The effects of Lyprinol ® on delayed onset muscle soreness and muscle damage in well trained athletes: A double-blind randomised controlled trial

Complementary Therapies in Medicine

Volumn 19, Issue 6, 2011, Pages 311-318

  Pumpa, Kate L ^a   Fallon, Kieran E ^b   Bensoussan, Alan ^c   Papalia, Shona ^d  

^a UNIVERSITY OF CANBERRA   (Australia)

^b AUSTRALIAN INSTITUTE OF SPORT   (Australia)

^c WESTERN SYDNEY UNIVERSITY   (Australia)

^d UNIVERSITY OF WESTERN SYDNEY   (Australia)

Author keywords

Acute phase response; DOMS; Exercise; Lyprinol ; Muscle damage; Recovery

Indexed keywords

C REACTIVE PROTEIN; CREATINE KINASE; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; LYPRINOL; MYOGLOBIN; TUMOR NECROSIS FACTOR ALPHA;

ABSENCE OF SIDE EFFECTS; ADULT; ALGOMETER; ARTICLE; ATHLETE; BLOOD ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DELAYED ONSET MUSCLE SORENESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE INJURY; MYOSITIS; PAIN ASSESSMENT; PROTEIN BLOOD LEVEL; QUADRICEPS FEMORIS MUSCLE; RANDOMIZED CONTROLLED TRIAL; TREADMILL EXERCISE; TREATMENT DURATION; TREATMENT RESPONSE; VISUAL ANALOG SCALE;

ADOLESCENT; ADULT; ANIMALS; ATHLETIC PERFORMANCE; BIVALVIA; CREATINE KINASE; DOUBLE-BLIND METHOD; HUMANS; INFLAMMATION MEDIATORS; LIPIDS; MALE; MOVEMENT; MUSCLE, SKELETAL; MUSCULOSKELETAL DISEASES; MUSCULOSKELETAL PAIN; MYOGLOBIN; OXYGEN CONSUMPTION; PAIN MEASUREMENT; RUNNING; TREATMENT OUTCOME; YOUNG ADULT;

EID: 80054986769     PISSN: 09652299     EISSN: 18736963     Source Type: Journal    
DOI: 10.1016/j.ctim.2011.08.004     Document Type: Article

References (46)

1. Byrne C., Eston R. The effect of exercise-induced muscle damage on isometric and dynamic knee extensor strength and vertical jump performance. J Sports Sci 2002, 20(5):417-425.
2. MacIntyre D.L., Reid W.D., McKenzie D.C. Delayed muscle soreness. The inflammatory response to muscle injury and its clinical implications. Sports Med 1995, 20(1):24-40.
3. Cleary M.A., Kimura I.F., Sitler M.R., Kendrick Z.V. Temporal pattern of the repeated bout effect of eccentric exercise on delayed-onset muscle soreness. J Athl Train 2002, 37(1):32-36.
4. Armstrong R.B. Mechanisms of exercise-induced delayed onset muscular soreness: a brief review. Med Sci Sports Exerc 1984, 16(6):529-538.
5. Gulick D.T.K., Iris F., Sitler M., Paolone A., Kelly I.V., John D. Various treatment techniques on SIgns and symptoms of delayed onset muscle soreness. J Athl Train 1996, 31(2):145-152.
6. Cheung K.H., Patria A., Maxwell Linda Delayed onset muscle soreness: treatment strategies and performance factors. Sports Med 2003, 33(2):145-164.
7. Smith L.L. Acute inflammation: the underlying mechanism in delayed onset muscle soreness?. Med Sci Sports Exerc 1991, 23(5):542-551.
8. Dudley G.A., Czerkawski J., Meinrod A., Gillis G., Baldwin A., Scarpone M. Efficacy of naproxen sodium for exercise-induced dysfunction muscle injury and soreness. Clin J Sport Med 1997, 7(1):3-10.
9. Phillips T., Childs A.C., Dreon D.M., Phinney S., Leeuwenburgh C. A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Med Sci Sports Exerc 2003, 35(12):2032-2037.
10. Malm C., Sjödin B., Sjöberg B., Lenkei R., Renström P., Lundberg I.E., et al. Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running. J Physiol 2004, 556(Pt 3):983-1000.
11. Nosaka K., Newton M., Sacco P. Delayed-onset muscle soreness does not reflect the magnitude of eccentric exercise-induced muscle damage. Scand J Med Sci Sports 2002, 12(6):337-346.
12. Semark A., Noakes T.D., Gibson A.S.C., Lambert M.I. The effect of a prophylactic dose of flurbiprofen on muscle soreness and sprinting performance in trained subjects. J Sports Sci 1999, 17(3):197-203.
13. Zhang J., Clement D., Taunton J. The efficacy of Farabloc, an electromagnetic shield, in attenuating delayed-onset muscle soreness. Clin J Sport Med 2000, 10(1):15-21.
14. Almekinders L.C. Anti-inflammatory treatment of muscular injuries in sport. An update of recent studies. Sports Med 1999, 28(6):383-388.
15. Connolly D.A., Sayers S.P., McHugh M.P. Treatment and prevention of delayed onset muscle soreness. J Strength Cond Res 2003, 17(1):197-208.
16. Cho SH, Jung YB, Seong SC, Park HB, Byun KY, Lee DC, et al., Clinical efficacy and safety of Lyprinol®, a patented extract from new zealand green-lipped mussel (Perna canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial. 2003.
17. Sinclair A.J., Murphy K.J., Li D. Marine lipids: overview "news insights and lipid composition of Lyprinol" Allerg Immunol (Paris) 2000, 32(7):261-271.
18. Halpern G.M. Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol). Allerg Immunol (Paris) 2000, 32(7):272-278.
19. Gibson R.G., Gibson S.L., Conway V., Chappell D. Perna canaliculus in the treatment of arthritis. Practitioner 1980, 224(1347):955-960.
20. Gibson S.G R.G. The treatment of arthritis with lipid extract of Perna canaliculus: a randomized trial. Complement Ther Med 1998, 6:122-126.
21. Bierer T.L., Bui L.M. Improvement of arthritic signs in dogs fed green-lipped mussel (Perna canaliculus). J Nutr 2002, 132(6 Suppl. 2):1634S-1636S.
22. Bui L., Bierer T. Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs. Vet Ther 2003, 4(4):397-407.
23. Whitehouse MWR, MS, Brooks PM, Over the Counter (OTC) oral remedies for arthritis and rheumatism: how effective are they? 1999.
24. Emelyanov A., Fedoseev G., Krasnoschekova O., Abulimity A., Trendeleva T., Barnes P.J. Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial. Eur Respir J 2002, 20(3):596-600.
25. Eston R.G., Finney S., Baker S., Baltzopoulos V. Muscle tenderness and peak torque changes after downhill running following a prior bout of isokinetic eccentric exercise. J Sports Sci 1996, 14(4):291-299.
26. Eston R.G., Lemmey A.B., McHugh P., Byrne C., Walsh S.E. Effect of stride length on symptoms of exercise-induced muscle damage during a repeated bout of downhill running. Scand J Med Sci Sports 2000, 10(4):199-204.
27. Ramsbottom R., Brewer J., Williams C. A progressive shuttle run test to estimate maximal oxygen uptake. Br J Sports Med 1988, 22(4):141-144.
28. Braun W.A., Dutto D.J. The effects of a single bout of downhill running and ensuing delayed onset of muscle soreness on running economy performed 48h later. Eur J Appl Physiol 2003, 90(1):29-34.
29. Bobbert M.F., Hollander A.P., Huijing P.A. Factors in delayed onset muscular soreness of man. Med Sci Sports Exerc 1986, 18(1):75-81.
30. Cleak M.J., Eston R.G. Muscle soreness, swelling, stiffness and strength loss after intense eccentric exercise. Br J Sports Med 1992, 26(4):267-272.
31. Gleeson N., Eston R., Marginson V., McHugh M. Effects of prior concentric training on eccentric exercise induced muscle damage. Br J Sports Med 2003, 37(2):119-125. discussion 125.
32. Hasson S.M., Daniels J.C., Divine J.G., Niebuhr B.R., Richmond S., Stein P.G., et al. Effect of ibuprofen use on muscle soreness, damage, and performance: a preliminary investigation. Med Sci Sports Exerc 1993, 25(1):9-17.
33. Baker S.J., Kelly N.M., Eston R.G. Pressure pain tolerance at different sites on the quadriceps femoris prior to and following eccentric exercise. Eur J Pain 1997, 1(3):229-233.
34. Brennum J., Kjeldsen M., Jensen K., Staehelin Jensen T. Measurements of human pressure-pain thresholds on fingers and toes. Pain 1989, 38(2):211-217.
35. Nussbaum E.L., Downes L. Reliability of clinical pressure-pain algometric measurements obtained on consecutive days. Phys Ther 1998, 78(2):160-169.
36. Kubo K., Yata H., Kanehisa H., Fukunaga T. Effects of isometric squat training on the tendon stiffness and jump performance. Eur J Appl Physiol 2006, 96(3):305-314.
37. Byrnes W.C., Clarkson P.M., White J.S., Hsieh S.S., Frykman P.N., Maughan R.J. Delayed onset muscle soreness following repeated bouts of downhill running. J Appl Physiol 1985, 59(3):710-715.
38. Stauber W.T. Eccentric action of muscles: physiology, injury, and adaptation. Exerc Sport Sci Rev 1989, 17:157-185.
39. Clarkson P.M., Byrnes W.C., McCormick K.M., Turcotte L.P., White J.S. Muscle soreness and serum creatine kinase activity following isometric, eccentric, and concentric exercise. Int J Sports Med 1986, 7(3):152-155.
40. Roxin L.E., Hedin G., Venge P. Muscle cell leakage of myoglobin after long-term exercise and relation to the individual performances. Int J Sports Med 1986, 7(5):259-263.
41. Lecomte J.M., Lacroix V.J., Montgomery D.L. A randomized controlled trial of the effect of naproxen on delayed onset muscle soreness and muscle strength. Clin J Sport Med 1998, 8(2):82-87.
42. Tokmakidid S.P.K., Smilios I E.A., Douda H. The effects of Ibuprofen on delayed onset muscle soreness and muscular performance after eccentric exercise. J Strength Cond Res 2003, 17(1):53-59.
43. Fallon K.E. The acute phase response and exercise: the ultramarathon as prototype exercise. Clin J Sport Med 2001, 11(1):38.
44. Kuipers H., Keizer H.A., Verstappen F.T., Costill D.L. Influence of a prostaglandin-inhibiting drug on muscle soreness after eccentric work. Int J Sports Med 1985, 6(6):336-339.
45. Bourgeois J., MacDougall D., MacDonald J.A.Y., Tarnopolsky M. Naproxen does not alter indices of muscle damage in resistance-exercise trained men. Med Sci Sports Exerc 1999, 31(1):4-9.
46. Francis K.T., Hoobler T. Effects of aspirin on delayed muscle soreness. J Sports Med Phys Fitness 1987, 27(3):333-337.