Abnormal negative feedback processing in first episode schizophrenia: Evidence from an oculomotor rule switching task

Psychological Medicine

Volumn 41, Issue 9, 2011, Pages 1805-1814

  Huddy, V C ^a   Hodgson, T L ^b   Ron, M A ^c   Barnes, T R E ^d   Joyce, E M ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Cognitive impairments; executive function; eye movements; reward processing; schizophrenia; working memory

Indexed keywords

ADAPTIVE BEHAVIOR; ADULT; ARTICLE; ASSOCIATION; ATTENTION; FEMALE; HUMAN; MALE; MENTAL FUNCTION; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PATTERN RECOGNITION; PSYCHOLOGY; REACTION TIME; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; TASK PERFORMANCE;

ADULT; ATTENTION; CUES; FEEDBACK, PSYCHOLOGICAL; FEMALE; HUMANS; MALE; MENTAL PROCESSES; NEUROPSYCHOLOGICAL TESTS; PATTERN RECOGNITION, VISUAL; REACTION TIME; SACCADES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TASK PERFORMANCE AND ANALYSIS; YOUNG ADULT;

EID: 80054873408     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291710002527     Document Type: Article

References (63)

1. Abi-Dargham A, Rodenhiser J, Printz D, Zea-Ponce Y, Gil R, Kegeles LS, Weiss R, Cooper B, Mann JJ, Van Heertum RL, Gorman JM, Laruelle M (2000). Increased baseline occupancy of D-2 receptors by dopamine in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 97, 8104-8109. (Pubitemid 30460780)
2. Andreasen NC (1983). The Scale for the Assessment of Negative Symptoms (SANS). The University of Iowa: Iowa City, Iowa.
3. Andreasen N (1984). The Scale for the Assessment of Positive Symptoms (SAPS). The University of Iowa: Iowa City, IA.
4. Anden NE, Butcher SG, Corrodi H, Fuxe K, Ungerstedt U (1970). Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. European Journal of Pharmacology 11, 303-314.
5. Aron AR, Fletcher PC, Bullmore ET, Sahakian BJ, Robbins TW (2003). Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans. Nature Neuroscience 6, 115-116. (Pubitemid 36182778)
6. Aron AR, Robbins TW, Poldrack RA (2004). Inhibition and the right inferior frontal cortex. Trends in Cognitive Sciences 8, 170-177. (Pubitemid 38429927)
7. Berman KF, Ostrem JL, Randolph C, Gold J, Goldberg TE, Coppola R, Carson RE, Herscovitch P, Weinberger DR (1995). Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test-a positron emission tomography study. Neuropsychologia 33, 1027-1046.
8. Blyler CR, Gold JM, Iannone VN, Buchanan RW (2000). Short form of the 'WAIS-III for use with patients with schizophrenia. Schizophrenia Research 46, 209-215.
9. Carter CS, Barch DM, Buchanan RW, Bullmore E, Krystal JH,CohenJ,GeyerM,GreenM,Nuechterlein KH, Robbins T, Silverstein S, Smith EF, Strauss M, Wykes T, Heinssen R (2008). Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognitionin Schizophrenia Initiative. Biological Psychiatry 64, 4-10.
10. Corlett PR, Murray GK, Honey GD, Aitken MRF, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC (2007). Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain 130, 2387-2400. (Pubitemid 47327635)
11. Creese I, Burt DR, Snyder SH (1976). Dopamine receptor-binding predicts clinical and pharmacological potencies of anti-schizophrenic drugs. Science 192, 481-483.
12. Dickinson D, Harvey PD (2009). Systemic hypotheses for generalized cognitive deficits in schizophrenia: a new take on an old problem. Schizophrenia Bulletin 35, 403-414.
13. Franke C, Reuter B, Schulz L, Kathmann N (2007). Schizophrenia patients show impaired response switching in saccade tasks. Biological Psychology 76, 91-99. (Pubitemid 47271953)
14. Fukushima J, Fukushima K, Chiba T, Tanaka S, Yamashita I, Kato M (1988). Disturbances of voluntary control of saccadic eye movements in schizophrenic patients. Biological Psychiatry 23, 670-677. (Pubitemid 18086646)
15. Gold JM, Waltz JA, Prentice KJ, Morris SE, Heerey EA (2008). Reward processing in schizophrenia: a deficit in the representation of value. Schizophrenia Bulletin 34, 835-847.
16. Goldberg TE, Weinberger DR (1994). Schizophrenia, training paradigms, and the Wisconsin Card Sorting Test Redux. Schizophrenia Research 11, 291-296. (Pubitemid 24063750)
17. Grant DA, Berg EA (1948). A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. Journal of Experimental Psychology 38, 404-411.
18. Greenzang C, Manoach DS, Goff DC, Barton JJS (2007). Task-switching in schizophrenia: active switching costs and passive carry-over effects in an antisaccade paradigm. Experimental Brain Research 181, 493-502. (Pubitemid 47077045)
19. Guitton D, Buchtel HA, Douglas RM (1985). Frontal-lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades. Experimental Brain Research 58, 455-472. (Pubitemid 15041280)
20. Hallett PE, Adams BD (1980). The predictability of saccadic latency in a novel voluntary oculomotor task. Vision Research 20, 329-339. (Pubitemid 10065068)
21. Heerey EA, Robinson BM, McMahon RP, Gold JM (2007). Delay discounting in schizophrenia. Cognitive Neuropsychiatry 12, 213-221. (Pubitemid 46598194)
22. Hodgson T, Chamberlain M, Parris B, James M, Gutowski N, Husain M, Kennard C (2007). The role of the ventrolateral frontal cortex in inhibitory oculomotor control. Brain 130, 1525-1537. (Pubitemid 47355918)
23. Hodgson TL, Golding C, Molyva D, Rosenthal CR, Kennard C (2004). Eye movements during task switching: reflexive, symbolic, and affective contributions to response selection. Journal of Cognitive Neuroscience 16, 318-330. (Pubitemid 38299802)
24. Hodgson TL, Mort D, Chamberlain MM, Hutton SB, O'Neill KS, Kennard C (2002). Orbitofrontal cortex mediates inhibition of return. Neuropsychologia 40, 1891-1901.
25. Huddy VC, Aron AR, Harrison M, Barnes TRE, Robbins TW, Joyce EM (2009). Impaired conscious and preserved unconscious inhibitory processing in recent onset schizophrenia. Psychological Medicine 39, 907-916.
26. Huddy VC, Hodgson TL, Kapasi M, Mutsatsa SH, Harrison I, Barnes TRE, Joyce EM (2007). Gaze strategies during planning in first-episode psychosis. Journal of Abnormal Psychology 116, 589-598. (Pubitemid 47444694)
27. Hunt AR, Klein RM (2002). Eliminating the cost of task set reconfiguration. Memory & Cognition 30, 529-539. (Pubitemid 34832957)
28. Hunt AR, Olk B, von Muhlenen A, Kingstone A (2004). Integration of competing saccade programs. Cognitive Brain Research 19, 206-208. (Pubitemid 38328754)
29. Husain M, Parton A, Hodgson TL, Mort D, Rees G (2003). Self-control during response conflict by human supplementary eye field. Nature Neuroscience 6, 117-118. (Pubitemid 36182779)
30. Hutton SB, Ettinger U (2006). The antisaccade task as a research tool in psychopathology: a critical review. Psychophysiology 43, 302-313. (Pubitemid 43927348)
31. Hutton SB, Puri BK, Duncan L-J, Robbins TW, Barnes TRE, Joyce EM (1998). Executive function in first-episode schizophrenia. Psychological Medicine 28, 463-473. (Pubitemid 28197561)
32. Jablensky A, Sartorius N, Ernberg G, Anker M, Korten A, Cooper JE, Day R, Bertelsen A (1992). Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten country study. Psychological Medicine (Mongraph Supplement) 20, 1-97.
33. Kaladjian A, Jeanningros R, Azorin JM, Grimault S, Anton JL, Mazzola-Pomietto P (2007). Blunted activation in right ventrolateral prefrontal cortex during motor response inhibition in schizophrenia. Schizophrenia Research 97, 184-193. (Pubitemid 350088390)
34. Kapur S (2003). Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. American Journal of Psychiatry 160, 13-23. (Pubitemid 36042420)
35. Leeson V, Robbins TW, Matheson E, Hutton SB, Ron M, Barnes TRE, Joyce EM (2009). Discrimination learning, reversal and set-shifting in first episode schizophrenia: stability over six years and specific associations with medication type and disorganisation syndrome. Biological Psychiatry 15, 586-593.
36. Li C, Park S (2004). Do schizophrenia patients make more perseverative than non-perseverative errors on the Wisconsin Card Sorting Test? A meta-analytic study. Psychiatry Research 129, 179-190. (Pubitemid 39601814)
37. Manoach DS, Lindgren KA, Cherkasova MV, Goff DC, Halpern EF, Intriligator J, Barton JJ (2002). Schizophrenic subjects show deficient inhibition but intact task switching on saccadic tasks. Biological Psychiatry 51, II.
38. Meiran N, Levine J, Meiran N, Henik A (2000). Task set switching in schizophrenia. Neuropsychology 14, 471-482.
39. Monsell S (2003). Task switching. Trends in Cognitive Sciences 7, 134-140. (Pubitemid 36294174)
40. Murray GK, Cheng F, Clark L, Barnett JH, Blackwell AD, Fletcher PC, Robbins TW, Bullmore ET, Jones PB (2008). Reinforcement and reversal learning in first-episode psychosis. Schizophrenia Bulletin 34, 848-855.
41. Nelson HE (1976). Modified card sorting rest sensitive to frontal lobe defects. Cortex 12, 313-324. (Pubitemid 8008480)
42. Nobre AC, Coull JT, Frith CD, Mesulam MM (1999). Orbitofrontal cortex is activated during breaches of expectation in tasks of visual attention. Nature Neuroscience 2, 11-12. (Pubitemid 30488933)
43. Owen AM, Downes JJ, Sahakian BJ, Polkey CE, Robbins TW (1990). Planning and spatial working memory following frontal-lobe lesions in man. Neuropsychologia 28, 1021-1034. (Pubitemid 20347464)
44. Pantelis C, Barnes TRE, Nelson HE, Tanner S, Weatherley L, Owen AM, Robbins TW (1997). Fronto-striatal cognitive deficits in patients with chronic schizophrenia. Brain 120, 1823-1843. (Pubitemid 27443056)
45. Parton A, Nachev P, Hodgson TL, Mort D, Thomas D, Ordidge R, Morgan P, Jackson S, Rees G, Husain M (2007). Role of the human supplementary eye field in the control of saccadic eye movements. Neuropsychologia 45, 997-1008. (Pubitemid 44958774)
46. Polli FE, Barton JJS, Vangel M, Goff DC, Iguchi L, Manoach DS (2006). Schizophrenia patients show intact immediate error-related performance adjustments on an antisaccade task. Schizophrenia Research 82, 191-201. (Pubitemid 43290683)
47. Posner MI, Rafal RD, Choate LS, Vaughan J (1985). Inhibition of return: neural basis and function. Cognitive Neuropsychology 2, 211-238.
48. Prentice KJ, Gold JM, Buchanan RW (2008). The Wisconsin Card Sorting impairment in schizophrenia is evident in the first four trials. Schizophrenia Research 106, 81-87.
49. Reuter B, Jager M, Bottlender R, Kathmann N (2007). Impaired action control in schizophrenia: the role of volitional saccade initiation. Neuropsychologia 45, 1840-1848. (Pubitemid 46386108)
50. Reuter B, Kathmann N (2004). Using saccade tasks as a tool to analyze executive dysfunctions in schizophrenia. Acta Psychologica 115, 255-269. (Pubitemid 38169816)
51. Schultz W, Dickinson A (2000). Neuronal coding of prediction errors. Annual Review of Neuroscience 23, 473-500. (Pubitemid 30350051)
52. Seeman P, Chau-Wong M, Tedesco J, Wong K (1976). Dopamine receptors in human and calf brains, using [3H]apomorphine and an antipsychotic drug. Proceedings of the National Academy of Science 73, 4354-4358. (Pubitemid 8013974)
53. Swainson R, Rogers RD, Sahakian BJ, Summers BA, Polkey CE, Robbins TW (2000). Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. Neuropsychologia 38, 596-612. (Pubitemid 30109440)
54. Takahashi YK, Roesch MR, Stalnaker TA, Haney RZ, Calu DJ, Taylor AR, Burke KA, Schoenbaum G (2009). The orbitofrontal cortex and ventral tegmental area are necessary for learning from unexpected outcomes. Neuron 62, 269-280.
55. Tremblay L, Schultz W (2000). Reward-related neuronal activity during go-nogo task performance in primate orbitofrontal cortex. Journal of Neurophysiology 83, 1864-1876. (Pubitemid 30198643)
56. Waelti P, Dickinson A, Schultz W (2001). Dopamine responses comply with basic assumptions of formal learning theory. Nature 412, 43-48. (Pubitemid 32851502)
57. Walker R, Husain M, Hodgson TL, Harrison J, Kennard C (1998). Saccadic eye movement and working memory deficits following damage to human prefrontal cortex. Neuropsychologia 36, 1141-1159. (Pubitemid 28529534)
58. Waltz JA, Gold JM (2007). Probabilistic reversal learning impairments in schizophrenia: Further evidence of orbitofrontal dysfunction. Schizophrenia Research 93, 296-303. (Pubitemid 46817948)
59. Wechsler D (1999). Wechsler Adult Intelligence Scale-third edn. Psychological Corporation: London.
60. Wechsler D (2001). Wechsler Test of Adult Reading-3rd edn. Psychological Corporation: London.
61. Weinberger DR, Berman KF, Zec RF (1986). Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. 1. Regional cerebral blood-flow evidence. Archives of General Psychiatry 43, 114-124. (Pubitemid 16163530)
62. Woodberry KA, Giuliano AJ, Seidman LJ (2008). Premorbid IQ in schizophrenia: a meta-analytic review. American Journal of Psychiatry 165, 579-587. (Pubitemid 351705334)
63. Wykes T, Reeder C, Landau S, Everitt B, Knapp M, Patel A, Romeo R (2007). Cognitive remediation therapy in schizophrenia: randomised controlled trial. British Journal of Psychiatry 190, 421-427. (Pubitemid 46706955)