Effects of lowering dialysate calcium concentrations on arterial stiffness in patients undergoing hemodialysis

Korean Journal of Internal Medicine

Volumn 26, Issue 3, 2011, Pages 320-327

  Kim, Jwa Kyung ^a   Moon, Sung Jin ^b   Park, Hyeong Cheon ^a   Lee, Jae Sung ^a   Sim, Soung Rok ^a   Bae, Sung Chang ^a   Ha, Sung Kyu ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Kwandong University College of Medicine   (South Korea)

Author keywords

Arterial stiffness; Calcium; Dialysis solutions; Fetuin a; Hemodialysis

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FETUIN A;

ADULT; AGED; ARTERIAL STIFFNESS; ARTICLE; AUGMENTATION INDEX; BIOCHEMISTRY; CALCIUM BLOOD LEVEL; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); DIALYSATE; FEMALE; FEMORAL ARTERY; FETUIN A BLOOD LEVEL; HEMODIALYSIS; HEMODIALYSIS PATIENT; HEMODYNAMICS; HUMAN; HYPERTENSION; MAINTENANCE THERAPY; MALE; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PULSE WAVE; THERAPY EFFECT;

AGED; ALPHA-2-HS-GLYCOPROTEIN; ANALYSIS OF VARIANCE; ANKLE BRACHIAL INDEX; ARTERIES; BIOLOGICAL MARKERS; BLOOD PRESSURE; CALCIUM; COMPLIANCE; FEMALE; HEMODIALYSIS SOLUTIONS; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PULSATILE FLOW; RENAL DIALYSIS; REPUBLIC OF KOREA; TIME FACTORS; TREATMENT OUTCOME;

EID: 80054847775     PISSN: 12263303     EISSN: 20056648     Source Type: Journal    
DOI: 10.3904/kjim.2011.26.3.320     Document Type: Article

References (27)

1. Kundhal K, Lok CE. Clinical epidemiology of cardiovascular disease in chronic kidney disease. Nephron Clin Pract 2005;101:c47-c52.
2. Sigrist MK, Levin A, Er L, McIntyre CW. Elevated osteoprote- gerin is associated with all-cause mortality in CKD stage 4 and 5 patients in addition to vascular calcification. Nephrol Dial Transplant 2009;24:3157-3162.
3. Demirci MS, Ozkahya M, Asci G, et al. The influence of dialysate calcium on progression of arterial stiffness in peritoneal dialysis patients. Perit Dial Int 2009;29 Suppl 2:S15-S17.
4. Essalihi R, Zandvliet ML, Moreau S, et al. Distinct effects of amlodipine treatment on vascular elastocalcinosis and stiffness in a rat model of isolated systolic hypertension. J Hypertens 2007;25:1879-1886.
5. Speer G, Fekete BC, El Hadj Othmane T, et al. Serum osteoprotegerin level, carotid-femoral pulse wave velocity and cardiovascular survival in haemodialysis patients. Nephrol Dial Transplant 2008;23:3256-3262.
6. Nakamura U, Iwase M, Nohara S, Kanai H, Ichikawa K, Iida M. Usefulness of brachial-ankle pulse wave velocity measurement: correlation with abdominal aortic calcification. Hypertens Res 2003;26:163-167.
7. Giachelli CM. Vascular calcification mechanisms. J Am Soc Nephrol 2004;15:2959-2964.
8. Yoo SJ, Oh DJ, Yu SH. The effects of low calcium dialysate on arterial compliance and vasoactive substances in patients with hemodialysis. Korean J Intern Med 2004;19:27-32.
9. Gotch F, Levin NW, Kotanko P. Calcium balance in dialysis is best managed by adjusting dialysate calcium guided by kinetic modeling of the interrelationship between calcium intake, dose of vitamin D analogues and the dialysate calcium concentration. Blood Purif 2010;29:163-176.
10. Kyriazis J, Katsipi I, Stylianou K, Jenakis N, Karida A, Daphnis E. Arterial stiffness alterations during hemodialysis: the role of dialysate calcium. Nephron Clin Pract 2007;106:c34-c42.
11. LeBeouf A, Mac-Way F, Utescu MS, et al. Effects of acute variation of dialysate calcium concentrations on arterial stif fness and aor tic pressure waveform. Nephrol Dial Transplant 2009;24:3788-3794.
12. Goldsmith D, Ritz E, Covic A. Vascular calcification: a stiff challenge for the nephrologist: does preventing bone disease cause arterial disease? Kidney Int 2004;66:1315-1333.
13. Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007;20:103-109.
14. Adragao T, Frazao JM. Cardiovascular risk in dialysis patients: an X-ray vision on vascular calcifications. Kidney Int 2008;74:1505-1507.
15. London GM, Marchais SJ, Guerin AP, Metivier F, Adda H. Arterial structure and function in end-stage renal disease. Nephrol Dial Transplant 2002;17:1713-1724.
16. Marchais S, Guerin A, Safar M, London G. Arterial compliance in uraemia. J Hypertens Suppl 1989;7:S84-S85.
17. Ogawa O, Onuma T, Kubo S, Mitsuhashi N, Muramatsu C, Kawamori R. Brachial-ankle pulse wave velocity and symptomatic cerebral infarction in patients with type 2 diabetes: a cross-sectional study. Cardiovasc Diabetol 2003;2:10.
18. Hatsuda S, Shoji T, Shinohara K, et al. Regional arterial stiffness associated with ischemic heart disease in type 2 diabetes mellitus. J Atheroscler Thromb 2006;13:114-121.
19. Cheng IK, Lu HB, Chan CY, et al. The requirement of low calcium dialysate in patients on continuous ambulatory peritoneal dialysis receiving calcium carbonate as a phosphate binder. Clin Nephrol 1993;40:100-105.
20. Lezaic V, Pejanovic S, Kostic S, et al. Effects of lowering dialysate calcium concentration on mineral metabolism and parathyroid hormone secretion: a multicentric study. Ther Apher Dial 2007;11:121-130.
21. Argiles A, Kerr PG, Canaud B, Flavier JL, Mion C. Calcium kinetics and the long-term effects of lowering dialysate calcium concentration. Kidney Int 1993;43:630-640.
22. Sage AP, Tintut Y, Demer LL. Regulatory mechanisms in vascular calcification. Nat Rev Cardiol 2010;7:528-536.
23. Lebreton JP, Joisel F, Raoult JP, Lannuzel B, Rogez JP, Humbert G. Serum concentration of human alpha 2 HS glycoprotein during the inflammatory process: evidence that alpha 2 HS glycoprotein is a negative acute-phase reactant. J Clin Invest 1979;64:1118-1129.
24. Shroff RC, Shah V, Hiorns MP, et al. The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis. Nephrol Dial Transplant 2008;23:3263-3271.
25. Stenvinkel P, Wang K, Qureshi AR, et al. Low fetuin-A levels are associated with cardiovascular death: impact of variations in the gene encoding fetuin. Kidney Int 2005;67:2383-2392.
26. Mori K, Emoto M, Araki T, et al. Association of serum fetuin-A with carotid arterial stiffness. Clin Endocrinol (Oxf) 2007;66:246-250.
27. Ketteler M, Bongartz P, Westenfeld R, et al. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet 2003;361:827-833.