Cot-side electroencephalography monitoring is not clinically useful in the detection of mild neonatal hypoglycemia

Journal of Pediatrics

Volumn 159, Issue 5, 2011, Pages 755-760.e1

  Harris, Deborah L ^a,b   Weston, Philip J ^a   Williams, Christopher E ^b   Pleasants, Anthony B ^b   Battin, Malcolm R ^b,c   Spooner, Claire G ^d   Harding, Jane E ^b  

^a WAIKATO DISTRICT HEALTH BOARD   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c AUCKLAND CITY HOSPITAL   (New Zealand)

^d STARSHIP CHILDREN S HOSPITAL   (New Zealand)

Author keywords

aEEG; Amplitude integrated electroencephalograph; EEG; Electroencephalography; Neonatal intensive care unit; NICU

Indexed keywords

3 HYDROXYBUTYRIC ACID; GLUCOSE; GLYCEROL; LACTIC ACID;

ARTICLE; BIRTH WEIGHT; BLOOD GLUCOSE MONITORING; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; COT SIDE AMPLITUDE INTEGRATED ELECTROENCEPHALOGRAPHY; DIAGNOSTIC VALUE; ELECTROENCEPHALOGRAPHY; FEMALE; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; GLYCEROL BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INTERSTITIAL GLUCOSE MONITORING; LACTATE BLOOD LEVEL; MALE; NEWBORN; NEWBORN DISEASE; PATIENT MONITORING; PRIORITY JOURNAL; RISK FACTOR;

EID: 80054758184     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2011.04.026     Document Type: Article

References (38)

1. T.H. Koh, A. Aynsley-Green, M. Tarbit, and J.A. Eyre Neural dysfunction during hypoglycaemia Arch Dis Child 63 1988 1353 1358
2. A. Lucas, R. Morley, and T. Cole Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia BMJ 297 1988 1304 1308
3. W. Hay, T. Raju, R. Higgins, S. Kalhan, and S. Devaskar Knowledge gaps and research needs for understanding and treating neonatal hypoglycaemia: workshop report from Eunice Kennedy Shriver National Institute of Child Health and Human Development J Pediatr 155 2009 612 617
4. L. Hellstrom-Westas, I. Rosen, and N.W. Svenningsen Cerebral complications detected by EEG-monitoring during neonatal intensive care Acta Paediatr Scand 360 1989 83 86 (Pubitemid 20089958)
5. C.M. Burns, M.A. Rutherford, J.P. Boardman, and F.M. Cowan Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycaemia Pediatrics 122 2008 65 74
6. M. Koivisto, M. Blanco-Sequeiros, and U. Krause Neonatal symptomatic and asymptomatic hypoglycaemia: a follow up study of 151 children Dev Med Child Neurol 14 1972 603 614
7. R. Auer, Y. Olsson, and B. Siesjo Hypoglycemic brain injury in the rat: correlation of density of brain damage with the EEG isoelectric time: a quantitative study Diabetes 33 1984 1090 1098 (Pubitemid 15204588)
8. G. Tallroth, M. Lindgren, G. Stenberg, I. Rosen, and C.-D. Agardh Neurophysiological changes during insulin-induced hypoglycaemia and in the recovery period following glucose infusion in Type I (insulin-dependent) diabetes mellitus and in normal man Diabetologia 33 1990 319 323 (Pubitemid 20161888)
9. R.E. Spitzmiller, T. Phillips, J. Meinzen-Der, and S.B. Hoath Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full term infants with hypoxic-ischemic encephalopathy: a meta-analysis J Child Neurol 22 2007 1069 1078 (Pubitemid 47421538)
10. O. Pryds, G. Gresisen, and B. Friis-Hansen Compensatory increase of CBF in preterm infants during hypoglycaemia Acta Paediatr Scand 77 1988 632 637
11. E. Stenninger, E. Eriksson, A. Stigfur, J. Schollin, and J. Aman Monitoring of early postnatal glucose homeostasis and cerebral function in newborn infants of diabetic mothers. A pilot study Early Hum Dev 62 2001 23 32 (Pubitemid 32178135)
12. M. Bjorgaas, T. Sand, T. Vik, and R. Jorde Quantitative EEG during controlled hypoglycaemia in diabetic and non-diabetic children J Br Diabetic Assoc 15 1998 30 37 (Pubitemid 28113996)
13. A. Alkalay, L. Flores-Sarnat, H. Sarnat, F. Moser, and C. Simmons Brain imaging findings in neonatal hypoglycaemia: case report and review of 23 cases Clin Pediatr 44 2005 783 790 (Pubitemid 41779044)
14. J. Anderson, R. Milner, and S. Strich Effects of neonatal hypoglycaemia on the nervous system: a pathological study J Neurol Neurosurg Psychiatry 30 1967 295 310
15. D. Harris, M. Battin, C. Williams, P. Weston, and J. Harding Cot-side electro-encephalography and interstitial glucose monitoring during insulin-induced hypoglycaemia in newborn lambs Neonatology 95 2009 271 278
16. D. Harris, P. Weston, M. Battin, and J. Harding Continuous glucose monitoring in newborn babies at risk of neonatal hypoglycaemia J Pediatr 157 2010 198 202
17. J.M. Hawdon, M.P. Ward-Platt, and A. Aynsley-Green Patterns of metabolic adaption for preterm and term infants in the first neonatal week Arch Dis Child 67 1992 357 365
18. A.M. de L Costello, D.K. Par, D.S. Manandhar, S. Rajbhandari, J.M. Land, and N. Patel Neonatal hypoglycaemia in Nepal 2. Availability of alternative fuels Arch Dis Child Fetal Neonatal Ed 82 2005 F52 F58
19. J.M. Hawdon, and M.P. Ward-Platt Metabolic adaptation in small for gestational age infants Arch Dis Child 68 1993 262 268 (Pubitemid 23075786)
20. J.M. Hawdon, A. Weddell, A. Aynsley-Green, and M.P. Ward-Platt Hormonal and metabolic response to hypoglycaemia in small for gestational age infants Arch Dis Child 68 1993 269 273 (Pubitemid 23075787)
21. C.E. Williams, and P.D. Gluckman Real-time spectral intensity analysis of EEG on a common microcomputer J Neurosci Methods 32 1990 9 13 (Pubitemid 20111973)
22. P.S. Sebel, D.E. Maynard, E. Major, and M. Frank The cerebral function analysing monitor (CFAM) Br JAnaesth 55 1983 1265 1270
23. L. Hellstrom-Westas, I. Rosen, L. de Vries, and G. Gresisen Amplitude-integrated EEG classification and interpretation in preterm and term infants NeoReviews 7 2007 76 87
24. K. Thorngren-Jerneck, D. Ley, L. Hellstrom-Westas, E. Hernandez-Andrade, G. Lingman, and T. Ohlsson Reduced postnatal cerebral glucose metabolism measure by PET after asphyxia in near term fetal lambs J Neurosci Res 66 2001 844 850
25. R.N. Auer, and B.K. Siesjo Hypoglycaemia: brain neurochemistry and neuropathology Baillieres Clin Endocrinol Metab 7 1993 611 625 (Pubitemid 23243429)
26. A.H. Bell, B.G. McClure, P.J. McCullagh, and R.J. McClelland Spectral edge frequency of the EEG in healthy neonates and variation with behavioural state Neonatology 60 1991 60 69
27. A.H. Bell, B.G. McClure, P.J. McCullagh, and R.J. McClelland Variation in power spectral analysis of the EEG with gestational age J Clin Neurophysiol 8 1991 312 319
28. C. West, J.E. Harding, C. Williams, M. Gunning, and M. Battin Quantitative electroencephalographic patterns in normal preterm infants over the first week after birth Early Hum Dev 82 2006 43 51 (Pubitemid 43163039)
29. J. Bowen, M. Paradisis, and S. Dharmesh Decreased aEEG continuity and decreased baseline variability in the first 48 hours of life associated with poor short term outcome in neonates born before 29 weeks gestation Pediatr Res 67 2010 538 544
30. Platas II, M.T. Lluch, N.P. Alminana, A.M. Palomo, M.I. Sanz, and X.K. Vidal Continuous glucose monitoring in infants of very low birth weight Neonatology 95 2009 217 223
31. R.M. Turbow, D. Curran-Everett, W.W. Hay, and D. Douglas Jones Cerebral lactate metabolism in near-term fetal sheep Am J Physiol 269 1995 R938 R942
32. J. Hellman, R.C. Vannucci, and E.E. Nardis Blood-brain barrier permeability to lactic acid in the newborn dog: lactate as a cerebral metabolic fuel Pediatr Res 16 1982 40 44 (Pubitemid 12200709)
33. A. Maran, I. Cranston, J. Lomas, I. MacDonald, and S. Amiel Protection by lactate of cerebral function during hypoglycaemia Lancet 343 1994 16 20 (Pubitemid 24017609)
34. P. King, K.H. Parkin, I.A. MacDonald, C. Barber, and R.B. Tattersall Intravenous lactate prevents cerebral dysfunction during hypoglycaemia in insulin-dependent diabetes mellitus Clin Sci 94 1998 157 163 (Pubitemid 28052646)
35. J.J. Spitzer, and J.T. Weng Removal and utilization of ketone bodies by the brain of newborn puppies J Neurochem 19 1972 2169 2173
36. P. Bougneres, C. Lemmel, P. Ferre, and D. Bier Ketone body transport in the human neonate and infant J Clin Invest 77 1986 42 48 (Pubitemid 16101199)
37. B. Persson, G. Settergren, and G. Dahlquist Cerebral arterio-venous difference of acetoacetate and d-b-hydroxybutyrate in children Acta Paediatr Scand 61 1972 273 278
38. H.A. Sloviter, P. Shimkin, and K. Suhara Glycerol as a substrate for brain metabolism Nature 210 1966 1334 1336