De novo infection of B cells during murine gammaherpesvirus 68 latency

Journal of Virology

Volumn 85, Issue 20, 2011, Pages 10920-10925

  Freeman, Michael L ^a   Burkum, Claire E ^a   Yager, Eric J ^b   Woodland, David L ^a   Blackman, Marcia A ^a  

^a TRUDEAU INSTITUTE   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; B LYMPHOCYTE; CONTROLLED STUDY; GAMMAHERPESVIRINAE; HERPES VIRUS INFECTION; IMMUNOCOMPETENCE; IN VIVO STUDY; MOUSE; MURINE GAMMAHERPESVIRUS 68; NONHUMAN; NOTE; PRIORITY JOURNAL; T CELL DEPLETION; VIRUS CELL INTERACTION; VIRUS LATENCY; VIRUS LOAD; VIRUS REACTIVATION; VIRUS TRANSMISSION;

ANIMALS; ANTIBODIES, VIRAL; B-LYMPHOCYTES; LYMPHOCYTE DEPLETION; MICE; MICE, CONGENIC; RHADINOVIRUS; T-LYMPHOCYTES; VIRAL LOAD; VIRUS ACTIVATION; VIRUS INTERNALIZATION; VIRUS LATENCY;

ANIMALIA; MURINAE; MUS;

EID: 80055006744     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05027-11     Document Type: Note

References (26)

1. Cardin, R. D., J. W. Brooks, S. R. Sarawar, and P. C. Doherty. 1996. Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells. J. Exp. Med. 184:863-871.
2. Casper, C., et al. 2007. Frequent and asymptomatic oropharyngeal shedding of human herpesvirus 8 among immunocompetent men. J. Infect. Dis. 195: 30-36.
3. Chang, Y., et al. 1999. Requirement for cell-to-cell contact in Epstein-Barr virus infection of nasopharyngeal carcinoma cells and keratinocytes. J. Virol. 73:8857-8866.
4. Flaño, E., I. J. Kim, D. L. Woodland, and M. A. Blackman. 2002. Gammaherpesvirus latency is preferentially maintained in splenic germinal center and memory B cells. J. Exp. Med. 196:1363-1372.
5. Gargano, L. M., J. C. Forrest, and S. H. Speck. 2009. Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo. J. Virol. 83:1474-1482.
6. Grundhoff, A., and D. Ganem. 2004. Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. J. Clin. Invest. 113:124-136.
7. Ho, M., et al. 1988. The frequency of Epstein-Barr virus infection and associated lymphoproliferative syndrome after transplantation and its manifestations in children. Transplantation 45:719-727.
8. Hong, M., et al. 2006. Suppression of Epstein-Barr nuclear antigen 1 (EBNA1) by RNA interference inhibits proliferation of EBV-positive Burkitt's lymphoma cells. J. Cancer Res. Clin. Oncol. 132:1-8.
9. Hoshino, Y., et al. 2009. Long-term administration of valacyclovir reduces the number of Epstein-Barr virus (EBV)-infected B cells but not the number of EBV DNA copies per B cell in healthy volunteers. J. Virol. 83:11857-11861.
10. Imai, S., J. Nishikawa, and K. Takada. 1998. Cell-to-cell contact as an efficient mode of Epstein-Barr virus infection of diverse human epithelial cells. J. Virol. 72:4371-4378.
11. Kemball, C. C., et al. 2005. Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection. J. Immunol. 174:7950-7960.
12. Kim, I. J., E. Flano, D. L. Woodland, and M. A. Blackman. 2002. Antibodymediated control of persistent gamma-herpesvirus infection. J. Immunol. 168:3958-3964.
13. Martin, D. F., et al. 1999. Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study Group. N. Engl. J. Med. 340:1063-1070.
14. Moser, J. M., J. W. Upton, K. S. Gray, and S. H. Speck. 2005. Ex vivo stimulation of B cells latently infected with gammaherpesvirus 68 triggers reactivation from latency. J. Virol. 79:5227-5231.
15. Niller, H. H., H. Wolf, and J. Minarovits. 2008. Regulation and dysregulation of Epstein-Barr virus latency: implications for the development of autoimmune diseases. Autoimmunity 41:298-328.
16. Pauk, J., et al. 2000. Mucosal shedding of human herpesvirus 8 in men. N. Engl. J. Med. 343:1369-1377.
17. Perera, R. A., L. P. Samaranayake, and C. S. Tsang. 2010. Shedding dynamics of Epstein-Barr virus: A type 1 carcinogen. Arch. Oral Biol. 55:639-647.
18. Ptaschinski, C., J. Wilmore, N. Fiore, and R. Rochford. 2010. In vivo activation of toll-like receptor-9 induces an age-dependent abortive lytic cycle reactivation of murine gammaherpesvirus-68. Viral Immunol. 23:547-555.
19. Rickinson, A. B., and E. Kieff. 2001. Epstein-Barr virus, p. 2575-2627. In P. M. Howley and D. M. Knipe (ed.), Fields virology. Lippincott Williams and Wilkins, Philadelphia, PA.
20. Siegel, A. M., U. S. Rangaswamy, R. J. Napier, and S. H. Speck. 2010. Blimp-1-dependent plasma cell differentiation is required for efficient maintenance of murine gammaherpesvirus latency and antiviral antibody responses. J. Virol. 84:674-685.
21. Snyder, C. M., et al. 2008. Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells. Immunity 29:650-659.
22. Speck, P., and R. Longnecker. 2000. Infection of breast epithelial cells with Epstein-Barr virus via cell-to-cell contact. J. Natl. Cancer Inst. 92:1849-1851.
23. Usherwood, E. J., K. A. Ward, M. A. Blackman, J. P. Stewart, and D. L. Woodland. 2001. Latent antigen vaccination in a model gammaherpesvirus infection. J. Virol. 75:8283-8288.
24. Vezys, V., et al. 2006. Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. J. Exp. Med. 203:2263-2269.
25. Virgin, H. W., et al. 1997. Complete sequence and genomic analysis of murine gammaherpesvirus 68. J. Virol. 71:5894-5904.
26. Weck, K. E., S. S. Kim, H. W. Virgin, and S. H. Speck. 1999. B cells regulate murine gammaherpesvirus 68 latency. J. Virol. 73:4651-4661.