Ancrod and fibrin formation: Perspectives on mechanisms of action

Stroke

Volumn 42, Issue 11, 2011, Pages 3277-3280

  Liu, Shuo ^a   Marder, Victor J ^b   Levy, David E ^c   Wang, Shur Jen ^a   Yang, Fan ^a   Paganini Hill, Annlia ^a   Fisher, Mark J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

ancrod; defibrinogenation; fibrinogen; fibrinolysis; ischemic stroke

Indexed keywords

ANCROD; ANTIGEN; FIBRIN; FIBRINOGEN; FIBRINOPEPTIDE A; GLUCOSE; OXYGEN; PLASMINOGEN; TISSUE TYPE PLASMINOGEN ACTIVATOR ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; BRAIN ISCHEMIA; CELL FREE SYSTEM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; ENDOTHELIUM CELL; FIBRIN FORMATION; FIBRINOLYSIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; MICROVASCULAR ENDOTHELIAL CELL; PRIORITY JOURNAL;

ANCROD; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; ENDOTHELIUM, VASCULAR; FIBRIN; HUMANS; STROKE;

EID: 80054990150     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.622753     Document Type: Article

References (14)

1. Hossmann V, Heiss WD, Bewermeyer H, Wiedemann G. Controlled trial of ancrod in ischemic stroke. Arch Neurol. 1983;40:803-808. (Pubitemid 14204323)
2. Sherman DG, Atkinson RP, Chippendale T, Levin KA, Ng K, Futrell N, et al. Intravenous ancrod for treatment of acute ischemic stroke: the STAT study: A randomized controlled trial. Stroke Treatment with Ancrod Trial. JAMA. 2000;283:2395-2403. (Pubitemid 30257538)
3. Hennerici MG, Kay R, Bogousslavsky J, Lenzi GL, Verstraete M, Orgogozo JM. Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: A randomised controlled trial. Lancet. 2006;368:1871-1878. (Pubitemid 44794528)
4. Levy DE, del Zoppo GJ, Demaerschalk BM, Demchuk AM, Diener HC, Howard G, et al. Ancrod in acute ischemic stroke: results of 500 subjects beginning treatment within 6 hours of stroke onset in the ancrod stroke program. Stroke. 2009;40:3796-3803.
5. Dempfle CE, Argiriou S, Alesci S, Kucher K, Muller-Peltzer H, Rubsamen K, et al. Fibrin formation and proteolysis during ancrod treatment. Evidence for des-A-profibrin formation and thrombin independent factor XIII activity. Ann N Y Acad Sci. 2001;936:210-214. (Pubitemid 32613906)
6. Dempfle CE, Argiriou S, Kucher K, Muller-Peltzer H, Rubsamen K, Heene DL. Analysis of fibrin formation and proteolysis during intravenous administration of ancrod. Blood. 2000;96:2793-2802.
7. Lowe GD, Morrice JJ, Forbes CD, Prentice CR, Fulton AJ, Barbenel JC. Subcutaneous ancrod therapy in peripheral arterial disease: improvement in blood viscosity and nutritional blood flow. Angiology. 1979;30: 594-599.
8. Soszka T, Kirschbaum NE, Stewart GJ, Budzynski AZ. Effect of fibrinogen-clotting enzymes on secretion of plasminogen activators from cultured human endothelial cells. Fibrinolysis. 1988;2:49-57. (Pubitemid 18056295)
9. Levy DE, Del Zoppo GJ. Ancrod: A potential treatment for acute, ischemic stroke from snake venom. Toxin Rev. 2006;25:323-333. (Pubitemid 43880064)
10. Clauss A. Rapid physiological coagulation method in determination of fibrinogen. Acta Haematol. 1957;17:237-246.
11. Kim JA, Tran ND, Li Z, Yang F, Zhou W, Fisher MJ. Brain endothelial hemostasis regulation by pericytes. J Cereb Blood Flow Metab. 2006;26: 209-217. (Pubitemid 43151577)
12. Prentice CR, Hampton KK, Grant PJ, Nelson SR, Nieuwenhuizen W, Gaffney PJ. The fibrinolytic response to ancrod therapy: characterization of fibrinogen and fibrin degradation products. Br J Haematol. 1993;83: 276-281. (Pubitemid 23060925)
13. Pizzo SV, Schwartz ML, Hill RL, McKee PA. Mechanism of ancrod anticoagulation. A direct proteolytic effect on fibrin. J Clin Invest. 1972; 51:2841-2850.
14. Okada Y, Copeland B, Fitridge R, Koziol J, del Zoppo G. Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion. Stroke. 1994;25: 1847-1853.