Substitution of the human αc region with the analogous chicken domain generates a fibrinogen with severely impaired lateral aggregation: Fibrin monomers assemble into protofibrils but protofibrils do not assemble into fibers

Biochemistry

Volumn 50, Issue 42, 2011, Pages 9066-9075

  Ping, Lifang ^a   Huang, Lihong ^a   Cardinali, Barbara ^a   Profumo, Aldo ^b   Gorkun, Oleg V ^a   Lord, Susan T ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORBANCES; HYDRODYNAMIC RADIUS; MIXED POLYMERS; PROTOFIBRILS; THIN FIBERS;

ANIMALS; MONOMERS; POLYMERIZATION; POLYMERS; TURBIDITY;

FIBERS;

COPOLYMER; EDETIC ACID; FIBRIN MONOMER; FIBRINOGEN; FIBRINOPEPTIDE; MONOMER; PLASMIN; THROMBIN;

ARTICLE; CATALYSIS; CHICKEN; FIBER; FIBRIN POLYMERIZATION; HUMAN; HYBRID; HYDRODYNAMICS; LIGHT SCATTERING; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN VARIANT; PROTOFIBRIL; TURBIDITY;

AMINO ACID SUBSTITUTION; ANIMALS; CHICKENS; CHO CELLS; CRICETINAE; CRICETULUS; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; HUMANS; MUTANT CHIMERIC PROTEINS; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 80054991411     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201094v     Document Type: Article

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