Characterisation of rodent dobutamine echocardiography for preclinical safety pharmacology assessment

Journal of Pharmacological and Toxicological Methods

Volumn 64, Issue 2, 2011, Pages 129-133

  Tontodonati, Marcello ^a   Fasdelli, Nicola ^b   Repeto, Paolo ^b   Dorigatti, Roberto ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Aptuit Inc   (United States)

Author keywords

Cardiac performance; Contractility; Dobutamine; Echocardiography; Infusion; Inotropism; Intravenous; Method; Pharmacological stress; Rat

Indexed keywords

DOBUTAMINE; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA FLOW; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG RESEARCH; DRUG SAFETY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE SEPTUM; INOTROPISM; MALE; NONHUMAN; PHARMACOLOGIC STRESS TESTING; RAT; STRESS ECHOCARDIOGRAPHY;

ANIMALS; DOBUTAMINE; DRUG EVALUATION, PRECLINICAL; ECHOCARDIOGRAPHY, STRESS; INFUSIONS, INTRAVENOUS; MALE; MYOCARDIAL CONTRACTION; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

ANIMALIA; RATTUS; RODENTIA;

EID: 80054865196     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2011.04.005     Document Type: Article

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