Stepwise increase of angiopoietin-2 serum levels is related to haemodynamic and functional impairment in stable chronic heart failure

European Journal of Preventive Cardiology

Volumn 18, Issue 4, 2011, Pages 607-614

  Eleuteri, Ermanno ^a   di Stefano, Antonino ^a   Tarro Genta, Franco ^b   Vicari, Chiara ^a   Gnemmi, Isabella ^a   Colombo, Marilena ^a   Mezzani, Alessandro ^a   Giannuzzi, Pantaleo ^a  

^a IRCCS   (Italy)

^b Clinica Major   (Italy)

Author keywords

Endothelial dysfunction; inflammation; oxidative stress

Indexed keywords

ANGIOGENIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; BRAIN NATRIURETIC PEPTIDE; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FUNCTIONAL DISEASE; HEART FAILURE; HEART HEMODYNAMICS; HUMAN; MAJOR CLINICAL STUDY; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; WALKING;

AGED; ANALYSIS OF VARIANCE; ANGIOPOIETIN-1; ANGIOPOIETIN-2; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHRONIC DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART FAILURE; HEMODYNAMICS; HUMANS; ITALY; MALE; MIDDLE AGED; NATRIURETIC PEPTIDE, BRAIN; NEOVASCULARIZATION, PHYSIOLOGIC; OXYGEN CONSUMPTION; PEPTIDE FRAGMENTS; RECEPTOR, TIE-2; REGRESSION ANALYSIS; RIBONUCLEASE, PANCREATIC; SEVERITY OF ILLNESS INDEX; STROKE VOLUME; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENTRICULAR FUNCTION, LEFT;

EID: 80054868438     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1177/1741826710389410     Document Type: Article

References (21)

1. Felmeden DC, Blann AD, Lip GY. Angiogenesis: basic pathophysiology and implications for disease. Eur Heart J 2003; 24: 586–603.
2. Prescott E, Hjardem-Hansen R, Dela F, Ørkild B, Teisner AS, Nielsen H. Effects of a 14-month low-cost maintenance training program in patients with chronic systolic heart failure: a randomized study. Eur J Cardiovasc Prev Rehabil 2009; 16: 430–437.
3. Gielen S, Adams V, Linke A, Erbs S, Mobius-Winkler S, Schubert A, et al. Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle. Eur J Cardiovasc Prev Rehabil 2005; 12: 393–400.
4. Chin BS, Chung NA, Gibbs CR, Blann AD, Lip GY. Vascular endothelial growth factor and soluble P-selectin in acute and chronic congestive heart failure. Am J Cardiol 2002; 90: 1258–1260.
5. Chong AY, Caine GJ, Freestone B, Blann AD, Lip GY. Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure. J Am Coll Cardiol 2004; 43: 423–428.
6. Patel JV, Sosin M, Gunarathne A, Hussain I, Davis RC, Hughes EA, et al. Elevated angiogenin levels in chronic heart failure. Ann Med 2008; 40: 474–479.
7. Eleuteri E, Di Stefano A, Ricciardolo FL, Magno F, Gnemmi I, Colombo M, et al. Increased nitrotyrosine plasma levels in relation to systemic markers of inflammation and myeloperoxidase in chronic heart failure. Int J Cardiol 2009; 135: 386–390.
8. La Rocca G, Di Stefano A, Eleuteri E, Anzalone R, Magno F, Corrao S, et al. Oxidative stress induces myeloperoxidase expression in endocardial endothelial cells from patients with chronic heart failure. Basic Res Cardiol 2009; 104: 307–320.
9. Chong AY, Caine GJ, Lip GY. Angiopoietin/tie-2 as mediators of angiogenesis: a role in congestive heart failure? Eur J Clin Invest 2004; 34: 9–13.
10. Asahara T, Chen D, Takahashi T, Fujikawa K, Kearney M, Magner M, et al. Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res 1998; 83: 233–240.
11. Tello-Montoliu A, Patel JV, Lip GY. Angiogenin: a review of the pathophysiology and potential clinical applications. J Thromb Haemost 2006; 4: 1864–1874.
12. Giannuzzi P, Imparato A, Temporelli PL, De Vito F, Silva PL, Scapellato F, et al. Doppler-derived mitral deceleration time of early filling as a strong predictor of pulmonary capillary wedge pressure in postinfarction patients with left ventricular systolic dysfunction. J Am Coll Cardiol 1994; 23: 1630–1637.
13. Temporelli PL, Scapellato F, Corrà U, Eleuteri E, Firstemberg MS, Thomas JD, et al. Chronic mitral regurgitation and Doppler estimation of left ventricular filling pressures in patients with heart failure. J Am Soc Echocardiogr 2001; 14: 1094–1099.
14. Temporelli PL, Scapellato F, Eleuteri E, Imparato A, Giannuzzi P. Doppler echocardiography in advanced systolic heart failure: a noninvasive alternative to Swan-Ganz catheter. Circ Heart Fail 2010; 3: 387–394.
15. Thurston G. Complementary actions of VEGF and angiopoietin-1 on blood vessel growth and leakage. J Anat 2002; 200: 575–580.
16. Fiedler U, Augustin HG. Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol 2006; 27: 552–558.
17. Kim I, Kim HG, Moon SO, Chae SW, So J-N, Koh KN, et al. Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion. Circ Res 2000; 86: 952–959.
18. Ramsauer M, D’Amore PA. Getting Tie(2)d up in angiogenesis. J Clin Invest 2002; 110: 1615–1617.
19. Meng R, Pei Z, Chen B, Ma R, Zhang C, Chen B, et al. Age-related change of serum angiogenic factor levels in patients with coronary artery disease. Acta Cardiol 2009; 64: 735–740.
20. Ingle L, Rigby AS, Nabb S, Jones PK, Clark AL, Cleland JG. Clinical determinants of poor six-minute walk test performance in patients with left ventricular systolic dysfunction and no major structural heart disease. Eur J Heart Fail 2006; 8: 321–325.
21. Kümpers P, Lukasz A, David S, Horn R, Hafer C, Faulhaber-Walter R, et al. Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. Crit Care 2008; 12: R147–R147.