13. T. A. Keating, C. G. Marshall, C. T. Walsh, Biochemistry 2000, 39, 15513-15521.
14. U. Azzena, T. Denurra, E. Fenude, G. Melloni, G. Rassu, Synthesis 1989, 28-30.
15. O. Mitsunobu, Synthesis 1981, 1-28.
16. M. V. Chao, B. L. Hempstead, Trends Neurosci. 1995, 18, 321-326.
17. S. Cowley, H. Paterson, P. Kemp, C. J. Marshall, Cell 1994, 77, 841-852.
18. D. Vaudry, P. J. S. Stork, P. Lazarovici, L. E. Eiden, Science 2002, 296, 1648-1649.
19. M. M. Berg, D. W. Sternberg, L. F. Parada, M. V. Chao, J. Biol. Chem. 1992, 267, 13-16.
20. M. F. Favata, K. Y. Horiuchi, E. J. Manos, A. J. Daulerio, D. A. Stradley, W. S. Feeser, D. E. VanDyk, W. J. Pitts, R. A. Earl, F. Hobbs, R. A. Copeland, R. L. Magolda, P. A. Scherle, J. M. Trzaskos, J. Biol. Chem. 1998, 273, 18623-18632.