Symposium 2: Micronutrients under the microscope: Aluminium exposure from parenteral nutrition in preterm infants and later health outcomes during childhood and adolescence

Proceedings of the Nutrition Society

Volumn 70, Issue 3, 2011, Pages 299-304

  Fewtrell, Mary S ^a   Edmonds, Caroline J ^b   Isaacs, Elizabeth ^a   Bishop, Nick J ^c   Lucas, Alan ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF EAST LONDON   (United Kingdom)

^c SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

Aluminium; Bone health; Cognitive outcome; Parenteral nutrition; Preterm

Indexed keywords

ALUMINUM; GLUCONATE CALCIUM; PARENTERAL SOLUTION;

ADOLESCENCE; ALUMINUM BLOOD LEVEL; ALUMINUM OVERLOAD; BONE MASS; CHILDHOOD; COGNITION; CONFERENCE PAPER; FOLLOW UP; FOOD AND DRUG ADMINISTRATION; HIP; HUMAN; LUMBAR SPINE; MALNUTRITION; NERVOUS SYSTEM DEVELOPMENT; NEUROLOGIC DISEASE; OUTCOME ASSESSMENT; PARENTERAL NUTRITION; PREMATURITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); TISSUE LEVEL; URINALYSIS; ADOLESCENT; ARTICLE; BONE DENSITY; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENVIRONMENTAL MONITORING; FOOD CONTAMINATION; GROWTH; GROWTH, DEVELOPMENT AND AGING; INFANT; METABOLISM; NERVOUS SYSTEM; NEWBORN; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ALUMINUM; BONE DENSITY; DOUBLE-BLIND METHOD; ENVIRONMENTAL MONITORING; FOLLOW-UP STUDIES; FOOD CONTAMINATION; GROWTH; HUMANS; INFANT; INFANT, NEWBORN; INFANT, PREMATURE; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; PARENTERAL NUTRITION; PARENTERAL NUTRITION SOLUTIONS;

EID: 80054930254     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665111000498     Document Type: Conference Paper

References (32)

1. Bishop NJ, Morley R, Day JP, et al. (1997) Aluminum neurotoxicity in preterm infants receiving intravenous-feeding solutions. New Engl J Med 336, 1557-1561
2. Burn DJ & Bates D (1998) Neurology and the kidney. J Neurol Neurosurg Psychiatry 65, 810-821
3. Cusamo F & Savazzi G (1986) Cerebral computed tomography in uremic hemodialyzed patients. J Comput Assist Tomogr 10, 567-570
4. McDermott JR, Smith AI, Ward MK, et al. (1978) Brainaluminium concentration in dialysis encephalopathy. Lancet 1 (8070), 901-904
5. Bolla KI, Briefel G, Spector D, et al. (1992) Neurocognitive effects of aluminium. Arch Neurol 49, 1021-1026
6. White DM, Longstreth WT, Rosenstock L, et al. (1992) Neurologic syndrome in 25 workers from an aluminium smelting plant. Arch Intern Med 152, 1443-1448
7. Ott SM, Maloney NA, Klein GL, et al. (1983) Aluminum is associated with low bone formation in patients receiving chronic parenteral nutrition. Ann Int Med 98, 910-914
8. Ott SM, Maloney NA, Coburn JW, et al. (1982) The prevalence of bone aluminium deposition in renal osteodystrophy and its relation to the response to calcitriol therapy. N Engl J Med 307, 709-713
9. Goodman WG, Gilligan J & Horst RL (1984) Short-term aluminium administration in the rat: effects on bone formation and relationship to renal osteomalacia. J Clin Invest 73, 171-181
10. Sedman AB, Alfrey AC, Miller NL, et al. (1987) Tissue and cellular basis for impaired bone formation in aluminiumrelated osteomalacia in the pig. J Clin Invest 79, 86-92
11. Goodman WG, Henry DA, Horst R, et al. (1984) Parenteral aluminium administration in the dog. II. Induction of osteomalacia and effect on vitamin D metabolism. Kidney Int 25, 370-375
12. Moreno A, Dominguez C & Ballabriga A (1994) Aluminum in the neonate related to parenteral nutrition. Acta Paediatr 83, 25-29
13. Mouser JF, Wu AH & Herson VC (1998) Aluminum contamination of neonatal parenteral nutrient solutions and additives. Am J Health Syst Pharm 55, 1071-1072
14. McGraw M, Bishop N, Jameson R, et al. (1986) Aluminum content of milk formulae and intravenous fluids used in infants. Lancet 1, 157
15. Sedman AB, Klein GL, Merritt RJ, et al. (1985) Evidence of aluminium loading in infants receiving intravenous therapy. New Engl J Med 312, 1337-1343
16. Bayley N (1969) Bayley Scales of Infant Development. New York: Psychological Corporation
17. Wechsler D (1999) Wechsler Abbreviated Scale of Intelligence Manual. San Antonio, TX: Harcourt Brace & Company
18. Wechsler D (1993) Wechsler Objectives Reading Dimensions Test. Sidcup, UK: Psychological Corporation
19. Wechsler D (1996) Wechsler Objectives Numerical Dimensions Test. Sidcup, UK: Psychological Corporation
20. Talley H (1993) Childrens Auditory Verbal Learning Test (CAVLT-2). Odessa, FL: Psychological Assessment Resources
21. Cohen M (1997) Childrens Memory Scale (CMS). Sidcup, UK: Psychological Corporation
22. Corsi PM (1972) Human memory and the medial temporal region of the brain. Unpublished doctoral dissertation, McGill University, Montreal, Canada
23. Emslie H, Wilson C, Burden V, et al. (2003) Behavioural Assessment of the Dysexecutive Syndrome in Children (BADS-C). Suffolk, UK: Thames Valley Test Company
24. Fewtrell MS, Bishop NJ, Edmonds CJ, et al. (2009) Aluminum exposure from parenteral nutrition in preterm infants: bone health at 15-year follow-up. Pediatrics 124, 1372-1379
25. Fewtrell MS (2006) Osteoporosis; is primary prevention possible? In Primary prevention by Nutrition Intervention in Infancy and Childhood, pp. 135-152 [A Lucas and HA Sampson, editors]. Nestle Nutrition Workshop Series Pediatric Program 57. Karger, Switzerland
26. Cirmanova V, Beyer M, Starka L, et al. (2008) The effect of leptin on bone - an evolving concept of action. J Bone Min Res 57, S143-S151
27. Elefteriou F (2008) Regulation of bone remodelling by the central and peripheral nervous system. Arch Biochem Biophys 473, 231-236
28. Hernandez CJ (2003) Theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis. Osteopos Int 14, 843-847
29. Food and Drug Administration (2003) Amendment of regulations on parenteral nutrition; delay of effective date. Fed Register 68, 32979-32981
30. Poole RL, Hintz SR, Mackenzie NI, et al. (2008) Aluminum exposure from pediatric parenteral nutrition: meeting the new FDA regulation. J Parenter Enteral Nutr 32, 242-246
31. Poole RL, Schiff L, Hintz SR, et al. (2010) Aluminum content of parenteral nutrition in neonates: measured versus calculated levels. J Pediatr Gastro Nutr 50, 208-211
32. MHRA Public Assessment Report (2010) Calcium gluconate injection 10% in 10ml glass containers: risk of aluminium exposure. http://www.mhra.gov.uk