Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: Implications for the treatment of Parkinson's disease

Chemical Research in Toxicology

Volumn 24, Issue 10, 2011, Pages 1644-1652

  Sabens Liedhegner, Elizabeth A ^a   Steller, Kelly M ^a,b   Mieyal, John J ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 3; CEP 1347; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEVODOPA; MITOGEN ACTIVATED PROTEIN KINASE; MIXED LINEAGE KINASE; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; PARKINSON DISEASE; PROTEIN PHOSPHORYLATION;

ANTHRACENES; ANTIPARKINSON AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DOPAMINERGIC NEURONS; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEVODOPA; MAP KINASE KINASE KINASE 5; NF-KAPPA B; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARKINSON DISEASE; PYRIDINES;

EID: 80054764498     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200082h     Document Type: Article

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