ZLJ-6, a novel COX/5-LOX inhibitor, attenuates TNF-α-induced endothelial E-selectin, ICAM-1 and VCAM-1 expression and monocyte–endothelial interactions via a COX/5-LOX-independent mechanism

Vascular Pharmacology

Volumn 55, Issue 5-6, 2011, Pages 135-142

  Chen, Li ^a   Zhao, Qian ^a   Wang, Xu Liang ^a   You, Ran ^a   Zhang, Yi Hua ^a   Ji, Hui ^a   Lai, Yi Sheng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti inflammation; Cell adhesion; COX 5 LOX inhibitor; NF B; ZLJ 6

Indexed keywords

ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; CELECOXIB; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; I KAPPA B; I KAPPA B KINASE BETA; IMIDAZOLE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LIPOXYGENASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN SYNTHASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ZILEUTON; ZLJ 6; 1 METHYL 1,5 DIHYDRO 2 AMINO 5 (4 (MESYL)BENZYLIDENE) 4H IMIDAZOLE 4 ONE; 1-METHYL-1,5-DIHYDRO-2-AMINO-5-(4-(MESYL)BENZYLIDENE)-4H-IMIDAZOLE-4-ONE; CELL ADHESION MOLECULE; ICAM1 PROTEIN, HUMAN; NONSTEROID ANTIINFLAMMATORY AGENT; SELE PROTEIN, HUMAN; SULFONE; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL INTERACTION; CELL PROLIFERATION; CELL VIABILITY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DRUG CYTOTOXICITY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC50; MONOCYTE; MTT ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; METABOLISM; PROTEIN TRANSPORT; VASCULAR ENDOTHELIUM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 5-LIPOXYGENASE; CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CELLS, CULTURED; CYCLOOXYGENASE INHIBITORS; E-SELECTIN; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMIDAZOLES; INTERCELLULAR ADHESION MOLECULE-1; LIPOXYGENASE INHIBITORS; MONOCYTES; NF-KAPPA B; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SULFONES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 80054834372     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2011.07.003     Document Type: Article

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