메뉴 건너뛰기




Volumn 51, Issue 6, 2011, Pages 442-453

The novel virulence-related gene stp of Streptococcus suis serotype 9 strain contributes to a significant reduction in mouse mortality

Author keywords

Serine threonine protein phosphatase; Streptococcus suis serotype 9; Suppression subtractive hybridization; Virulence

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIABILITY; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BACTERIUM ISOLATION; BACTERIUM MUTANT; CELL ADHESION; CELL SURVIVAL; CONTROLLED STUDY; EXPERIMENTAL PIG; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC CODE; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; LD 50; MICROMORPHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SERINE THREONINE PROTEIN PHOSPHATASE GENE; SEROTYPE; STREPTOCOCCUS SUIS; SUPPRESSION SUBTRACTIVE HYBRIDIZATION; WILD TYPE;

EID: 80054834563     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2011.08.002     Document Type: Article
Times cited : (28)

References (43)
  • 1
    • 0034307834 scopus 로고    scopus 로고
    • The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions
    • Gottschalk M., Segura M. The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions. Veterinary Microbiology 2000 Oct 1, 76(3):259-272.
    • (2000) Veterinary Microbiology , vol.76 , Issue.3 , pp. 259-272
    • Gottschalk, M.1    Segura, M.2
  • 2
    • 15744401405 scopus 로고    scopus 로고
    • Biochemical analysis, cpn60 and 16S rDNA sequence data indicate that Streptococcus suis serotypes 32 and 34, isolated from pigs, are Streptococcus orisratti
    • Hill J.E., Gottschalk M., Brousseau R., Harel J., Hemmingsen S.M., Goh S.H. Biochemical analysis, cpn60 and 16S rDNA sequence data indicate that Streptococcus suis serotypes 32 and 34, isolated from pigs, are Streptococcus orisratti. Veterinary Microbiology 2005 Apr 25, 107(1-2):63-69.
    • (2005) Veterinary Microbiology , vol.107 , Issue.1-2 , pp. 63-69
    • Hill, J.E.1    Gottschalk, M.2    Brousseau, R.3    Harel, J.4    Hemmingsen, S.M.5    Goh, S.H.6
  • 3
    • 0035129356 scopus 로고    scopus 로고
    • Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits
    • Allgaier A., Goethe R., Wisselink H.J., Smith H.E., Valentin-Weigand P. Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits. Journal of Clinical Microbiology 2001 Feb, 39(2):445-453.
    • (2001) Journal of Clinical Microbiology , vol.39 , Issue.2 , pp. 445-453
    • Allgaier, A.1    Goethe, R.2    Wisselink, H.J.3    Smith, H.E.4    Valentin-Weigand, P.5
  • 4
    • 0034213785 scopus 로고    scopus 로고
    • Distribution of capsular types and production of muramidase-released protein (MRP) and extracellular factor (EF) of Streptococcus suis strains isolated from diseased pigs in seven European countries
    • Wisselink H.J., Smith H.E., Stockhofe-Zurwieden N., Peperkamp K., Vecht U. Distribution of capsular types and production of muramidase-released protein (MRP) and extracellular factor (EF) of Streptococcus suis strains isolated from diseased pigs in seven European countries. Veterinary Microbiology 2000 Jun 1, 74(3):237-248.
    • (2000) Veterinary Microbiology , vol.74 , Issue.3 , pp. 237-248
    • Wisselink, H.J.1    Smith, H.E.2    Stockhofe-Zurwieden, N.3    Peperkamp, K.4    Vecht, U.5
  • 5
    • 43349107182 scopus 로고    scopus 로고
    • Pathogenic characteristics of Streptococcus suis type 2 and type 9 isolated from Guangdong province
    • Yu W.L.L.C., Wang G.P., Lu C.P. Pathogenic characteristics of Streptococcus suis type 2 and type 9 isolated from Guangdong province. Veterinary Science in China 2007, 37(08):650-654.
    • (2007) Veterinary Science in China , vol.37 , Issue.8 , pp. 650-654
    • Yu, W.L.L.C.1    Wang, G.P.2    Lu, C.P.3
  • 6
    • 43349095352 scopus 로고    scopus 로고
    • Distributional characteristics of virulence-associated gene of Streptococcus suis strains isolated from China
    • Zhao R.S.J., Lu C.P. Distributional characteristics of virulence-associated gene of Streptococcus suis strains isolated from China. Journal of Shanghai Jiaotong University (Agricultural Science) 2006, 24:495-498.
    • (2006) Journal of Shanghai Jiaotong University (Agricultural Science) , vol.24 , pp. 495-498
    • Zhao, R.S.J.1    Lu, C.P.2
  • 7
    • 43349083190 scopus 로고    scopus 로고
    • Multiplex PCR assay for the detection of serotype 2 and 9 of Streptococcus suis
    • Liu J.F.S., Yin T.Y., Sun Y., Guo X.J., Zhu L. Multiplex PCR assay for the detection of serotype 2 and 9 of Streptococcus suis. Chinese Journal of Zoonoses 2005, 21:510-514.
    • (2005) Chinese Journal of Zoonoses , vol.21 , pp. 510-514
    • Liu, J.F.S.1    Yin, T.Y.2    Sun, Y.3    Guo, X.J.4    Zhu, L.5
  • 8
    • 0026725379 scopus 로고
    • Cloning and nucleotide sequence of the gene encoding the 136-kilodalton surface protein (muramidase-released protein) of Streptococcus suis type 2
    • Smith H.E., Vecht U., Gielkens A.L., Smits M.A. Cloning and nucleotide sequence of the gene encoding the 136-kilodalton surface protein (muramidase-released protein) of Streptococcus suis type 2. Infection and Immunity 1992 Jun, 60(6):2361-2367.
    • (1992) Infection and Immunity , vol.60 , Issue.6 , pp. 2361-2367
    • Smith, H.E.1    Vecht, U.2    Gielkens, A.L.3    Smits, M.A.4
  • 9
    • 0025827206 scopus 로고
    • Identification of two proteins associated with virulence of Streptococcus suis type 2
    • Vecht U., Wisselink H.J., Jellema M.L., Smith H.E. Identification of two proteins associated with virulence of Streptococcus suis type 2. Infection and Immunity 1991 Sep, 59(9):3156-3162.
    • (1991) Infection and Immunity , vol.59 , Issue.9 , pp. 3156-3162
    • Vecht, U.1    Wisselink, H.J.2    Jellema, M.L.3    Smith, H.E.4
  • 10
    • 0036180962 scopus 로고    scopus 로고
    • Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2
    • de Greeff A., Buys H., Verhaar R., Dijkstra J., van Alphen L., Smith H.E. Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2. Infection and Immunity 2002 Mar, 70(3):1319-1325.
    • (2002) Infection and Immunity , vol.70 , Issue.3 , pp. 1319-1325
    • de Greeff, A.1    Buys, H.2    Verhaar, R.3    Dijkstra, J.4    van Alphen, L.5    Smith, H.E.6
  • 11
    • 0028231216 scopus 로고
    • Identification, purification, and characterization of a thiol-activated hemolysin (suilysin) of Streptococcus suis
    • Jacobs A.A., Loeffen P.L., van den Berg A.J., Storm P.K. Identification, purification, and characterization of a thiol-activated hemolysin (suilysin) of Streptococcus suis. Infection and Immunity 1994 May, 62(5):1742-1748.
    • (1994) Infection and Immunity , vol.62 , Issue.5 , pp. 1742-1748
    • Jacobs, A.A.1    Loeffen, P.L.2    van den Berg, A.J.3    Storm, P.K.4
  • 12
    • 80054842218 scopus 로고    scopus 로고
    • LC-p Detection of the virulence2 associated genes of Streptococcus suis type 9 isolates in China and their protective efficacy in mice
    • Xiu Fu-xiao, LC-p Detection of the virulence2 associated genes of Streptococcus suis type 9 isolates in China and their protective efficacy in mice. Chinese Veterinary Science 2008, 38(02):97-100.
    • (2008) Chinese Veterinary Science , vol.38 , Issue.2 , pp. 97-100
    • Xiu, F.-X.1
  • 13
    • 48749096247 scopus 로고    scopus 로고
    • Comparative proteome analysis of secreted proteins of Streptococcus suis serotype 9 isolates from diseased and healthy pigs
    • Wu Z., Zhang W., Lu C. Comparative proteome analysis of secreted proteins of Streptococcus suis serotype 9 isolates from diseased and healthy pigs. Microbial Pathogenesis 2008 Sep, 45(3):159-166.
    • (2008) Microbial Pathogenesis , vol.45 , Issue.3 , pp. 159-166
    • Wu, Z.1    Zhang, W.2    Lu, C.3
  • 14
    • 17444450836 scopus 로고    scopus 로고
    • Identification and localization of differences between Escherichia coli and Salmonella typhimurium genomes by suppressive subtractive hybridization
    • Bogush M.L., Velikodvorskaya T.V., Lebedev Y.B., Nikolaev L.G., Lukyanov S.A., Fradkov A.F., et al. Identification and localization of differences between Escherichia coli and Salmonella typhimurium genomes by suppressive subtractive hybridization. Molecular and General Genetics 1999 Dec, 262(4-5):721-729.
    • (1999) Molecular and General Genetics , vol.262 , Issue.4-5 , pp. 721-729
    • Bogush, M.L.1    Velikodvorskaya, T.V.2    Lebedev, Y.B.3    Nikolaev, L.G.4    Lukyanov, S.A.5    Fradkov, A.F.6
  • 15
    • 0037317973 scopus 로고    scopus 로고
    • Genetic differences between two strains of Xylella fastidiosa revealed by suppression subtractive hybridization
    • Harakava R., Gabriel D.W. Genetic differences between two strains of Xylella fastidiosa revealed by suppression subtractive hybridization. Applied and Environmental Microbiology 2003 Feb, 69(2):1315-1319.
    • (2003) Applied and Environmental Microbiology , vol.69 , Issue.2 , pp. 1315-1319
    • Harakava, R.1    Gabriel, D.W.2
  • 16
  • 17
    • 10144255829 scopus 로고    scopus 로고
    • Opposing pairs of serine protein kinases and phosphatases transmit signals of environmental stress to activate a bacterial transcription factor
    • Yang X., Kang C.M., Brody M.S., Price C.W. Opposing pairs of serine protein kinases and phosphatases transmit signals of environmental stress to activate a bacterial transcription factor. Genes & Development 1996 Sep 15, 10(18):2265-2275.
    • (1996) Genes & Development , vol.10 , Issue.18 , pp. 2265-2275
    • Yang, X.1    Kang, C.M.2    Brody, M.S.3    Price, C.W.4
  • 18
    • 0031014176 scopus 로고    scopus 로고
    • Structural relationship between a bacterial developmental protein and eukaryotic PP2C protein phosphatases
    • Adler E., Donella-Deana A., Arigoni F., Pinna L.A., Stragler P. Structural relationship between a bacterial developmental protein and eukaryotic PP2C protein phosphatases. Molecular Microbiology 1997 Jan, 23(1):57-62.
    • (1997) Molecular Microbiology , vol.23 , Issue.1 , pp. 57-62
    • Adler, E.1    Donella-Deana, A.2    Arigoni, F.3    Pinna, L.A.4    Stragler, P.5
  • 19
    • 63149156264 scopus 로고    scopus 로고
    • Modulation of cell wall structure and antimicrobial susceptibility by a Staphylococcus aureus eukaryote-like serine/threonine kinase and phosphatase
    • Beltramini A.M., Mukhopadhyay C.D., Pancholi V. Modulation of cell wall structure and antimicrobial susceptibility by a Staphylococcus aureus eukaryote-like serine/threonine kinase and phosphatase. Infection and Immunity 2009 Apr, 77(4):1406-1416.
    • (2009) Infection and Immunity , vol.77 , Issue.4 , pp. 1406-1416
    • Beltramini, A.M.1    Mukhopadhyay, C.D.2    Pancholi, V.3
  • 20
    • 1842431057 scopus 로고    scopus 로고
    • Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae
    • Echenique J., Kadioglu A., Romao S., Andrew P.W., Trombe M.C. Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae. Infection and Immunity 2004 Apr, 72(4):2434-2437.
    • (2004) Infection and Immunity , vol.72 , Issue.4 , pp. 2434-2437
    • Echenique, J.1    Kadioglu, A.2    Romao, S.3    Andrew, P.W.4    Trombe, M.C.5
  • 21
    • 0032431404 scopus 로고    scopus 로고
    • A novel serine/threonine protein kinase homologue of Pseudomonas aeruginosa is specifically inducible within the host infection site and is required for full virulence in neutropenic mice
    • Wang J., Li C., Yang H., Mushegian A., Jin S. A novel serine/threonine protein kinase homologue of Pseudomonas aeruginosa is specifically inducible within the host infection site and is required for full virulence in neutropenic mice. Journal of Bacteriology 1998 Dec, 180(24):6764-6768.
    • (1998) Journal of Bacteriology , vol.180 , Issue.24 , pp. 6764-6768
    • Wang, J.1    Li, C.2    Yang, H.3    Mushegian, A.4    Jin, S.5
  • 22
    • 0037853258 scopus 로고    scopus 로고
    • A eukaryotic type serine/threonine kinase and phosphatase in Streptococcus agalactiae reversibly phosphorylate an inorganic pyrophosphatase and affect growth, cell segregation, and virulence
    • Rajagopal L., Clancy A., Rubens C.E. A eukaryotic type serine/threonine kinase and phosphatase in Streptococcus agalactiae reversibly phosphorylate an inorganic pyrophosphatase and affect growth, cell segregation, and virulence. The Journal of Biological Chemistry 2003 Apr 18, 278(16):14429-14441.
    • (2003) The Journal of Biological Chemistry , vol.278 , Issue.16 , pp. 14429-14441
    • Rajagopal, L.1    Clancy, A.2    Rubens, C.E.3
  • 23
    • 19944374470 scopus 로고    scopus 로고
    • Regulation of purine biosynthesis by a eukaryotic-type kinase in Streptococcus agalactiae
    • Rajagopal L., Vo A., Silvestroni A., Rubens C.E. Regulation of purine biosynthesis by a eukaryotic-type kinase in Streptococcus agalactiae. Molecular Microbiology 2005 Jun, 56(5):1329-1346.
    • (2005) Molecular Microbiology , vol.56 , Issue.5 , pp. 1329-1346
    • Rajagopal, L.1    Vo, A.2    Silvestroni, A.3    Rubens, C.E.4
  • 24
    • 33750492300 scopus 로고    scopus 로고
    • Regulation of cytotoxin expression by converging eukaryotic-type and two-component signalling mechanisms in Streptococcus agalactiae
    • Rajagopal L., Vo A., Silvestroni A., Rubens C.E. Regulation of cytotoxin expression by converging eukaryotic-type and two-component signalling mechanisms in Streptococcus agalactiae. Molecular Microbiology 2006 Nov, 62(4):941-957.
    • (2006) Molecular Microbiology , vol.62 , Issue.4 , pp. 941-957
    • Rajagopal, L.1    Vo, A.2    Silvestroni, A.3    Rubens, C.E.4
  • 26
    • 0034781075 scopus 로고    scopus 로고
    • Thermosensitive suicide vectors for gene replacement in Streptococcus suis
    • Takamatsu D., Osaki M., Sekizaki T. Thermosensitive suicide vectors for gene replacement in Streptococcus suis. Plasmid 2001 Sep, 46(2):140-148.
    • (2001) Plasmid , vol.46 , Issue.2 , pp. 140-148
    • Takamatsu, D.1    Osaki, M.2    Sekizaki, T.3
  • 27
    • 0035099359 scopus 로고    scopus 로고
    • Construction and characterization of Streptococcus suis-Escherichia coli shuttle cloning vectors
    • Takamatsu D., Osaki M., Sekizaki T. Construction and characterization of Streptococcus suis-Escherichia coli shuttle cloning vectors. Plasmid 2001 Mar, 45(2):101-113.
    • (2001) Plasmid , vol.45 , Issue.2 , pp. 101-113
    • Takamatsu, D.1    Osaki, M.2    Sekizaki, T.3
  • 28
    • 33645054791 scopus 로고    scopus 로고
    • Identification and biochemical characterization of a eukaryotic-type serine/threonine kinase and its cognate phosphatase in Streptococcus pyogenes: their biological functions and substrate identification
    • Jin H., Pancholi V. Identification and biochemical characterization of a eukaryotic-type serine/threonine kinase and its cognate phosphatase in Streptococcus pyogenes: their biological functions and substrate identification. Journal of Molecular Biology 2006 Apr 14, 357(5):1351-1372.
    • (2006) Journal of Molecular Biology , vol.357 , Issue.5 , pp. 1351-1372
    • Jin, H.1    Pancholi, V.2
  • 29
    • 1342323773 scopus 로고    scopus 로고
    • Invasion of porcine brain microvascular endothelial cells by Streptococcus suis serotype 2
    • Vanier G., Segura M., Friedl P., Lacouture S., Gottschalk M. Invasion of porcine brain microvascular endothelial cells by Streptococcus suis serotype 2. Infection and Immunity 2004 Mar, 72(3):1441-1449.
    • (2004) Infection and Immunity , vol.72 , Issue.3 , pp. 1441-1449
    • Vanier, G.1    Segura, M.2    Friedl, P.3    Lacouture, S.4    Gottschalk, M.5
  • 33
    • 34548619488 scopus 로고    scopus 로고
    • Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection
    • Dominguez-Punaro M.C., Segura M., Plante M.M., Lacouture S., Rivest S., Gottschalk M. Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection. Journal of Immunology 2007 Aug 1, 179(3):1842-1854.
    • (2007) Journal of Immunology , vol.179 , Issue.3 , pp. 1842-1854
    • Dominguez-Punaro, M.C.1    Segura, M.2    Plante, M.M.3    Lacouture, S.4    Rivest, S.5    Gottschalk, M.6
  • 34
    • 33745158157 scopus 로고
    • A simple method of estimating fifty per cent endpoints
    • Reed L.J. A simple method of estimating fifty per cent endpoints. American Journal of Epidemiology 1938, 27(3):493.
    • (1938) American Journal of Epidemiology , vol.27 , Issue.3 , pp. 493
    • Reed, L.J.1
  • 35
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • San Diego, Calif
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001 Dec, 25(4):402-408. San Diego, Calif.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 36
    • 77950594841 scopus 로고    scopus 로고
    • Immunoprotective activities of a Streptococcus suis pilus subunit in murine models of infection
    • Garibaldi M., Rodriguez-Ortega M.J., Mandanici F., Cardaci A., Midiri A., Papasergi S., et al. Immunoprotective activities of a Streptococcus suis pilus subunit in murine models of infection. Vaccine 2010 Apr 30, 28(20):3609-3616.
    • (2010) Vaccine , vol.28 , Issue.20 , pp. 3609-3616
    • Garibaldi, M.1    Rodriguez-Ortega, M.J.2    Mandanici, F.3    Cardaci, A.4    Midiri, A.5    Papasergi, S.6
  • 37
    • 0025790172 scopus 로고
    • A gene encoding a protein serine/threonine kinase is required for normal development of M. xanthus, a gram-negative bacterium
    • Munoz-Dorado J., Inouye S., Inouye M. A gene encoding a protein serine/threonine kinase is required for normal development of M. xanthus, a gram-negative bacterium. Cell 1991 Nov 29, 67(5):995-1006.
    • (1991) Cell , vol.67 , Issue.5 , pp. 995-1006
    • Munoz-Dorado, J.1    Inouye, S.2    Inouye, M.3
  • 39
    • 0033801870 scopus 로고    scopus 로고
    • Characterization of PrpC from Bacillus subtilis, a member of the PPM phosphatase family
    • Obuchowski M., Madec E., Delattre D., Boel G., Iwanicki A., Foulger D., et al. Characterization of PrpC from Bacillus subtilis, a member of the PPM phosphatase family. Journal of Bacteriology 2000 Oct, 182(19):5634-5638.
    • (2000) Journal of Bacteriology , vol.182 , Issue.19 , pp. 5634-5638
    • Obuchowski, M.1    Madec, E.2    Delattre, D.3    Boel, G.4    Iwanicki, A.5    Foulger, D.6
  • 40
    • 0036428610 scopus 로고    scopus 로고
    • Characterization of a membrane-linked Ser/Thr protein kinase in Bacillus subtilis, implicated in developmental processes
    • Madec E., Laszkiewicz A., Iwanicki A., Obuchowski M., Seror S. Characterization of a membrane-linked Ser/Thr protein kinase in Bacillus subtilis, implicated in developmental processes. Molecular Microbiology 2002 Oct, 46(2):571-586.
    • (2002) Molecular Microbiology , vol.46 , Issue.2 , pp. 571-586
    • Madec, E.1    Laszkiewicz, A.2    Iwanicki, A.3    Obuchowski, M.4    Seror, S.5
  • 41
    • 14644398001 scopus 로고    scopus 로고
    • Characterization of a eukaryotic type serine/threonine protein kinase and protein phosphatase of Streptococcus pneumoniae and identification of kinase substrates
    • Novakova L., Saskova L., Pallova P., Janecek J., Novotna J., Ulrych A., et al. Characterization of a eukaryotic type serine/threonine protein kinase and protein phosphatase of Streptococcus pneumoniae and identification of kinase substrates. The FEBS Journal 2005 Mar, 272(5):1243-1254.
    • (2005) The FEBS Journal , vol.272 , Issue.5 , pp. 1243-1254
    • Novakova, L.1    Saskova, L.2    Pallova, P.3    Janecek, J.4    Novotna, J.5    Ulrych, A.6
  • 42
    • 0035099328 scopus 로고    scopus 로고
    • Cloning and characterization of the gene encoding the glutamate dehydrogenase of Streptococcus suis serotype 2
    • Okwumabua O., Persaud J.S., Reddy P.G. Cloning and characterization of the gene encoding the glutamate dehydrogenase of Streptococcus suis serotype 2. Clinical and Diagnostic Laboratory Immunology 2001 Mar, 8(2):251-257.
    • (2001) Clinical and Diagnostic Laboratory Immunology , vol.8 , Issue.2 , pp. 251-257
    • Okwumabua, O.1    Persaud, J.S.2    Reddy, P.G.3
  • 43
    • 0033870279 scopus 로고    scopus 로고
    • Interactions between Streptococcus suis serotype 2 and different epithelial cell lines
    • Lalonde M., Segura M., Lacouture S., Gottschalk M. Interactions between Streptococcus suis serotype 2 and different epithelial cell lines. Microbiology (Reading, England) 2000 Aug, 146(Pt 8):1913-1921.
    • (2000) Microbiology (Reading, England) , vol.146 , Issue.PART 8 , pp. 1913-1921
    • Lalonde, M.1    Segura, M.2    Lacouture, S.3    Gottschalk, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.