Sulforaphane inhibits oral carcinoma cell migration and invasion In Vitro

Phytotherapy Research

Volumn 25, Issue 11, 2011, Pages 1623-1628

  Jee, Hyeon Gun ^a   Lee, Kyu Eun ^a   Kim, Jong Bin ^a   Shin, Hyo Keun ^b   Youn, Yeo Kyu ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

Invasion; Migration; Oral carcinoma; Sulforaphane

Indexed keywords

GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; METALLOPROTEINASE; PACLITAXEL; SULFORAPHANE; TETRAZOLIUM;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER INVASION; CARCINOMA CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME ASSAY; ENZYME RELEASE; IN VITRO STUDY; MIGRATION INHIBITION; MOUTH CARCINOMA; PROTEIN EXPRESSION;

CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOTHIOCYANATES; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; THIOCYANATES;

BRASSICA OLERACEA;

EID: 80054908055     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3397     Document Type: Article

References (18)

1. Annabi B, Rojas-Sutterlin S, Laroche M, Lachambre MP, Moumdjian R, Beliveau R. 2008. The diet-derived sulforaphane inhibits matrixmetalloproteinase-9-activated human brainmicrovascular endothelial cell migration and tubulogenesis. Mol Nutr Food Res 52: 692-700.
2. Cho NP, Han HS, Leem DH et al. 2009. Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model. Oral Oncol 45: 654-660.
3. Choi S, Singh SV. 2005. Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent. Cancer Res 65: 2035-2043. (Pubitemid 40478634)
4. Chung FL, Conaway CC, Rao CV, Reddy BS. 2000. Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 21: 2287-2291. (Pubitemid 32049237)
5. Deryugina EI, Quigley JP. 2006. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25: 9-34. (Pubitemid 43723979)
6. Fahey JW, Haristoy X, Dolan PM et al. 2002. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA 99: 7610-7615. (Pubitemid 34568739)
7. Hanlon N, Coldham N, Gielbert A et al. 2008. Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat. Br J Nutr 99: 559-564. (Pubitemid 351223423)
8. Higdon JV, Delage B, Williams DE, Dashwood RH. 2007. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res 55: 224-236. (Pubitemid 46518152)
9. Juge N, Mithen RF, Traka M. 2007. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci 64: 1105-1127. (Pubitemid 46684547)
10. Kademani D. 2007. Oral cancer. Mayo Clin Proc 82: 878-887. (Pubitemid 47015470)
11. Kallifatidis G, Rausch V, Baumann B et al. 2009. Sulforaphane targets pancreatic tumour-initiating cells by NF-{kappa}B-induced antiapoptotic signalling. Gut 58: 949-963.
12. Mehlen P, Puisieux A. 2006. Metastasis: a question of life or death. Nat Rev Cancer 6: 449-458.
13. Oganesian A, Hendricks JD, Williams DE. 1997. Long term dietary indole-3-carbinol inhibits diethylnitrosamine-initiated hepatocarcinogenesis in the infantmousemodel. Cancer Lett 118: 87-94. (Pubitemid 27397228)
14. Shankar S, Ganapathy S, Srivastava RK. 2008. Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis. Clin Cancer Res 14: 6855-6866.
15. Singh SV, Warin R, Xiao D et al. 2009. Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells. Cancer Res 69: 2117-2125.
16. Thejass P, Kuttan G. 2006. Antimetastatic activity of sulforaphane. Life Sci 78: 3043-3050.
17. Yao H, Wang H, Zhang Z, Jiang BH, Luo J, Shi X. 2008. Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells. Int J Cancer 123: 1255-1261.
18. Zhang Y, Talalay P, Cho CG, Posner GH. 1992. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA 89: 2399-2403.