Case study: to-BBB's G-Technology®, getting the best from drug-delivery research with industry-academia partnerships

Therapeutic Delivery

Volumn 2, Issue 11, 2011, Pages 1391-1394

  Gaillard, Pieter J ^a  

^a Bio Partner Center II   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; DRUG CARRIER; GLUTATHIONE; LIPOSOME; MACROGOL; METHYLPREDNISOLONE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BIOTECHNOLOGY; BLOOD BRAIN BARRIER; BRAIN METASTASIS; BREAST CANCER; CANCER CHEMOTHERAPY; CLINICAL EFFECTIVENESS; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG INDUSTRY; DRUG RESEARCH; DRUG SAFETY; EPILEPSY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUNTINGTON CHOREA; INTERDISCIPLINARY RESEARCH; LIPOSOMAL DELIVERY; LYSOSOME STORAGE DISEASE; MULTIPLE SCLEROSIS; NEOPLASM; NERVOUS SYSTEM INFLAMMATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PUBLIC-PRIVATE PARTNERSHIP;

EID: 80054882935     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.11.111     Document Type: Article

References (16)

1. Gaillard PJ. Crossing barriers from blood-to-brain and academia-to-industry. Therapeutic Delivery 1(4), 495-500 (2010).
2. Kannan R, Kuhlenkamp JF, Jeandidier E et al. Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat. J. Clin. Invest. 85(6), 2009-2013 (1990).
3. Kannan R, Mittur A, Bao Y, Tsuruo T, Kaplowitz N. GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter. J. Neurochem. 73(1), 390-399 (1999).
4. Kannan R, Yi JR, Tang D et al. Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from γ-glutamyltranspeptidase and facilitative GSH transporters. J. Biol. Chem. 271(16), 9754-9758 (1996).
5. Zlokovic BV, Mackic JB, McComb JG et al. Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem. Biophys. Res. Commun. 201(1), 402-408 (1994).
6. Gaillard PJ, Visser CC, Appeldoorn CCM, Rip J. Blood-to-brain drug delivery - 10 key development criteria. Curr. Pharm. Biotechnol. (2011) (In press).
7. Rip J, Appeldoorn CCM, Manca FM et al. Receptor-mediated delivery of drugs across the blood-brain barrier. Presented at: Pharmacology and Toxicology of the Blood-Brain Barrier: State of the Art, Needs for Future Research and Expected Benefits for the EU. Brussels, Belgium, 11-12 February 2010.
8. van Tellingen O, Brandsma D, Appeldoorn CCM et al. GSH-conjugation improves efficacy of Doxil against intracranial xenografts. Presented at: 101st Annual Meeting of the American Association for Cancer Research. Washington DC, PA, USA, 17-21 April 2010.
9. van Tellingen O, Brandsma D, Boogerd W et al. GSH-conjugation improves efficacy of doxil against intractranial xenografts. Neuro-Oncology 12(Suppl. 3), iii34 (2010).
10. Gaillard PJ, Leyssen P, Appeldoorn C et al. Development of brain-targeted liposomes with antiviral drugs for treating lethal viral encephalitis. Presented at: 8th International Conference on Cerebral Vascular Biology. Sendai, Japan, 28 June-2 July 2009.
11. Appeldoorn CCM, Gaillard PJ, Rip J et al. Enhanced brain delivery of liposomal methylprednisolone is beneficial for the treatment of neuroinflammation in EAE. Presented at: 9th International Conference on Cerebral Vascular Biology. Leiden, the Netherlands, 21-25 June 2011.
12. Gaillard PJ, Appeldoorn CCM, Gladdines W et al. Development of glutathione PEGylated liposomal doxorubicin (2B3-101) for the treatment of brain metastases from breast cancer. Presented at: 9th International Conference on Cerebral Vascular Biology. Leiden, the Netherlands, 21-25 June 2011.
13. Rip J, Chen L, van Kregten J et al. In vitro evaluation and optimization of drug delivery from glutathione-conjugated PEG coated liposomes. Presented at: 9th International Conference on Cerebral Vascular Biology. Leiden, the Netherlands, 21-25 June 2011.
14. Gaillard PJ, Appeldoorn CCM, Gladdines W et al. Development of glutathione PEGylated liposomal doxorubicin (2B3-101) for the treatment of brain metastases from breast cancer. Presented at: 4th European Conference for Clinical Nanomedicine. Basel, Switzerland, 23-25 May 2011.
15. Industrial Technology Research Institute: US0141133 (2005).
16. ClinicalTrials. NCT01386580.http://clinicaltrials.gov/ct2/show/ NCT01386580