Chromatin plasticity and the pathogenesis of Huntington disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 41, 2011, Pages 16867-16868

  Ehrlich, Michelle E ^a   Gandy, Sam ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HISTONE H2A; HISTONE H2A1; HISTONE H2AFY; UNCLASSIFIED DRUG;

CHROMATIN; DISEASE SEVERITY; DRUG TARGETING; GENETICS; GENOMICS; HISTOPATHOLOGY; HUMAN; HUNTINGTON CHOREA; MOLECULAR IMAGING; NEUROBIOLOGY; NONHUMAN; NOTE; PATHOGENESIS; PLASTICITY; PRIORITY JOURNAL;

ANIMALS; FEMALE; HISTONES; HUMANS; HUNTINGTON DISEASE; MALE;

EID: 80054763469     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113321108     Document Type: Note

References (16)

1. Hu Y, et al. (2011) Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse. Proc Natl Acad Sci USA 108:17141-17146.
2. Mueller SG, et al. (2005) Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimers Dement 1: 55-66. (Pubitemid 43348857)
3. Aizenstein HJ, et al. (2008) Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol 65:1509-1517.
4. Gandy S (2011) Perspective: Prevention is better than cure. Nature 475:S15.
5. Robinson S, Pool R, Giffin R (2008) Emerging Safety Science. Forum on Drug Discovery, Development, and Translation (National Academies Press, Washington, DC).
6. Kassubek J, et al. (2011) Fully automated atlas-based MR imaging volumetry in Huntington disease, compared with manual volumetry. AJNR Am J Neuroradiol 32:1328-1332.
7. Esmaeilzadeh M, Kullingsjö J, Ullman H, Varrone A, Tedroff J (2011) Regional cerebral glucose metabolism after pridopidine (ACR16) treatment in patients with Huntington disease. Clin Neuropharmacol 34:95-100.
8. Squitieri F, Esmaeilzadeh M, Ciarmiello A, Jankovic J (2011) Caudate glucose hypometabolism in a subject carrying an unstable allele of intermediate CAG(33) repeat length in the Huntington's disease gene. Mov Disord 26:925-927.
9. Gandy S (2005) The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. J Clin Invest 115:1121-1129.
10. Tanasijevic B, Rasmussen TP (2011) X chromosome inactivation and differentiation occur readily in ES cells doubly-deficient for macroH2A1 and macroH2A2. PLoS ONE 6:e21512.
11. Enokido Y, et al. (2010) Mutant huntingtin impairs Ku70-mediated DNA repair. J Cell Biol 189:425-443.
12. Gamble MJ, Kraus WL (2010) Multiple facets of the unique histone variant macroH2A: From genomics to cell biology. Cell Cycle 9:2568-2574.
13. Boulard M, et al. (2010) Histone variant macroH2A1 deletion in mice causes female-specific steatosis. Epigenetics Chromatin 3:8.
14. Valenza M, Cattaneo E (2011) Emerging roles for cholesterol in Huntington's disease. Trends Neurosci 34: 474-486.
15. Bhattacharyya NP, Banerjee M, Majumder P (2008) Huntington's disease: Roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription. FEBS J 275:4271-4279.
16. Wu LL, Zhou XF (2009) Huntingtin associated protein 1 and its functions. Cell Adh Migr 3:71-76.