Correlation between lipid deposition, immune-inflammatory cell content and MHC class II expression in diffuse intimal thickening of the human aorta

Atherosclerosis

Volumn 219, Issue 1, 2011, Pages 171-183

  Bobryshev, Yuri V ^a,b   Andreeva, Elena R ^c   Mikhailova, Irina A ^c   Andrianova, Irina V ^a   Moisenovich, Michael M ^d   Khapchaev, Shamil ^d   Agapov, Igor I ^d   Sobenin, Igor A ^a,e   Lusta, Konstantin A ^a   Orekhov, Alexander N ^a,e  

^a Institute of Chemical Problems of Ecology   (Russian Federation)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

^d MOSCOW STATE UNIVERSITY   (Russian Federation)

^e INSTITUTE OF GENERAL PATHOLOGY AND PATHOPHYSIOLOGY   (Russian Federation)

Author keywords

Aorta; Dendritic cells; HLA DR; Immune inflammation; Intima; Lipids

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; HLA DR ANTIGEN; LIPID; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PHOSPHOLIPID; TRIACYLGLYCEROL;

ADULT; ANTIGEN EXPRESSION; AORTA; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BIOACCUMULATION; CELL ACTIVATION; CHROMATOGRAPHY; ELASTIC FIBER; ELECTRON MICROSCOPY; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY CELL; INTIMA; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TISSUE SECTION;

ADULT; AORTA; AZO COMPOUNDS; HLA-DR ALPHA-CHAINS; HUMANS; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; MALE; MIDDLE AGED; TUNICA INTIMA;

EID: 80054989842     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.07.016     Document Type: Article

References (59)

1. Vanderlaan P.A., Reardon C.A. Thematic review series: the immune system and atherogenesis. The unusual suspects: an overview of the minor leukocyte populations in atherosclerosis. J Lipid Res 2005, 46:829-838.
2. Hansson G.K. Atherosclerosis - an immune disease: the Anitschkov Lecture 2007. Atherosclerosis 2009, 202:2-10.
3. Hansson G.K., Hermansson A. The immune system in atherosclerosis. Nat Immunol 2011, 12:204-212.
4. Bobryshev Y.V. Dendritic cells in atherosclerosis: current status of the problem and clinical relevance. Eur Heart J 2005, 26:1700-1704.
5. Wick G., Romen M., Amberger A., et al. Atherosclerosis, autoimmunity, and vascular-associated lymphoid tissue. FASEB J 1997, 11:1199-1207.
6. Wick G., Knoflach M., Xu Q. Autoimmune and inflammatory mechanisms in atherosclerosis. Annu Rev Immunol 2004, 22:361-403.
7. Jores L., Herz, Gefasse Handbuch der speziellen pathologischen Anatomie und Histologie 1924, Springer, Berlin. F. Henke, F. Lubarsch (Eds.).
8. Anichkow N.N. Vessels. Handbook on particular human anatomy and pathology. Part II. Heart and vessels 1947, 262-558. Medgiz, Moscow. A.I. Abrikosov (Ed.).
9. Geer J.C., McGill H.C., Strong J.P., Holman R.L. Electron microscopy of human atherosclerotic lesions. Fed Proc 1960, 19:15-18.
10. Schwartz S.M., deBlois D., O'Brien E.R.M. The intima: soil for atherosclerosis and restenosis. Circ Res 1995, 77:445-465.
11. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999, 340:115-126.
12. Velican D., Velican C. Histochemical study on the glucosaminoglycans (acid mycopolisacharides) of the human coronary arteries. Acta Histochem 1977, 59:190-200.
13. Velican C., Velican D. Heterogeneity in the composition and aggregation patterns of coronary intima acid mucopolysaccharides (glycosaminoglycans). Atherosclerosis 1978, 29:141-159.
14. Orekhov A.N., Karpova I.I., Tertov V.V., et al. Cellular composition of atherosclerotic and uninvolved human aortic subendothelial intima. Light-microscopic study of dissociated aortic cells. Am J Pathol 1984, 115:17-24.
15. Orekhov A.N., Tertov V.V., Novikov I.D., et al. Lipids in cells of atherosclerotic and uninvolved human aorta. I. Lipid composition of aortic tissue and enzyme-isolated and cultured cells. Exp Mol Pathol 1985, 42:117-137.
16. Guyton J.R., Bocan T.M., Schifani T.A. Quantitative ultrastructural analysis of perifibrous lipid and its association with elastin in nonatherosclerotic human aorta. Arteriosclerosis 1985, 5:644-652.
17. Orekhov A.N., Andreeva E.R., Krushinsky A.V., et al. Intimal cells and atherosclerosis. Relationship between the number of intimal cells and major manifestations of atherosclerosis in the human aorta. Am J Pathol 1986, 125:402-415.
18. Orekhov A.N., Andreeva E.R., Tertov V. The distribution of cells and chemical components in the intima of human aorta. Soc Med Rev A: Cardiol 1987, 1:75-100.
19. Mukhin D.N., Orekhov A.N., Andreeva E.R., Schindeler E.M., Smirnov V.N. Lipids in cells of atherosclerotic and uninvolved human aorta. III. Lipid distribution in intimal sublayers. Exp Mol Pathol 1991, 54:22-30.
20. Rekhter M.D., Andreeva E.R., Mironov A.A., Orekhov A.N. Three-dimensional cytoarchitecture of normal and atherosclerotic intima of human aorta. Am J Pathol 1991, 138:569-580.
21. Bobryshev Y.V., Lord R.S. Ultrastructural recognition of cells with dendritic cell morphology in human aortic intima. Contacting interactions of vascular dendritic cells in athero-resistant and athero-prone areas of the normal aorta. Arch Histol Cytol 1995, 58:307-322.
22. Bobryshev Y.V., Lord R.S. Langhans cells of human arterial intima: uniform by stellate appearance but different by nature. Tissue Cell 1996, 28:177-194.
23. Andreeva E.R., Pugach I.M., Gordon D., Orekhov A.N. Continuous subendothelial network formed by pericyte-like cells in human vascular bed. Tissue Cell 1998, 30:127-135.
24. Velican C., Velican D., Tancu I. The relationship between intimal necrosis and lipid accumulation during the onset and progression of atherosclerotic lesions. Med Interne 1988, 26:97-107.
25. Stary H.C. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Atherosclerosis 1989, 9:119-132.
26. Andreeva E.R., Orekhov A.N., Smirnov V.N. Quantitative estimation of lipid-laden cells in atherosclerotic lesions of the human aorta. Acta Anat (Basel) 1991, 141:316-323.
27. Andreeva E.R., Pugach I.M., Orekhov A.N. Collagen-synthesizing cells in initial and advanced atherosclerotic lesions of human aorta. Atherosclerosis 1997, 130:133-142.
28. Orekhov A.N., Andreeva E.R., Andrianova I.V., Bobryshev Y.V. Peculiarities of cell composition and cell proliferation in different type atherosclerotic lesions in carotid and coronary arteries. Atherosclerosis 2010, 212:436-443.
29. Willens S.L. The nature of diffuse intimal thickening of arteries. Am J Pathol 1951, 27:825-833.
30. Movat H.Z., More R.H., Haust M.D. The diffuse intimal thickening of the human aorta with aging. Am J Pathol 1958, 34:1023-1031.
31. Stary H.C., Chandler A.B., Glagov S., et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1994, 89:2462-2478.
32. Bobryshev Y.V., Lord R.S., Warren B.A. Calcified deposit formation in intimal thickenings of the human aorta. Atherosclerosis 1995, 118:9-21.
33. Virmani R., Kolodgie F.D., Burke A.P., Farb A., Schwartz S.M. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000, 20:1262-1275.
34. Poston R.N., Hussain I.F. The immunohistochemical heterogeneity of atheroma macrophages: comparison with lymphoid tissues suggests that recently blood-derived macrophages can be distinguished from longer-resident cells. J Histochem Cytochem 1993, 41:1503-1512.
35. Galkina E., Ley K. Leukocyte influx in atherosclerosis. Curr Drug Targets 2007, 8:1239-1248.
36. Weber C., Zernecke A., Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol 2008, 8:802-815.
37. Bobryshev Y.V., Lord R.S. Expression of heat shock protein-70 by dendritic cells in the arterial intima and its potential significance in atherogenesis. J Vasc Surg 2002, 35:368-375.
38. Pearse A.G.E. Histochemistry: theoretical and applied 1969, Churchill Ltd., London.
39. Bobryshev Y.V., Lord R.S. Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions. Cardiovasc Res 1998, 37:799-810.
40. Bobryshev Y.V., Cherian S.M., Inder S.J., Lord R.S. Neovascular expression of VE-cadherin in human atherosclerotic arteries and its relation to intimal inflammation. Cardiovasc Res 1999, 43:1003-1017.
41. Bobryshev Y.V., Moisenovich M.M., Pustovalova O.L., Agapov I.I., Orekhov A.N. Widespread distribution of HLA-DR-expressing cells in macroscopically undiseased intima of the human aorta: a possible role in surveillance and maintenance of vascular homeostasis. Immunobiology 2011, [April 22; Epub ahead of print].
42. Guyton J.R., Klemp K.F. Ultrastructural discrimination of lipid droplets and vesicles in atherosclerosis: value of osmium-thiocarbohydrazide-osmium and tannic acid-paraphenylenediamine techniques. J Histochem Cytochem 1988, 36:1319-1328.
43. Bobryshev Y.V., Lord R.S. Accumulation of co-localized unesterified cholesterol and neutral lipids within vacuolised elastin fibres in athero-prone areas of the human aorta. Atherosclerosis 1999, 142:121-131.
44. Kruth H.S. Localization of unesterified cholesterol in human atherosclerotic lesions. Demonstration of filipin-positive, Oil-Red-O-negative particles. Am J Pathol 1984, 114:201-208.
45. Sobenin I.A., Maksumova M.A., Slavina E.S., Balabolkin M.I., Orekhov A.N. Sulfonylureas induce cholesterol accumulation in cultured human intimal cells and macrophages. Atherosclerosis 1994, 105:159-163.
46. Tertov V.V., Orekhov A.N. Metabolism of native and naturally occurring multiple modified low density lipoprotein in smooth muscle cells of human aortic intima. Exp Mol Pathol 1997, 64:127-145.
47. Tertov V.V., Sobenin I.A., Kaplun V.V., Orekhov A.N. Antioxidant content in low density lipoprotein and lipoprotein oxidation in vivo and in vitro. Free Radic Res 1998, 29:165-173.
48. Thorne S.A., Abbot S.E., Stevens C.R., et al. Modified low density lipoprotein and cytokines mediate monocyte adhesion to smooth muscle cells. Atherosclerosis 1996, 127:167-176.
49. Handunnetthi L., Ramagopalan S.V., Ebers G.C., Knight J.C. Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. Genes Immun 2010, 11:99-112.
50. Bobryshev Y.V., Watanabe T. Ultrastructural evidence for association of vascular dendritic cells with T-lymphocytes and with B-cells in human atherosclerosis. J Submicrosc Cytol Pathol 1997, 29:209-221.
51. Berliner J.A., Watson A.D. A role for oxidized phospholipids in atherosclerosis. N Engl J Med 2005, 353:9-11.
52. Babaev V.R., Bobryshev Y.V., Sukhova G.K., Kasantseva I.A. Monocyte/macrophage accumulation and smooth muscle cell phenotypes in early atherosclerotic lesions of human aorta. Atherosclerosis 1993, 100:237-248.
53. Montecucco F., Mach F. Update on statin-mediated anti-inflammatory activities in atherosclerosis. Semin Immunopathol 2009, 31:127-142.
54. Klingenberg R., Hansson G.K. Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies. Eur Heart J 2009, 30:2838-2844.
55. Bentzon J.F., Falk E. Atherosclerotic lesions in mouse and man: is it the same disease?. Curr Opin Lipidol 2010, 21:434-440.
56. Brooke B.S., Bayes-Genis A., Li D.Y. New insights into elastin and vascular disease. Trends Cardiovasc Med 2003, 13:176-181.
57. Katsuda S., Kaji T. Atherosclerosis and extracellular matrix. J Atheroscler Thromb 2003, 10:267-274.
58. Noma A., Takahashi T., Wada T. Elastin-lipid interaction in the arterial wall. Part 2. In vitro binding of lipoprotein-lipids to arterial elastin and the inhibitory effect of high density lipoproteins on the process. Atherosclerosis 1981, 38:373-382.
59. Seyama Y., Wachi H. Atherosclerosis and matrix dystrophy. J Atheroscler Thromb 2004, 11:236-245.