SPECT imaging of dopamine transporters with 99mTc-TRODAT-1 in major depression and Parkinson's disease

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 23, Issue 1, 2011, Pages 63-67

  Wu, Hao ^a   Lou, Cen ^a   Huang, Zhongke ^a   Shi, Guohua ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

[2 [[2 [[[3 (4 CHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCT 2 YL]METHYL](2 MERCAPTOETHYL)AMINO]ETHYL]AMINO]ETHANETHIOLATO]OXOTECHNETIUM TC 99M; DOPAMINE TRANSPORTER;

ADULT; AGED; ARTICLE; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR DEPRESSION; MALE; NEUROIMAGING; NIGRONEOSTRIATAL SYSTEM; PARKINSON DISEASE; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ADULT; AGED; CORPUS STRIATUM; DEPRESSIVE DISORDER, MAJOR; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; HUMANS; MALE; MIDDLE AGED; ORGANOTECHNETIUM COMPOUNDS; PARKINSON DISEASE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TROPANES;

EID: 80054937288     PISSN: 08950172     EISSN: 15457222     Source Type: Journal    
DOI: 10.1176/appi.neuropsych.23.1.63     Document Type: Article

References (21)

1. Stein DJ, Daniels WM, Savitz J, et al: Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology. CNS Spectr 2008; 13:945-949
2. Schrijvers D, Hulstijn W, Sabbe BG: Psychomotor symptoms in depression: a diagnostic, pathophysiological and therapeutic tool. J Affect Disord 2008; 109:1-20
3. Varrone A, Sansone V, Pellecchia MT, et al: Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT. Eur J Nucl Med Mol Imaging 2008; 35:1343-139
4. Zubal IG, Early M, Yuan O, et al: Optimized, automated striatal uptake analysis applied to SPECT brain scans of Parkinson's disease patients. J Nucl Med 2007; 48:857-864
5. Shen YT (ed): Psychiatry, 5th ed. Beijing, The People's Health Publishing, 2009, pp 548-551
6. Chinese Classification of Mental Disorders, 3rd ed (CCMD-3). Shandong Science and Technology Publishing Company, 2001, pp 83-90
7. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed, Text Revision. Washington, DC, American Psychiatric Association, 2000, pp 349-356
8. Zhang JW, Zhu LJ, Du JQ, et al: Dopamine transporter distribution in patients with Parkinson disease of different stages detected using single-photon emission computed tomography brain imaging. Neural Regen Res 2007; 2:18-21
9. Kung HF, Kim HJ, Kung MP, et al: Imaging of dopamine transporters in humans with technetium 99m-TRODAT-1. Eur J Nucl Med 1996; 23:1527-1530
10. Siderowf A, Newberg A, Chou KL, et al: [99mTc]TRODAT-1 SPECT imaging correlates with odor identification in early Parkinson disease. Neurology 2005; 64:1716-1720
11. Tzen KY, Lu CS, Yen TC, et al: Differential diagnosis of Parkinson's disease and vascular parkinsonism by (99m)Tc-TRODAT-1. J Nucl Med 2001; 42:408-413
12. Meyer JH: Applying neuroimaging ligands to study major depressive disorder. Semin Nucl Med 2008; 38:287-304
13. Tzen KY, Kao PF, Yen TC, et al: Imaging of dopamine transporters in the human brain in healthy and Parkinsons disease with 99Tcm-TRODAT-1 SPECT. J Nucl Med 1999; 40:27-30
14. Laine TP, Ahonen A, Rasanen P, et al: Dopamine transporter availability and depressive symptoms during alcohol withdrawal. Psychiatry Res 1999; 90:153-157
15. Leenders KL: Neuroimaging methods applied in Parkinson's disease. J Neurol 2004; 251(suppl 6): VI/7-VI/12
16. van Dyck CH, Seibyl JP, Malison RT, et al: Age-related decline in striatal dopamine transporter binding with iodine-123-beta-CIT SPECT. J Nucl Med 1995; 36:1175-1181
17. Remy P, Doder M, Lees A, et al: Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain 2005; 128:1314-1322
18. Meyer JH, Kruger S, Wilson AA, et al: Lower dopamine transporter binding potential in striatum during depression. Neuroreport 2001; 12:4121-4125
19. Argyelan M'Szabó Z, Kanyó B, et al: Dopamine transporter availability in medication free and in bupropion treated depression: a 99mTc-TRODAT-1 SPECT study. J Affect Disord 2005; 89:115-123
20. Brunswick DJ, Amsterdam JD, Mozley PD, et al: Greater availability of brain dopamine transporters in major depression shown by [99m Tc]TRODAT-1 SPECT imaging. Am J Psychiatry 2003,Oct 160:1836-1841
21. Laasonen-Balk T, Kuikka J, Viinamaki H, et al: Striatal dopamine transporter density in major depression. Psychopharmacology 1999; 144:282-285