Postoperative adjuvant chemotherapy in patients with ypN+ after preoperative chemoradiation for rectal cancer: Need for randomized trials

Journal of Surgical Oncology

Volumn 104, Issue 7, 2011, Pages 859-860

  Huh, Jung Wook ^a  

^a Chonnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CAPECITABINE; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ADVANCED CANCER; CANCER ADJUVANT THERAPY; CANCER CONTROL; CANCER SPECIFIC SURVIVAL; CANCER STAGING; CANCER SURVIVAL; CHEMORADIOTHERAPY; DISEASE FREE SURVIVAL; HIGH RISK PATIENT; HUMAN; LETTER; OVERALL SURVIVAL; POSTOPERATIVE ADJUVANT CHEMOTHERAPY; POSTOPERATIVE CARE; PRACTICE GUIDELINE; PREOPERATIVE CARE; PREOPERATIVE CHEMORADIATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECTUM CANCER; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME;

ANTINEOPLASTIC AGENTS; CHEMORADIOTHERAPY; CHEMOTHERAPY, ADJUVANT; HUMANS; NEOADJUVANT THERAPY; NEOPLASM STAGING; POSTOPERATIVE CARE; RECTAL NEOPLASMS; SURVIVAL ANALYSIS;

EID: 80054956882     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21952     Document Type: Letter

References (8)

1. Edge SB, Byrd DR, Compton CC, et al., editors: AJCC cancer staging manual, 7th edition. Chicago, IL: Springer; 2010.
2. Collette L, Bosset JF, den Dulk M, et al.: Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: Does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group. J Clin Oncol 2007; 25: 4379-4386. (Pubitemid 350013843)
3. Huh JW, Kim HR,: Postoperative chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer: Is it essential for patients with ypT0-2N0? J Surg Oncol 2009; 100: 387-391.
4. Das P, Skibber JM, Rodriguez-Bigas MA, et al.: Clinical and pathologic predictors of locoregional recurrence, distant metastasis, and overall survival in patients treated with chemoradiation and mesorectal excision for rectal cancer. Am J Clin Oncol 2006; 29: 219-224. (Pubitemid 44270928)
5. Fietkau R, Barten M, Klautke G, et al.: Postoperative chemotherapy may not be necessary for patients with ypN0-category after neoadjuvant chemoradiotherapy of rectal cancer. Dis Colon Rectum 2006; 49: 1284-1292. (Pubitemid 44401376)
6. Janjan NA, Crane C, Feig BW, et al.: Improved overall survival among responders to preoperative chemoradiation for locally advanced rectal cancer. Am J Clin Oncol 2001; 24: 107-112. (Pubitemid 32323343)
7. Bosset JF, Collette L, Calais G, et al.: Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006; 355: 1114-1123. (Pubitemid 44394918)
8. Sauer R, Becker H, Hohenberger W, et al.: Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004; 351: 1731-1740.