The impact of high-dose statin therapy on transendothelial neutrophil migration and serum cholesterol levels in healthy male volunteers

European Journal of Clinical Pharmacology

Volumn 67, Issue 11, 2011, Pages 1103-1108

  Kinsella, Aisling ^a,b   Raza, Adnan ^a   Kennedy, Susan ^b   Fan, Yue ^b   Wood, Alfred E ^a   Watson, R W ^b  

^a MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Cardiothoracic surgery; Neutrophil migration; Statin therapy; Systemic inflammatory response syndrome; Therapeutic intervention

Indexed keywords

ATORVASTATIN; CHOLESTEROL; CREATINE KINASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ASSAY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG WITHDRAWAL; EX VIVO STUDY; HUMAN; HUMAN EXPERIMENT; IMMUNOMODULATION; IN VIVO STUDY; LEUKOCYTE COUNT; MALE; NEUTROPHIL CHEMOTAXIS; NORMAL HUMAN; PRIORITY JOURNAL; STIMULUS RESPONSE; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UNSPECIFIED SIDE EFFECT;

ADULT; ANTI-INFLAMMATORY AGENTS; CARDIOVASCULAR DISEASES; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; NEUTROPHILS; POSTOPERATIVE COMPLICATIONS; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION;

EID: 80054762022     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-011-1062-z     Document Type: Article

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