α-synuclein promotes neuroprotection through NF-κB-mediated transcriptional regulation of protein kinase Cδ

Science Signaling

Volumn 4, Issue 195, 2011, Pages

  Aoki, Reina ^a   Li, Yun Rose ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE C DELTA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; BINDING SITE; CELLULAR DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; DOPAMINERGIC NERVE CELL; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; HISTONE ACETYLATION; HUMAN; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; NOTE; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ARTICLE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; PATHOLOGY; SUBSTANTIA NIGRA;

ALPHA-SYNUCLEIN; APOPTOSIS; DOPAMINERGIC NEURONS; GENE EXPRESSION REGULATION; HUMANS; MUTATION; NF-KAPPA B; PARKINSON DISEASE; PROTEIN KINASE C-DELTA; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA;

EID: 80054767289     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002425     Document Type: Note

References (14)

1. J. F. Morley, H. I. Hurtig, Current understanding and management of Parkinson disease: Five new things. Neurology 75 (suppl. 1), S9-S15 (2010).
2. J. Simón-Sánchez, C. Schulte, J. M. Bras, M. Sharma, J. R. Gibbs, D. Berg, C. Paisan-Ruiz, P. Lichtner, S. W. Scholz, D. G. Hernandez, R. Krüger, M. Federoff, C. Klein, A. Goate, J. Perlmutter, M. Bonin, M. A. Nalls, T. Illig, C. Gieger, H. Houlden, M. Steffens, M. S. Okun, B. A. Racette, M. R. Cookson, K. D. Foote, H. H. Fernandez, B. J. Traynor, S. Schreiber, S. Arepalli, R. Zonozi, K. Gwinn, M. van der Brug, G. Lopez, S. J. Chanock, A. Schatzkin, Y. Park, A. Hollenbeck, J. Gao, X. Huang, N. W. Wood, D. Lorenz, G. Deuschl, H. Chen, O. Riess, J. A. Hardy, A. B. Singleton, T. Gasser, Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet. 41, 1308-1312 (2009).
3. W. Satake, Y. Nakabayashi, I. Mizuta, Y. Hirota, C. Ito, M. Kubo, T. Kawaguchi, T. Tsunoda, M. Watanabe, A. Takeda, H. Tomiyama, K. Nakashima, K. Hasegawa, F. Obata, T. Yoshikawa, H. Kawakami, S. Sakoda, M. Yamamoto, N. Hattori, M. Murata, Y. Nakamura, T. Toda, Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat. Genet. 41, 1303-1307 (2009).
4. T. N. M. Alerte, A. A. Akinfolarin, E. E. Friedrich, S. A. Mader, C. S. Hong, R. G. Perez, α-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice. Neurosci. Lett. 435, 24-29 (2008).
5. V. Anantharam, M. Kitazawa, J. Wagner, S. Kaul, A. G. Kanthasamy, Caspase-3-dependent proteolytic cleavage of protein kinase Cδ is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J. Neurosci. 22, 1738-1751 (2002).
6. D. Zhang, V. Anantharam, A. Kanthasamy, A. G. Kanthasamy, Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease. J. Pharmacol. Exp. Ther. 322, 913-922 (2007).
7. A. Gupta, V. L. Dawson, T. M. Dawson, What causes cell death in Parkinson's disease? Ann. Neurol. 64 (suppl. 2), S3-S15 (2008).
8. S. Hwang, D. Kim, G. Choi, S. W. An, Y. K. Hong, Y. S. Suh, M. J. Lee, K. S. Cho, Parkin suppresses c-Jun N-terminal kinase-induced cell death via transcriptional regulation in Drosophila. Mol. Cells 29, 575-580 (2010).
9. Y. Yuan, J. Sun, M. Zhao, J. Hu, X. Wang, G. Du, N. H. Chen, Overexpression of α-synuclein down-regulates BDNF expression. Cell. Mol. Neurobiol. 30, 939-946 (2010).
10. H. Jin, A. Kanthasamy, A. Ghosh, Y. Yang, V. Anantharam, A. G. Kanthasamy, α-synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J. Neurosci. 31, 2035-2051 (2011).
11. S. Chandra, G. Gallardo, R. Fernández-Chacón, O. M. Schlüter, T. C. Südhof, α-synuclein cooperates with CSPα in preventing neurodegeneration. Cell 123, 383-396 (2005).
12. L. F. Chen, W. C. Greene, Shaping the nuclear action of NF-κB. Nat. Rev. Mol. Cell Biol. 5, 392-401 (2004).
13. H. Jin, A. Kanthasamy, V. Anantharam, A. Rana, A. G. Kanthasamy, Transcriptional regulation of pro-apoptotic protein kinase Cδ: Implications for oxidative stress-induced neuronal cell death. J. Biol. Chem. 286, 19840-19859 (2011).
14. Acknowledgments: We thank A. Gitler and T. Lamitina for their useful comments and suggestions as well as continued support and encouragement.