Regulation of the HIV-1 promoter by HIF-1 and Vpr proteins

Virology Journal

Volumn 8, Issue , 2011, Pages

  Deshmane, Satish L ^a   Amini, Shohreh ^a,b   Sen, Satarupa ^a   Khalili, Kamel ^a   Sawaya, Bassel E ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Temple University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; TRANSCRIPTION FACTOR SP1; VPR PROTEIN; HIF1A PROTEIN, HUMAN; VPR PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

ARTICLE; CONCENTRATION (PARAMETERS); GC RICH SEQUENCE; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOCYTOCHEMISTRY; LONG TERMINAL REPEAT; MICROGLIA; NONHUMAN; PROMOTER REGION; REGULATORY MECHANISM; TRANSIENT TRANSFECTION; VIRUS TRANSCRIPTION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

GENE EXPRESSION REGULATION, VIRAL; HIV LONG TERMINAL REPEAT; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; VIRUS REPLICATION; VPR GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 80054794110     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-8-477     Document Type: Article

References (23)

1. HIV-1 Vpr: a closer look at the multifunctional protein from the structural perspective. Pandey RC, Datta D, Mukerjee R, Srinivasan A, Mahalingam S, Sawaya BE, Curr HIV Res 2009 7 114 128 10.2174/157016209787581508 19275580
2. Human immunodeficiency virus type 1 Vpr inhibits axonal outgrowth through induction of mitochondrial dysfunction. Kitayama H, Miura Y, Ando Y, Hoshino S, Ishizaka Y, Koyanagi Y, J Virol 2008 82 2528 2542 10.1128/JVI.02094-07 18094160 (Pubitemid 351293553)
3. Slipping through the door: HIV entry into the nucleus. Sherman MP, Greene WC, Microbes Infect 2002 4 67 73 10.1016/S1286-4579(01)01511-8 11825777 (Pubitemid 34127993)
4. Effect of HIV-1 Vpr on cell cycle regulators. Amini S, Khalili K, Sawaya BE, DNA Cell Biol 2004 23 249 260 10.1089/104454904773819833 15142382 (Pubitemid 38591236)
5. HIV-1 Vpr causes neuronal apoptosis and in vivo neurodegeneration. Jones GJ, Barsby NL, Cohen EA, Holden J, Harris K, Dickie P, Jhamandas J, Power C, J Neurosci 2007 27 3703 3711 10.1523/JNEUROSCI.5522-06.2007 17409234 (Pubitemid 46557688)
6. Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression. Deshmane SL, Mukerjee R, Fan S, Del Valle L, Michiels C, Sweet T, Rom I, Khalili K, Rappaport J, Amini S, Sawaya BE, J Biol Chem 2009 284 11364 11373 19204000
7. Mitochondrial reactive oxygen species are required for hypoxic HIF alpha stabilization. Simon MC, Adv Exp Med Biol 2006 588 165 170 10.1007/978-0-387- 34817-9-15 17089888
8. Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis. Kupershmidt L, Weinreb O, Amit T, Mandel S, Carri MT, Youdim MB, FASEB J 2009 23 3766 3779 10.1096/fj.09-130047 19638399
9. Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. Lee DW, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal MF, Ratan RR, Andersen JK, J Biol Chem 2009 284 29065 29076 10.1074/jbc.M109.000638 19679656
10. Contribution of hypoxia to Alzheimer's disease: is HIF-1alpha a mediator of neurodegeneration? Ogunshola OO, Antoniou X, Cell Mol Life Sci 2009 66 3555 3563 10.1007/s00018-009-0141-0 19763399
11. Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability. Schults MA, Timmermans L, Godschalk RW, Theys J, Wouters BG, van Schooten FJ, Chiu RK, J Biol Chem 2010 285 14558 14564 10.1074/jbc.M109.076323 20228066
12. The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy. DeClerck K, Elble RC, Front Biosci 2010 15 213 225 10.2741/3616 20036816
13. Purification and characterization of hypoxia-inducible factor 1. Wang GL, Semenza GL, J Biol Chem 1995 270 1230 1237 10.1074/jbc.270.3.1230 7836384
14. 2tension. Wang GL, Jiang BH, Rue EA, Semenza GL, Proc Natl Acad Sci USA 1995 92 5510 5514 10.1073/pnas.92.12.5510 7539918
15. Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE, Proc Natl Acad Sci USA 1991 88 5680 5684 10.1073/pnas.88.13.5680 2062846 (Pubitemid 21914809)
16. Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain. Maemura K, Hsieh CM, Jain MK, Fukumoto S, Layne MD, Liu Y, Kourembanas S, Yet SF, Perrella MA, Lee ME, J Biol Chem 1999 274 31565 31570 10.1074/jbc.274.44.31565 10531360 (Pubitemid 29508520)
17. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Carrero P, Okamoto K, Coumailleau P, O'Brien S, Tanaka H, Poellinger L, Mol Cell Biol 2000 20 402 415 10.1128/MCB.20.1.402-415.2000 10594042 (Pubitemid 30002581)
18. In vitro cultivation of human renal cell cancer. I. Establishment of cells in culture. Williams RD, Elliott AY, Stein N, Fraley EE, In Vitro 1976 12 623 627 10.1007/BF02797460 1010528 (Pubitemid 8048130)
19. Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Jones KA, Kadonaga JT, Luciw PA, Tjian R, Science 1986 232 755 759 10.1126/science.3008338 3008338 (Pubitemid 16078720)
20. Cooperative actions of HIV-1 Vpr and p53 modulate viral gene transcription. Sawaya BE, Khalili K, Mercer WE, Denisova L, Amini S, J Biol Chem 1998 273 20052 20057 10.1074/jbc.273.32.20052 9685344 (Pubitemid 28377557)
21. Antiviral roles of APOBEC proteins against HIV-1 and suppression by Vif. Romani B, Engelbrecht S, Glashoff RH, Arch Virol 2009 154 1579 1588 10.1007/s00705-009-0481-y 19669862
22. Interplay between HIV-1 Vpr and Sp1 modulates p21(WAF1) gene expression in human astrocytes. Amini S, Saunders M, Kelley K, Khalili K, Sawaya BE, J Biol Chem 2004 279 46046 46056 10.1074/jbc.M403792200 15302882 (Pubitemid 39491598)
23. Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genome. Sawaya BE, Khalili K, Gordon J, Taube R, Amini S, J Biol Chem 2000 275 35209 35214 10.1074/jbc.M005197200 10931842