-
1
-
-
77955635233
-
Cancer statistics 2010
-
Epub ahead of print
-
Jemal, A. et al. (2010) Cancer Statistics, 2010. CA Cancer J. Clin., Epub ahead of print
-
(2010)
CA Cancer J. Clin.
-
-
Jemal, A.1
-
2
-
-
0033526309
-
Natural history of progression after PSA elevation following radical prostatectomy
-
DOI 10.1001/jama.281.17.1591
-
Pound, C.R. et al. (1999) Natural history of progression after PSA elevation following radical prostatectomy. JAMA 281, 1591-1597 (Pubitemid 29211767)
-
(1999)
Journal of the American Medical Association
, vol.281
, Issue.17
, pp. 1591-1597
-
-
Pound, C.R.1
Partin, A.W.2
Eisenberger, M.A.3
Chan, D.W.4
Pearson, J.D.5
Walsh, P.C.6
-
3
-
-
0001561849
-
Inhibition of human mammary and prostatic cancers by adrenalectomy
-
Huggins, C. and Bergenstal, D.M. (1952) Inhibition of human mammary and prostatic cancers by adrenalectomy. Cancer Res. 12, 134-141
-
(1952)
Cancer Res.
, vol.12
, pp. 134-141
-
-
Huggins, C.1
Bergenstal, D.M.2
-
4
-
-
4744347762
-
Mechanisms of androgen-refractory prostate cancer
-
DOI 10.1056/NEJMp048178
-
Debes, J.D. and Tindall, D.J. (2004) Mechanisms of androgen-refractory prostate cancer. N. Engl. J. Med. 351, 1488-1490 (Pubitemid 39315314)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.15
, pp. 1488-1490
-
-
Debes, J.D.1
Tindall, D.J.2
-
5
-
-
4744366279
-
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
-
DOI 10.1056/NEJMoa040720
-
Tannock, I.F. et al. (2004) Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N. Engl. J. Med. 351, 1502-1512 (Pubitemid 39315317)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.15
, pp. 1502-1512
-
-
Tannock, I.F.1
De Wit, R.2
Berry, W.R.3
Horti, J.4
Pluzanska, A.5
Chi, K.N.6
Oudard, S.7
Theodore, C.8
James, N.D.9
Turesson, I.10
Rosenthal, M.A.11
Eisenberger, M.A.12
-
6
-
-
77955066199
-
Sipuleucel-T immunotherapy for castrationresistant prostate cancer
-
Kantoff, P.W. et al. (2010) Sipuleucel-T immunotherapy for castrationresistant prostate cancer. N. Engl. J. Med. 363, 411-422
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 411-422
-
-
Kantoff, P.W.1
-
7
-
-
0029103141
-
Prostate cancer trialists' collaborative group (1995) maximum androgen blockade in advanced prostate cancer: An overview of 22 randomised trials with 3283 deaths in 5710 patients
-
Prostate Cancer Trialists' Collaborative Group (1995) Maximum androgen blockade in advanced prostate cancer: an overview of 22 randomised trials with 3283 deaths in 5710 patients. Lancet 346, 265-269
-
Lancet
, vol.346
, pp. 265-269
-
-
-
8
-
-
0032747375
-
Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: Recommendations from the prostate- specific antigen working group
-
Bubley, G.J. et al. (1999) Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group. J. Clin. Oncol. 17, 3461-3467 (Pubitemid 29517916)
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.11
, pp. 3461-3467
-
-
Bubley, G.J.1
Carducci, M.2
Dahut, W.3
Dawson, N.4
Daliani, D.5
Eisenberger, M.6
Figg, W.D.7
Freidlin, B.8
Halabi, S.9
Hudes, G.10
Hussain, M.11
Kaplan, R.12
Myers, C.13
Oh, W.14
Petrylak, D.P.15
Reed, E.16
Roth, B.17
Sartor, O.18
Scher, H.19
Simons, J.20
Sinibaldi, V.21
Small, E.J.22
Smith, M.R.23
Trump, D.L.24
Vollmer, R.25
Wilding, G.26
more..
-
9
-
-
33749550602
-
Persistent intraprostatic androgen concentrations after medical castration in healthy men
-
DOI 10.1210/jc.2006-0968
-
Page, S.T. et al. (2006) Persistent intraprostatic androgen concentrations after medical castration in healthy men. J. Clin. Endocrinol. Metab. 91, 3850-3856 (Pubitemid 44536854)
-
(2006)
Journal of Clinical Endocrinology and Metabolism
, vol.91
, Issue.10
, pp. 3850-3856
-
-
Page, S.T.1
Lin, D.W.2
Mostaghel, E.A.3
Hess, D.L.4
True, L.D.5
Amory, J.K.6
Nelson, P.S.7
Matsumoto, A.M.8
Bremner, W.J.9
-
10
-
-
34250331066
-
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer
-
DOI 10.1158/0008-5472.CAN-06-3332
-
Mostaghel, E.A. et al. (2007) Intraprostatic androgens and androgenregulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 67, 5033-5041 (Pubitemid 46910214)
-
(2007)
Cancer Research
, vol.67
, Issue.10
, pp. 5033-5041
-
-
Mostaghel, E.A.1
Page, S.T.2
Lin, D.W.3
Fazli, L.4
Coleman, I.M.5
True, L.D.6
Knudsen, B.7
Hess, D.L.8
Nelson, C.C.9
Matsumoto, A.M.10
Bremner, W.J.11
Gleave, M.E.12
Nelson, P.S.13
-
11
-
-
1842612441
-
Molecular determinants of resistance to antiandrogen therapy
-
DOI 10.1038/nm972
-
Chen, C.D. et al. (2004) Molecular determinants of resistance to antiandrogen therapy. Nat. Med. 10, 33-39 (Pubitemid 38524696)
-
(2004)
Nature Medicine
, vol.10
, Issue.1
, pp. 33-39
-
-
Chen, C.D.1
Welsbie, D.S.2
Tran, C.3
Baek, S.H.4
Chen, R.5
Vessella, R.6
Rosenfeld, M.G.7
Sawyers, C.L.8
-
12
-
-
42549140720
-
Targeted therapy of cancer: New roles for pathologists - Prostate cancer
-
DOI 10.1038/modpathol.2008.11, PII MODPATHOL200811
-
Rubin, M.A. (2008) Targeted therapy of cancer: new roles for pathologists - prostate cancer. Mod Pathol. 21 (Suppl. 2), S44-55 (Pubitemid 351592771)
-
(2008)
Modern Pathology
, vol.21
, Issue.SUPPL. 2
-
-
Rubin, M.A.1
-
14
-
-
0036112592
-
The current state of hormonal therapy for prostate cancer
-
Hellerstedt, B.A. and Pienta, K.J. (2002) The current state of hormonal therapy for prostate cancer. CA Cancer J. Clin. 52, 154-179 (Pubitemid 34546107)
-
(2002)
Ca-A Cancer Journal for Clinicians
, vol.52
, Issue.3
, pp. 154-179
-
-
Hellerstedt, B.A.1
Pienta, K.J.2
-
15
-
-
0027249588
-
Response to flutamide withdrawal in advanced prostate cancer in progression under combination therapy
-
Dupont, A. et al. (1993) Response to flutamide withdrawal in advanced prostate cancer in progression under combination therapy. J. Urol. 150, 908-913 (Pubitemid 23241297)
-
(1993)
Journal of Urology
, vol.150
, Issue.3
, pp. 908-913
-
-
Dupont, A.1
Gomez, J.-L.2
Cusan, L.3
Koutsilieris, M.4
Labrie, F.5
-
16
-
-
0027477695
-
Prostate specific antigen decline after antiandrogen withdrawal: The flutamide withdrawal syndrome
-
Kelly, W.K. and Scher, H.I. (1993) Prostate specific antigen decline after antiandrogen withdrawal: the flutamide withdrawal syndrome. J. Urol. 149, 607-609 (Pubitemid 23094069)
-
(1993)
Journal of Urology
, vol.149
, Issue.3
, pp. 607-609
-
-
Kelly, W.K.1
Scher, H.I.2
-
17
-
-
0028256111
-
Prostate-specific antigen decline after casodex withdrawal: Evidence for an antiandrogen withdrawal syndrome
-
DOI 10.1016/0090-4295(94)90092-2
-
Small, E.J. and Carroll, P.R. (1994) Prostate-specific antigen decline after casodex withdrawal: evidence for an antiandrogen withdrawal syndrome. Urology 43, 408-410 (Pubitemid 24111446)
-
(1994)
Urology
, vol.43
, Issue.3
, pp. 408-410
-
-
Small, E.J.1
Carroll, P.R.2
-
18
-
-
0028998340
-
Molecular implications of the antiandrogen withdrawal syndrome
-
Moul, J.W. et al. (1995) Molecular implications of the antiandrogen withdrawal syndrome. Semin. Urol. 13, 157-163
-
(1995)
Semin. Urol.
, vol.13
, pp. 157-163
-
-
Moul, J.W.1
-
19
-
-
34047181147
-
Drug insight: Role of the androgen receptor in the development and progression of prostate cancer
-
Taplin, M.E. (2007) Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat. Clin. Pract. Oncol. 4, 236-244
-
(2007)
Nat. Clin. Pract. Oncol.
, vol.4
, pp. 236-244
-
-
Taplin, M.E.1
-
20
-
-
0025644325
-
A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens
-
Veldscholte, J. et al. (1990) A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens. Biochem. Biophys. Res. Commun. 173, 534-540
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.173
, pp. 534-540
-
-
Veldscholte, J.1
-
21
-
-
0033152164
-
Selection for androgen receptor mutations in prostatecancers treated withandrogenantagonist
-
Taplin, M.E. et al. (1999) Selection for androgen receptor mutations in prostatecancers treated withandrogenantagonist. CancerRes.59, 2511-2515
-
(1999)
CancerRes.
, vol.59
, pp. 2511-2515
-
-
Taplin, M.E.1
-
22
-
-
1842457650
-
Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: A phase III trial (CALGB 9583)
-
DOI 10.1200/JCO.2004.06.037
-
Small, E.J. et al. (2004) Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583). J. Clin. Oncol. 22, 1025-1033 (Pubitemid 41095034)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.6
, pp. 1025-1033
-
-
Small, E.J.1
Halabi, S.2
Dawson, N.A.3
Stadler, W.M.4
Rini, B.I.5
Picus, J.6
Gable, P.7
Torti, F.M.8
Kaplan, E.9
Vogelzang, N.J.10
-
23
-
-
0021167082
-
Ketoconazole therapy for advanced prostate cancer
-
Trachtenberg, J. and Pont, A. (1984) Ketoconazole therapy for advanced prostate cancer. Lancet 2, 433-435 (Pubitemid 14059393)
-
(1984)
Lancet
, vol.2
, Issue.8400
, pp. 433-435
-
-
Trachtenberg, J.1
Pont, A.2
-
24
-
-
0021832898
-
In vitro inhibition of testosterone biosynthesis by ketoconazole
-
Sikka, S.C. et al. (1985) In vitro inhibition of testosterone biosynthesis by ketoconazole. Endocrinology 116, 1920-1925 (Pubitemid 15067769)
-
(1985)
Endocrinology
, vol.116
, Issue.5
, pp. 1920-1925
-
-
Sikka, S.C.1
Swerdloff, R.S.2
Rajfer, J.3
-
25
-
-
56349121553
-
CYP17 inhibition as a hormonal strategy for prostate cancer
-
Reid, A.H. et al. (2008) CYP17 inhibition as a hormonal strategy for prostate cancer. Nat. Clin. Pract. Urol. 5, 610-620
-
(2008)
Nat. Clin. Pract. Urol.
, vol.5
, pp. 610-620
-
-
Reid, A.H.1
-
26
-
-
28544432178
-
Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer
-
DOI 10.1111/j.1464-410X.2005.05821.x
-
Attard, G. et al. (2005) Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU Int. 96, 1241-1246 (Pubitemid 41743917)
-
(2005)
BJU International
, vol.96
, Issue.9
, pp. 1241-1246
-
-
Attard, G.1
Belldegrun, A.S.2
De Bono, J.S.3
-
27
-
-
0028031372
-
Pharmacology of novel steroidal inhibitors of cytochrome p450(17α) (17α-hydroxylase/C17-20 lyase)
-
DOI 10.1016/0960-0760(94)90131-7
-
Barrie, S.E. et al. (1994) Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J. Steroid Biochem. Mol. Biol. 50, 267-273 (Pubitemid 24309119)
-
(1994)
Journal of Steroid Biochemistry and Molecular Biology
, vol.50
, Issue.5-6
, pp. 267-273
-
-
Barrie, S.E.1
Potter, G.A.2
Goddard, P.M.3
Haynes, B.P.4
Dowsett, M.5
Jarman, M.6
-
28
-
-
67449119425
-
Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven
-
Attard, G. et al. (2009) Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven. Cancer Res. 69, 4937-4940
-
(2009)
Cancer Res.
, vol.69
, pp. 4937-4940
-
-
Attard, G.1
-
29
-
-
3042784503
-
17,20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer
-
O'Donnell, A. et al. (2004) Hormonal impact of the 17alpha-hydroxylase/ C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. Br. J. Cancer 90, 2317-2325 (Pubitemid 38961894)
-
(2004)
British Journal of Cancer
, vol.90
, Issue.12
, pp. 2317-2325
-
-
O'Donnell, A.1
Judson, I.2
Dowsett, M.3
Raynaud, F.4
Dearnaley, D.5
Mason, M.6
Harland, S.7
Robbins, A.8
Halbert, G.9
Nutley, B.10
Jarman, M.11
-
30
-
-
77951518711
-
Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate
-
Reid, A.H. et al. (2010) Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate. J. Clin. Oncol. 28, 1489-1495
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1489-1495
-
-
Reid, A.H.1
-
31
-
-
53749090666
-
Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
-
Attard, G. et al. (2008) Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J. Clin. Oncol. 26, 4563-4571
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 4563-4571
-
-
Attard, G.1
-
32
-
-
68949094223
-
Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer
-
Attard, G. et al. (2009) Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer. J. Clin. Oncol. 27, 3742-3748
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 3742-3748
-
-
Attard, G.1
-
33
-
-
77951523950
-
Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy
-
Ryan, C.J. et al. (2010) Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy. J. Clin. Oncol. 28, 1481-1488
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1481-1488
-
-
Ryan, C.J.1
-
34
-
-
77951591066
-
Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castrationresistant prostate cancer
-
Danila, D.C. et al. (2010) Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castrationresistant prostate cancer. J. Clin. Oncol. 28, 1496-1501
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1496-1501
-
-
Danila, D.C.1
-
35
-
-
78649919788
-
Abiraterone acetate (AA) plus low dose prednisone (P) improves overall survival (OS) in patients with metastatic castration resistant prostate cancer (MCRPC) who have progressed after docetaxelbased chemotherapy: Results of COU-AA-301, A Randomized Double-blind Placebo-controlled Phase III Study
-
De Bono, J.S. et al. (2010) Abiraterone acetate (AA) plus low dose prednisone (P) improves overall survival (OS) in patients with metastatic castration resistant prostate cancer (MCRPC) who have progressed after docetaxelbased chemotherapy: results of COU-AA-301, A Randomized Double-blind Placebo-controlled Phase III Study. Ann. Oncol. 21 (Suppl. 8), LBA5
-
(2010)
Ann. Oncol.
, vol.21
, Issue.SUPPL. 8
-
-
De Bono, J.S.1
-
36
-
-
53349101498
-
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3betahydroxy- 17-(1H-benzimidazole- 1-yl)androsta-5,16-diene in prostate cancer
-
Vasaitis, T. et al. (2008) Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3betahydroxy- 17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer. Mol. Cancer Ther. 7, 2348-2357
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 2348-2357
-
-
Vasaitis, T.1
-
37
-
-
20944449560
-
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: Synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model
-
DOI 10.1021/jm040202w
-
Handratta, V.D. et al. (2005) Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. J. Med. Chem. 48, 2972-2984 (Pubitemid 40552912)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.8
, pp. 2972-2984
-
-
Handratta, V.D.1
Vasaitis, T.S.2
Njar, V.C.O.3
Gediya, L.K.4
Kataria, R.5
Chopra, P.6
Newman Jr., D.7
Farquhar, R.8
Guo, Z.9
Qiu, Y.10
Brodie, A.M.H.11
-
38
-
-
78649523986
-
Safety, pharmacokinetics, and efficacy of TAK-700 in metastatic castration-resistant prostrate cancer: A phase I/II, open-label study
-
Abstract
-
Dreicer, R. et al. (2010) Safety, pharmacokinetics, and efficacy of TAK-700 in metastatic castration-resistant prostrate cancer: a phase I/II, open-label study. J. Clin. Oncol. 28 (15-suppl.), Abstract 3084
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.15 SUPPL.
, pp. 3084
-
-
Dreicer, R.1
-
39
-
-
65649090203
-
Development of a second-generation antiandrogen for treatment of advanced prostate cancer
-
Tran, C. et al. (2009) Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324, 787-790
-
(2009)
Science
, vol.324
, pp. 787-790
-
-
Tran, C.1
-
40
-
-
77952105685
-
Antitumour activity of MDV3100 in castrationresistant prostate cancer: A phase 1-2 study
-
Scher, H.I. et al. (2010) Antitumour activity of MDV3100 in castrationresistant prostate cancer: a phase 1-2 study. Lancet 375, 1437-1446.
-
(2010)
Lancet
, vol.375
, pp. 1437-1446
-
-
Scher, H.I.1
|