Activation of c-Jun N-terminal kinase 1/2 regulated by nitric oxide is associated with neuronal survival in hippocampal neurons in a rat model of ischemia

Chinese Medical Journal

Volumn 124, Issue 20, 2011, Pages 3367-3372

  Zeng, Xian Wei ^a   Li, Ming Wei ^b   Pan, Jing ^c   Ji, Tai Ling ^a   Yang, Bin ^a   Zhang, Bo ^a   Wang, Xiao Qiang ^c  

^a WEIFANG MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

2 amino 5; 6 dihydro methylthiazine; 7 nitroindazole; C jun n terminal kinase 1 2; Cerebral ischemia; Nitric oxide

Indexed keywords

2 AMINO 5,6 DIHYDROMETHYLTHIAZINE; 7 NITROINDAZOLE; CRYSTAL VIOLET; DIMETHYL SULFOXIDE; MITOGEN ACTIVATED PROTEIN KINASE 9; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HIPPOCAMPAL CA1 REGION; MALE; NEURONAL SURVIVAL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN ISCHEMIA; ENZYME INHIBITORS; HIPPOCAMPUS; INDAZOLES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 80054859186     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.20.029     Document Type: Article

References (20)

1. Burns JD, Manno EM. Primary intracerebral hemorrhage: update on epidemiology, pathophysiology, and treatment strategies. Compr Ther 2008; 34: 183-195.
2. Talelli P, Greenwood RJ. Recurrent stroke: where do we stand with the secondary prevention of noncardio embolic ischaemic strokes? Ther Adv Cardiovasc Dis 2008; 2: 387-405.
3. Wechsler LR. Intravenous thrombolytic therapy for acute ischemic stroke. N Engl J Med 2011; 364: 2138-2146.
4. Guiraud V, Amor MB, Mas JL, Touzé E. Triggers of ischemic stroke: a systematic review. Stroke 2010; 41: 2669-2677.
5. Tripathi A, Sodhi A. Growth hormone-induced production of cytokines in murine peritoneal macrophages in vitro: role of JAK/STAT, PI3K, PKC and MAP kinases. Immunobiology 2009; 214: 430-440.
6. Park HS, Huh SH, Kim MS, Lee SH, Choi EJ. Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation. Proc Natl Acad Sci U S A 2000; 97: 14382-14387.
7. Pan J, Zhang QG, Zhang GY. The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region. Neuroscience 2005; 131: 147-159.
8. Hu BR, Liu CL, Park DJ. Alteration of MAP kinase pathways after transient forebrain ischemia. J Cereb Blood Flow Metab 2000; 20: 1089-1095.
9. Li H, Forstermann U. Nitric oxide in the pathogenesis of vascular disease. J Pathol 2000; 190: 244-254.
10. Kunz A, Park L, Abe T. Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. J Neurosci 2007; 27: 7083-7093.
11. Fabian RH, Perez-Polo JR, Kent TA. Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia. Am J Physiol Heart Circ Physiol 2008; 295: 1809-1814.
12. Pei DS, Song YJ, Yu HM, Hu WW, Du Y, Zhang GY. Exogenous nitric oxide negatively regulates c-Jun N-terminal kinase activation via inhibiting endogenous NO-induced S-nitrosylation during cerebral ischemia and reperfusion in rat hippocampus. J Neurochem 2008; 106: 1952-1963.
13. Pan J, Pei DS, Yin XH, Hui L, Zhang GY. Involvement of oxidative stress in the rapid Akt1 regulating a JNK scaffold during ischemia in rat hippocampus. Neurosci Lett 2006; 392: 47-51.
14. Pei DS, Wang XT, Liu Y, Sun YF, Guan QH, Wang W, et al. Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence. Brain 2006; 129: 465-479.
15. Pan J, Wang G, Yang HQ, Hong Z, Xiao Q, Ren RJ, et al. K252a prevents nigral dopaminergic cell death induced by 6-hydroxydopamine through inhibition of both mixed-lineage kinase 3/c-Jun NH2-terminal kinase 3 (JNK3) and apoptosis-inducing kinase 1/JNK3 signaling pathways. Mol Pharmacol 2007; 72: 1607-1618.
16. Dong Y, Liu HD, Zhao R, Yang CZ, Chen XQ, Wang XH, et al. Ischemia activates JNK/c-Jun/AP-1 pathway to up-regulate 14-3-3gamma in astrocyte. J Neurochem 2009; 109 Suppl 1: 182-188.
17. Zhang T, Yang D, Fan Y, Xie P, Li H. Epigallocatechin- 3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways. Apoptosis 2009; 14: 1245-1254.
18. Sato S, Tominaga T, Ohnishi T, Ohnishi ST. Electron paramagnetic resonance study on nitric oxide production during brain focal ischemia and reperfusion in the rat. Brain Res 1994; 647: 91-96.
19. Choi YB, Tenneti L, Le DA, Ortiz J, Bai G, Chen HS, et al. Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nat Neurosci 2000; 3: 15-21.
20. Tian H, Zhang G, Li H, Zhang Q. Antioxidant NAC and AMPA/KA receptor antagonist DNQX inhibited JNK3 activation following global ischemia in rat hippocampus. Neurosci Res 2003; 46: 191-197.