Insulin resistance index (HOMA-IR) levels in a general adult population: Curves percentile by gender and age. The EPIRCE study

Diabetes Research and Clinical Practice

Volumn 94, Issue 1, 2011, Pages 146-155

  Gayoso Diz, Pilar ^a,b   Otero Gonzalez, Alfonso ^c   Rodriguez Alvarez, María Xosé ^a,b   Gude, Francisco ^a,b   Cadarso Suarez, Carmen ^b,d   García, Fernando ^e   De Francisco, Angel ^f  

^a Instituto de Salud Carlos III   (Spain)

^b Santiago University Clinical Hospital   (Spain)

^c Nephrology Department   (Spain)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^e HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^f HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

Author keywords

Gender; Insulin resistance; Lifestyles

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BLOOD SAMPLING; BODY MASS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GENDER; GENERALIZED ADDITIVE MODEL; HUMAN; INSULIN RESISTANCE; INSULIN RESISTANCE INDEX; LIFESTYLE; MALE; METABOLISM; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; PHYSICAL EXAMINATION; SEX DIFFERENCE; SPAIN; STATISTICAL MODEL; STRUCTURED INTERVIEW; WAIST CIRCUMFERENCE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INSULIN RESISTANCE; LIFE STYLE; MALE; MIDDLE AGED; SEX FACTORS; YOUNG ADULT;

EID: 80054953339     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2011.07.015     Document Type: Article

References (48)

1. Bunt J.C., Krakoff J., Ortega E., Knowler W.C., Bogardus C. Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations. Diab Metab Res Rev 2007, 23:304-310.
2. Martin B.C., Warram J.H., Krolewski A.S., Bergman R.N., Soeldner J.S., Kahn C.R. Role of glucose and insulin resistance in development of type 2 diabetes mellitus. Lancet 1992, 340:925-929.
3. Ginsberg H.N. Insulin resistance and cardiovascular disease. J Clin Invest 2000, 106:453-458.
4. Bertoni A.G., Wong N.D., Shea S., Ma S., Liu K., Preethi S., et al. Insulin resistance, metabolic syndrome and subclinical atherosclerosis. Diabetes Care 2007, 30:2951-2956.
5. Li C.L., Tsai S.T., Chou P. Relative role of insulin resistance and beta-cell dysfunction in the progression to type 2 diabetes - the Kinmen Study. Diab Metab Res Rev 2003, 59:225-232.
6. Hanley A.J., Williams K., Stern M.P., Haffner S.M. Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. Diabetes Care 2002, 25:1177-1184.
7. Geloneze B., Repetto E.M., Geloneze S.R., Tambascia M.A., Ermetice M.N. The threshold value for insulin resistance (HOMA-IR) in an admixture population. IR in the Brazilian Metabolic Syndrome Study. Diabetes Res Clin Pract 2006, 72:219-220.
8. Bonora E., Kiechl S., Willeit J., Oberhollenzer F., Egger G., Meigs J.B., et al. Insulin resistance as estimated by Homeostasis Model Assessment predicts incident symptomatic cardiovascular disease in Caucasian subjects from the general population. The Bruneck Study. Diabetes Care 2007, 30:318-324.
9. National Committee for Clinical Laboratory Standards (NCCLS) How to define and determine reference intervals in the clinical laboratory; approved guideline. NCCLS document C-28-A2 2000, NCCLS, Wayne, PA. 2nd ed.
10. Balkau B., Mhamdi L., Oppert J.M., Nolan J., Golay A., Porcellati F., et al. Physical activity and insulin sensitivity. The RISC study. Diabetes 2008, 57:2613-2618.
11. Rimm E.B., Williams P., Fosher K., Criqui M., Stampfer M.J. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ 1999, 319:1523-1528.
12. Lann D., LeRoith D. Insulin resistance as the underlying cause for the metabolic syndrome. Med Clin North Am 2007, 91:1063-1077.
13. Ryder E., Gomez M.E., Fernandez V., Campos G., Morales L.M., Valbuena H., et al. Presence of impaired insulin secretion and insulin resistance in normoglycemic male subjects with family history of type 2 diabetes. Diabetes Res Clin Pract 2003, 60:95-103.
14. Chen J., Wildman R.P., Hamm L.L., Muntner P., Reynolds K., Whelton P.K., et al. Third National Health and Nutrition Examination Survey. Association between inflammation and insulin resistance in U.S. nondiabetic adults: results from the Third National Health and Nutrition Examination Survey. Diabetes Care 2004, 27:2960-2965.
15. Eckel R.H., Kahn R., Robertson R.M., Rizza R.A. Preventing cardiovascular disease and diabetes: a call for action from the American Diabetes Association and the American Heart Association. Circulation 2006, 113:2943-2946.
16. Otero A., Gayoso P., Garcia F., De Francisco A.L. Epidemiology of chronic renal disease in the Galician population: results of the pilot Spanish EPIRCE study. Kidney Int 2005, 99(Suppl.):S16-S19.
17. Otero A., De Francisco A., Gayoso P., Garcia F. Prevalence of chronic renal disease in Spain: results of the EPIRCE Study. Nefrologia 2010, 30:78-86.
18. The expert committee on the diagnosis and classification of diabetes mellitus: report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2002, 25:S5-S20.
19. Gual A., Martos A.R., Lligona A., Llopis J.J. Does the concept of a standard drink apply to viticultural societies?. Alcohol Alcohol 1999, 34:153-160.
20. Chobanian A.V., Bakris G.L., Black H.R. The seventh report of the joint national committee on prevention, detection, evaluation and treatment of high blood pressure. JAMA 2003, 289:2560-2571.
21. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 1985, 28:412-419.
22. Hastie T.J., Tibshirani R.J. Generalized additive models 1990, Chapman and Hall, London.
23. Wood S.N. Generalized additive models: an introduction with R 2006, Chapman and Hall/CRC Press.
24. Rigby R.A., Stasinopoulos D.M. Generalized additive models for location, scale and shape (with discussion). Appl Stat 2005, 54:507-554.
25. R Development Core Team R: a language and environment for statistical computing [article online] 2009, R Foundation for Statistical Computing, Vienna, Austria, Available from http://www.R-project.org [accessed 23.03.2010].
26. Kahn R. The metabolic syndrome (emperor) wears no clothes. Diabetes Care 2006, 29:1693-1696.
27. DeFronzo R.A., Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic vascular disease. Diabetes Care 1991, 14:173-194.
28. Ferrannini E., Vichi S., Beck-Nielsen H., Laakso M., Paolisso G., Smith U. Insulin action and age. Diabetes 1996, 45:947-953.
29. Esteghamati A., Ashraf H., Esteghamati A.R., Meysamie A., Khalilzadeh O., Nakhjavani M., et al. Optimal threshold of homeostasis model assessment for insulina resistance in an Iranian population: the implication of the metabolic syndrome to detect insulin resistance. Diab Res Clin Pract 2009, 84:279-287.
30. Kim S.H., Abbasi F., Reaven G.M. Impact of degree of obesity on surrogate estimates of insulin resistance. Diabetes Care 2004, 27:1998-2002.
31. Ritchie S.A., Connell J.M. The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis 2007, 17:319-326.
32. Moreno B., Casanueva F. Identification, diagnosis and control of patients with abdominal obesity and cardiovascular and metabolic risk factors. Med Clin (Barc) 2007, 128:429-437.
33. Geer E.B., Shen W. Gender differences in insulin resistance, body composition and energy balance. Gend Med 2009, 6:60-75.
34. Do H.D., Lohsoonthorn V., Jiamjarasrangsi W., Lertmaharit S., Williams M.A. Prevalence of insulin resistance and its relationship with cardiovascular disease risk factors among Thai adults over 35 years old. Diabetes Res Clin Pract 2010, 89:303-308.
35. Chung B.-H., Doran S., Liang P., Osterlund L., Cho B.H., Oster R.A., et al. Alcohol mediated enhancement of postprandial lipemia: a contributing factor to an increase in plasma HDL and a decrease in risk of cardiovascular disease. Am J Clin Nutr 2003, 78:391-399.
36. Bonora E., Targher G., Alberiche M., Bonadonna R., Saggiani F., Zenere M., et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 2000, 23:57-63.
37. Esteghamati A., Ashraf H., Khalilzadeh O., Zandieh A., Nakhjavani M., Rashidi A., et al. Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR) for the diagnosis of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007). Nutr Metab 2010, 7:26.
38. Matsumoto J.K., Miyake S., Yano M., Ueki Y., Yamaguchi Y., Akazawa S., et al. Glucose tolerance, insulin secretion and insulin sensitivity in nonobese and obese Japanese subjects. Diabetes Care 1997, 20:1562-1568.
39. Nakai Y., Fukushima M., Nakaishi S., Kishimoto H., Seino Y., Nagasaka S., et al. The threshold value for insulin resistance on homeostasis model assessment of insulin sensitivity. Diabetic Med 2002, 9:344-348.
40. De Luis D.A., Gonzalez Sagrado M., Conde R., Aller R., Izazola O., Perez Castrillon J.L., et al. Relation of resistin levels with cardiovascular risk factors and insulin resistance in non-diabetes obese patients. Diabetes Res Clin Pract 2009, 84(June (3)):174-178.
41. Rojo-Martinez G., Esteva I., Ruiz de Adana S., Catala M., Merelo M.J., Tinahones F. Patterns of insulin resistance in the general population of southeast Spain. Diab Res Clin Pract 2004, 65:247-256.
42. Ascaso J.F., Romero P., Real J.T., Priego A., Valdecabres C., Carmena R. Insulin resistance quantification by fasting insulin plasma values and HOMA index in a non-diabetic population. Med Clin (Barc) 2001, 117(November (14)):530-533.
43. Tomé M.A., Botana M.A., Cadarso-Suarez C., Rego-Irateta A., Fernandez-Mariño A., Mato J.A., et al. Prevalence of metabolic syndrome in Galicia (NW Spain) on four alternative definitions and association with insulina resistance. J Endocrinol Invest 2009, 32:505-511.
44. Hedblad B., Nilsson P., Jnazon L., Berglund G. Relation between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects. Results from a cross-sectional study in Malmo, Sweden. Diabetic Med 2000, 17:299-307.
45. Bonora E., Kiechl S., Willeit J., Oberhollenzer F., Egger G., Targher G., et al. Prevalence of insulin resistance in metabolic disorders. The Bruneck Study. Diabetes 1998, 47:1643-1649.
46. Marques-Vidal P., Mazoyer E., Bongard V., Gourdy P., Ruidavets J.B., Drouet L., et al. Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers. Diabetes Care 2002, 25(August (8)):1371-1377.
47. Sumner A.E., Cowie C.C. Ethnic differences in the ability of triglyceride levels to identify insulin resistance. Atherosclerosis 2008, 196:696-703.
48. Hayes L., Pearce M.S., Firbank M.J., Walker M., Taylor R., Unwin N.C. Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study. BMC Public Health 2010, 10:723.