A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 22, 2011, Pages 6872-6875

  Fröhlich, Richard F G ^a,c   Fantur, Katrin ^b   Furneaux, Richard H ^a   Paschke, Eduard ^b   Stütz, Arnold E ^c   Wicki, Jacqueline ^d   Withers, Stephen G ^d   Wrodnigg, Tanja M ^c  

^a CALLAGHAN INNOVATION   (New Zealand)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

d Galactosidase inhibitor; Fluorescent probe; GM1 gangliosidosis; Iminoalditols; Pharmacological chaperone

Indexed keywords

BETA GALACTOSIDASE; CHAPERONE; GALACTITOL; IMINOSUGAR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; N (DANSYLAMINO)HEXYLAMINOCARBONYLPENTYL 1,5 DIDEOXY 1,5 IMINO DEXTRO GALACTITOL; TRACER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG ACTIVITY; DRUG DETERMINATION; ENZYME INHIBITION; FIBROBLAST; GM1 GANGLIOSIDOSIS; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

AGROBACTERIUM; BETA-GALACTOSIDASE; ESCHERICHIA COLI; FIBROBLASTS; FLUORESCENT DYES; GALACTITOL; GANGLIOSIDOSIS, GM1; HUMANS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MICROSCOPY, FLUORESCENCE; MUTATION;

EID: 80054760142     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.012     Document Type: Article

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