Reversible cardiomyopathy associated with sunitinib and sorafenib

New England Journal of Medicine

Volumn 365, Issue 17, 2011, Pages 1649-1650

  Uraizee, Imran ^a   Cheng, Susan ^a   Moslehi, Javid ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LISINOPRIL; SORAFENIB; SUNITINIB;

ADULT; AGED; CARDIOMYOPATHY; CASE REPORT; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG WITHDRAWAL; DYSPNEA; ECHOCARDIOGRAPHY; FEMALE; GASTROINTESTINAL STROMAL TUMOR; HEART EJECTION FRACTION; HEART LEFT ATRIUM; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HUMAN; HYPOKINESIA; LEG EDEMA; LETTER; LIVER CELL CARCINOMA; MALE; ORTHOPNEA; PAROXYSMAL DYSPNEA; PRIORITY JOURNAL;

EID: 80054958413     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1108849     Document Type: Letter

References (5)

1. Ebos JM, Kerbel RS. Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol 2011;8:210-21. [Errata, Nat Rev Clin Oncol 2011;8:221, 316.]
2. Kerkela R, Woulfe KC, Durand JB, et al. Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci 2009;2:15-25.
3. Chintalgattu V, Ai D, Langley RR, et al. Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest 2010;120: 472-84.
4. May D, Gilon D, Djonov V, et al. Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci U S A 2008;105:282-7.
5. Hare JL, Brown JK, Leano R, Jenkins C, Woodward N, Marwick TH. Use of myocardial deformation imaging to detect preclinical myocardial dysfunction before conventional measures in patients undergoing breast cancer treatment with trastuzumab. Am Heart J 2009;158:294-301.