Light activation of a cysteine protease inhibitor: Caging of a peptidomimetic nitrile with Ru II(bpy) 2

Journal of the American Chemical Society

Volumn 133, Issue 43, 2011, Pages 17164-17167

  Respondek, Tomasz ^a   Garner, Robert N ^d   Herroon, MacKenzie K ^b   Podgorski, Izabela ^b,c   Turro, Claudia ^d   Kodanko, Jeremy J ^a,c  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEASE; CYSTEINE PROTEASE INHIBITORS; ENZYME INHIBITORS; HUMAN CELLS; ISOLATED ENZYMES; LIGHT ACTIVATION; MASS SPECTROMETRIC DATA; NOVEL METHODS; PEPTIDOMIMETICS; PHOTO-INDUCED; PROTEASE INHIBITOR; VISIBLE LIGHT;

AMINO ACIDS; CYANIDES; FUNCTIONAL GROUPS;

ENZYME INHIBITION;

CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; FUNCTIONAL GROUP; NITRILE; PAPAIN; RUTHENIUM;

AQUEOUS SOLUTION; ARTICLE; CELL LYSATE; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; LIGHT; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; ULTRAVIOLET RADIATION;

2,2'-DIPYRIDYL; CYSTEINE PROTEASES; CYSTEINE PROTEINASE INHIBITORS; LIGHT; MODELS, MOLECULAR; NITRILES; ORGANOMETALLIC COMPOUNDS; PEPTIDOMIMETICS; RUTHENIUM;

EID: 80054986776     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja208084s     Document Type: Article

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