To escalate or to de-escalte-That is the question

Critical Care Medicine

Volumn 39, Issue 11, 2011, Pages 2590-

  Schuetz, Philipp ^a   Mueller, Beat ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PROCALCITONIN;

ANTIBIOTIC THERAPY; ARTIFICIAL VENTILATION; CLINICAL PRACTICE; CRITICALLY ILL PATIENT; DISEASE SEVERITY; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; GOLD STANDARD; INTENSIVE CARE UNIT; LABORATORY TEST; LETTER; MORTALITY; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEPSIS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 80054879711     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31822a5ddf     Document Type: Letter

References (9)

1. Jensen JU, Hein L, Lundgren B, et al: Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial. Crit Care Med 2011; 39:2048-2058
2. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, et al: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360:1283-1297
3. Sprung CL, Annane D, Keh D, et al: Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008; 358:111-124
4. Jensen JU, Heslet L, Jensen TH, et al: Procalcitonin increase in early identification of critically ill patients at high risk of mortality. Crit Care Med 2006; 34:2596-2602 (Pubitemid 44413058)
5. Müller B, Becker KL, Schächinger H, et al: Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med 2000; 28:977-983
6. Harbarth S, Holeckova K, Froidevaux C, et al: Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Resp Crit Care Med 2001; 164:396-402 (Pubitemid 32778205)
7. Bouadma L, Luyt CE, Tubach F, et al: Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): A multicentre randomised controlled trial. Lancet 2010; 375:463-474
8. Schuetz P, Albrich W, Christ-Crain M, et al: Procalcitonin for guidance of antibiotic therapy. Expert Rev Anti Infect Ther 2010; 8:575-587
9. Schuetz P, Christ-Crain M, Thomann R, et al: Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: The ProHOSP randomized controlled trial. JAMA 2009; 302:1059-1066