Use of opioids or benzodiazepines and risk of pneumonia in older adults: A population-based case-control study

Journal of the American Geriatrics Society

Volumn 59, Issue 10, 2011, Pages 1899-1907

  Dublin, Sascha ^a,b   Walker, Rod L ^a   Jackson, Michael L ^a   Nelson, Jennifer C ^a,b   Weiss, Noel S ^b   Von Korff, Michael ^a,c   Jackson, Lisa A ^a,b  

^a GROUP HEALTH RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

adverse drug effects; benzodiazepines; epidemiology; opioids; pneumonia

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CODEINE; DEXTROPROPOXYPHENE; FENTANYL; HYDROCODONE; HYDROMORPHONE; LEVORPHANOL; METHADONE; MORPHINE; OPIATE; OPIATE DERIVATIVE; OXYCODONE; PETHIDINE; TRAMADOL;

AGED; ARTICLE; CASE CONTROL STUDY; COMMUNITY ACQUIRED PNEUMONIA; COMORBIDITY; CONTROLLED STUDY; DRUG USE; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RISK; INTEGRATED HEALTH CARE SYSTEM; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; POPULATION RESEARCH; PRESCRIPTION; RISK ASSESSMENT;

AGED; AGED, 80 AND OVER; ANALGESICS, OPIOID; BENZODIAZEPINES; CASE-CONTROL STUDIES; COMMUNITY-ACQUIRED INFECTIONS; COMORBIDITY; CROSS-SECTIONAL STUDIES; DRUG THERAPY, COMBINATION; DRUG UTILIZATION REVIEW; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; IMMUNOCOMPETENCE; INFLUENZA, HUMAN; MALE; ODDS RATIO; PNEUMONIA, VIRAL; RISK; UNITED STATES;

EID: 80054817161     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2011.03586.x     Document Type: Article

References (36)

1. Williams RE, Sampson TJ, Kalilani L, et al. Epidemiology of opioid pharmacy claims in the United States. J Opioid Manag 2008; 4: 145-152.
2. Boudreau D, Von Korff M, Rutter CM, et al. Trends in long-term opioid therapy for chronic non-cancer pain. Pharmacoepidemiol Drug Saf 2009; 18: 1166-1175.
3. American Geriatrics Society Panel on the Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. Pain Med 2009; 10: 1062-1083.
4. Gleason PP, Schulz R, Smith NL, et al. Correlates and prevalence of benzodiazepine use in community-dwelling elderly. J Gen Intern Med 1998; 13: 243-250.
5. Huxley EJ, Viroslav J, Gray WR, et al. Pharyngeal aspiration in normal adults and patients with depressed consciousness. Am J Med 1978; 64: 564-568.
6. Shavit Y, Ben-Eliyahu S, Zeidel A, et al. Effects of fentanyl on natural killer cell activity and on resistance to tumor metastasis in rats. Dose and timing study. Neuroimmunomodulation 2004; 11: 255-260.
7. Beilin B, Martin FC, Shavit Y, et al. Suppression of natural killer cell activity by high-dose narcotic anesthesia in rats. Brain Behav Immun 1989; 3: 129-137.
8. Shavit Y, Terman GW, Lewis JW, et al. Effects of footshock stress and morphine on natural killer lymphocytes in rats: Studies of tolerance and cross-tolerance. Brain Res 1986; 372: 382-385.
9. House RV, Thomas PT, Bhargava HN,. In vitro evaluation of fentanyl and meperidine for immunomodulatory activity. Immunol Lett 1995; 46: 117-124.
10. Beilin B, Shavit Y, Hart J, et al. Effects of anesthesia based on large versus small doses of fentanyl on natural killer cell cytotoxicity in the perioperative period. Anesth Analg 1996; 82: 492-497.
11. Sacerdote P, Manfredi B, Mantegazza P, et al. Antinociceptive and immunosuppressive effects of opiate drugs: A structure-related activity study. Br J Pharmacol 1997; 121: 834-840.
12. Wang J, Barke RA, Charboneau R, et al. Morphine impairs host innate immune response and increases susceptibility to Streptococcus pneumoniae lung infection. J Immunol 2005; 174: 426-434.
13. Malik AA, Radhakrishnan N, Reddy K, et al. Morphine-induced macrophage apoptosis modulates migration of macrophages: Use of in vitro model of urinary tract infection. J Endourol 2002; 16: 605-610.
14. Wang J, Barke RA, Charboneau R, et al. Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-kappa β signaling. J Immunol 2008; 180: 3594-3600.
15. Budd K,. Pain management: Is opioid immunosuppression a clinical problem? Biomed Pharmacother 2006; 60: 310-317.
16. Sacerdote P,. Opioids and the immune system. Palliat Med 2006; 20 (Suppl 1): s9-s15.
17. Sacerdote P, Bianchi M, Gaspani L, et al. The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients. Anesth Analg 2000; 90: 1411-1414.
18. Schwacha MG, McGwin G. Jr, Hutchinson CB, et al. The contribution of opiate analgesics to the development of infectious complications in burn patients. Am J Surg 2006; 192: 82-86.
19. Won A, Lapane KL, Vallow S, et al. Long-term effects of analgesics in a population of elderly nursing home residents with persistent nonmalignant pain. J Gerontol A Biol Sci Med Sci 2006; 61A: 165-169.
20. Almirall J, Bolibar I, Balanzo X, et al. Risk factors for community-acquired pneumonia in adults: A population-based case-control study. Eur Respir J 1999; 13: 349-355.
21. Almirall J, Bolibar I, Serra-Prat M, et al. New evidence of risk factors for community-acquired pneumonia: A population-based study. Eur Respir J 2008; 31: 1274-1284.
22. Vergis EN, Brennen C, Wagener M, et al. Pneumonia in long-term care: A prospective case-control study of risk factors and impact on survival. Arch Intern Med 2001; 161: 2378-2381.
23. Jackson ML, Nelson JC, Weiss NS, et al. Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: A population-based, nested case-control study. Lancet 2008; 372: 398-405.
24. Nelson JC, Jackson M, Yu O, et al. Impact of the introduction of pneumococcal conjugate vaccine on rates of community acquired pneumonia in children and adults. Vaccine 2008; 26: 4947-4954.
25. Saunders KW, Davis RL, Stergachis A,. Group health cooperative. In:, Strom BL, ed. Pharmacoepidemiology, 4th Ed. Chichester: John Wiley & Sons, 2005, pp 223-239.
26. Sacerdote P, Bianchi M, Manfredi B, et al. Effects of tramadol on immune responses and nociceptive thresholds in mice. Pain 1997; 72: 325-330.
27. Opium. Micromedex 10 Updated periodically. edn: Greenwood Village. Colo: Thomson Reuters (Healthcare) Inc., 2010.
28. Von Korff M, Saunders K, Thomas Ray G, et al. De facto long-term opioid therapy for noncancer pain. Clin J Pain 2008; 24: 521-527.
29. Gray SL, Eggen AE, Blough D, et al. Benzodiazepine use in older adults enrolled in a health maintenance organization. J Am Geriatr Soc 2003; 11: 568-576.
30. De Waal EJ, Van Der Laan JW, Van Loveren H,. Effects of prolonged exposure to morphine and methadone on in vivo parameters of immune function in rats. Toxicology 1998; 129: 201-210.
31. Singhal PC, Sharma P, Kapasi AA, et al. Morphine enhances macrophage apoptosis. J Immunol 1998; 160: 1886-1893.
32. Freier DO, Fuchs BA,. A mechanism of action for morphine-induced immunosuppression: Corticosterone mediates morphine-induced suppression of natural killer cell activity. J Pharmacol Exp Ther 1994; 270: 1127-1133.
33. Chapman CR, Lipschitz DL, Angst MS, et al. Opioid pharmacotherapy for chronic non-cancer pain in the United States: A research guideline for developing an evidence-base. J Pain 2010; 11: 807-829.
34. Jackson ML, Neuzil KM, Thompson WW, et al. The burden of community-acquired pneumonia in seniors: Results of a population-based study. Clin Infect Dis 2004; 39: 1642-1650.
35. Dublin S, Walker RL, Jackson ML, et al. Use of proton pump inhibitors and H2 blockers and risk of pneumonia in older adults: A population-based case-control study. Pharmacoepidemiol Drug Saf 2010; 19: 792-802.
36. Dublin S, Jackson ML, Nelson JC, et al. Statin use and risk of community acquired pneumonia in older people: Population based case-control study. BMJ 2009; 338: b2137.