Indolin-2-one p38α inhibitors III: Bioisosteric amide replacement

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 21, 2011, Pages 6253-6257

  Eastwood, Paul ^a   González, Jacob ^a   Gómez, Elena ^a   Caturla, Francisco ^a   Aguilar, Nuria ^a   Mir, Marta ^a   Aiguadé, Josep ^a   Matassa, Victor ^a   Balagué, Cristina ^a   Orellana, Adelina ^a   Domínguez, María ^a  

^a Ctra Laureà Miró 408 ^*  (Spain)

Author keywords

Bioisosterism; Indolin 2 ones; P38 Inhibitors; Structure based design

Indexed keywords

AMIDE; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; BIOSYNTHESIS; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG POTENCY; HUMAN; HYDROLYSIS; IN VIVO STUDY; INFLAMMATION; LIVER; NONHUMAN; RAT; STRUCTURE ANALYSIS;

RATTUS;

EID: 80054785360     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.006     Document Type: Article

References (12)

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12. The torsion angle between these two rings in the bound conformation of compound 1 is 71° as ascertained from the crystal structure (Ref. 1a).