Design and synthesis of novel N-substituted-3-chloro-2- azetidinone derivatives as potential anticonvulsant agents

Medicinal Chemistry Research

Volumn 20, Issue 8, 2011, Pages 1357-1363

  Hasan, Hozaifa ^a   Akhter, Maymoona ^a   Akhter, Wasim ^a   Ali, Israr ^a   Zaheen, Mohd ^a   Ahsan, Iftikhar ^a   Mahmood, Danish ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Azetidinone; CNS depressant; MES; Neurotoxicity; PTZ

Indexed keywords

ALDEHYDE; ANTICONVULSIVE AGENT; AZETIDINONE DERIVATIVE; CARBAMAZEPINE; ISONIAZID; N [3 CHLORO 2 (PHENYL) 4 OXO AZETIDIN 1 YL]ISONICOTINAMIDE; PHENYTOIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; INFRARED RADIATION; MASS SPECTROMETRY; MOUSE; NEUROTOXICITY; NONHUMAN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 80054766182     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-010-9485-0     Document Type: Article

References (19)

1. Al-Soud YA, Al-Masoudi NA, Ferwanah A (2003) Synthesis and properties of new substituted 1,2,4-triazoles: Potential antitumor agents. Bioorg Med Chem 11(8):1701-1708 (Pubitemid 36349151)
2. Chernykh VP, Sidorenko OF (1981) Synthesis of ethyl N-[6- substituted benzo (tetrahydrobenzo)-2-thiazolyl] oxamate for hypoglycemic activity. Deposited Doc SPSTL 372 khp-D81:6 (Chem Abstr, 1982, 98:89233x
3. Costakes E, Tsatsas G (1978) Synthesis of 2-(alkylamino acyl imino)- 3-methyl benzothiazolines for local anaesthetic activity. Ann Pharm Fr 36(9-10):417-430 (Chem Abstr, 1979, 90:203935q
4. Deshmukh ARAS, Bhawal BM, Krishnaswami D, Govande VV, Shinkre BA, Jayanthi A (2004) Azetidin-2-ones, synthon for biologically important compounds. Curr Med Chem 11: 1889-1920 (Pubitemid 38821349)
5. El-Helby AGA, Wahab MHA (2003) Design and synthesis of some new derivatives of 3H-quinazolin-4-one with promising anticonvulsant activity. Acta Pharm 53:127-138 (Pubitemid 36850884)
6. Krall RL, Penry JK, White BG, Kupferbeng HJ, Swinyard EA (1978) Antiepileptic drug development: II. Anticonvulsant drug screening. Epilepsy 19:409-428 (Pubitemid 9016848)
7. Kupferberg HJ (1989) Antiepileptic drug development program: A cooperative effort of government and industry. Epilepsia 30(Suppl 1):S51-S56 (Pubitemid 19239013)
8. Lin Z, Kadaba PK (1997) Molecular targets for the rational design of antiepileptic drugs and related neuroprotective agents. Med Res Rev 17:537-572 (Pubitemid 27489491)
9. Loscher W (1998) New visions in the pharmacology of anticonvulsion. Eur J Pharmacol 342:1-13 (Pubitemid 28131339)
10. Patel KH, Mehta AG (2006) Synthesis of novel azetidinone and thiazolidinones derivatives and evaluation of their antimicrobial efficacy. E J Chem 3(11):103-109
11. Perucca E (1996) The new generation of antiepileptic drugs: Advantages and disadvantages. Br J Clin Pharmacol 42:531-543 (Pubitemid 26385257)
12. Porsolt RD, Anton G, Blanet N, Jalfer M (1978) Behavioural despair in rats: A new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379-391
13. Porter RJ, Cereghino JJ, Gladding GD, Hessie BJ, Kupferberg HJ, Scoville B, White B (1984) Antiepileptic drug development program. Cleveland Clin Q 51:293-305 (Pubitemid 14038030)
14. Russo F, Romeo G, Santagati NA, Caruso A, Cutuli V, Amore D (1994) Synthesis of new thienopyrimidobenzothiazoles and thienopyrimidobenzoxazoles with analgesic and anti-inflammatory properties. Eur J Med Chem 29:569-578 (Pubitemid 24266020)
15. Singh GS (2003) Recent progress in the synthesis and chemistry of azetidinones. Tetrahedron 59:7631-7649 (Pubitemid 37107451)
16. Singh GS (2004) Beta-lactams in the new millennium. Part-I: Monobactams and carbapenems. Mini Rev Med Chem 4(1): 69-92 (Pubitemid 38849367)
17. Sreenivasa RD, Jayachandran E, Sreenivasa GM, Shivakumar B (2005) Inhibition of albumin denaturation and anti-inflammatory activity of 2-[N-p-Tolyl sulphon hydrazino]-6-fluoro-7-substituted (1,3)benzothiazoles. Orient J Chem 21(1):113-116
18. Staudinger H (1907) Zur Kenntniss der Ketene. Diphenylketen. Justus Liebigs Ann Chem 356:51-123
19. Wasterlain C (1989) Epileptic seizures. In: Siegel G, Agranoff G, Albers RW, Mollinoff P (eds) Basic neurochemistry: Molecular, cellular and medical aspects, 4th edn. Raven, New York, pp 797-810