Two pairs of epimeric indole alkaloids from catharanthus roseus

Planta Medica

Volumn 77, Issue 15, 2011, Pages 1739-1741

  Wang, Guo Cai ^a   Zhong, Xiang Zhan ^a   Zhang, Dong Mei ^a   Wang, Ying ^a   Zhang, Xiao Qi ^a   Jiang, Ren Wang ^a   Li, Yao Lan ^a   Wang, Jiao ^a   Yao, Xin Sheng ^a   Ye, Wen Cai ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

Apocynaceae; Catharanthus roseus; cytotoxic activity; HepG2 cells; indole alkaloid

Indexed keywords

CATHARANTHUS ROSEUS EXTRACT; CHLORINE; CHLORO 3 OXOTABERSONINE; CHLOROTABERSONINE; CYTOTOXIC AGENT; INDOLE ALKALOID; UNCLASSIFIED DRUG;

ARTICLE; CATHARANTHUS ROSEUS; CELL STRAIN HEPG2; CHEMICAL STRUCTURE; CYTOTOXICITY; DRUG ISOLATION; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ULTRAVIOLET SPECTROSCOPY; X RAY DIFFRACTION;

APOCYNACEAE; CATHARANTHUS ROSEUS;

EID: 80054753523     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1271064     Document Type: Article

References (12)

1. Zu Y G., Luo M, Mu F S., Fu Y J., Wang L. Research advances on alkaloids from Catharanthus roseus and their pharmacological activities. Nat Prod Res Dev 2006 18 325-329 294
2. Himes R H. Interaction of the Catharanthus (vinca) alkaloids with tubulin and microtubules. Pharmacol Ther 1991 51 257-267
3. Jordan M A., Thrower D, Wilson L. Mechanism of inhibition of cell proliferation by vinca alkaloids. Cancer Res 1991 51 2212-2222
4. Zhou X J., Rabmani R. Preclinical and clinical pharmacology of vinca alkaloids. Drugs 1992 44 1-16
5. Ngan V K., Bellman K, Hill B T., Wilson L, Jordan M. Mechanism of mitotic block and inhibition of cell proliferation by the semi-synthetic vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol 2001 60 225-232 (Pubitemid 32595250)
6. Okouneva T, Hill B T., Wilson L, Jordan M A. The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. Mol Cancer Ther 2003 2 427-436
7. Noble R L. The discovery of the vinca alkaloids: chemotherapeutic agents against cancer. Biochem Cell Biol 1990 68 1344-1351
8. Noble R L., Beer C T., Cutts J H. Role of chance observations in chemotherapy: Vinca rosea. Ann NY Acad Sci 1958 76 882-894
9. Neuss N, Gorman M, Hargrove W, Cone N J., Biemann K, Buchi G, Manning R E. Vinca alkaloids: XXI. The structures of the oncolytic alkaloids vinblastine and vincristine. J Am Chem Soc 1964 86 1440-1442
10. McCormack J J. Pharmacology of antitumor bisindole alkaloids from Catharanthus. Brossi A, Suffness M The alkaloids. New York Academic Press 1990 205-226
11. Neuss N, Neuss M N. The therapeutic use of bisindole alkaloids from Catharanthus. Brossi A, Suffness M The alkaloids. New York Academic Press 1990 229-240
12. Kalaus Gy, Greiner I, Kajtár-Peredy M, Brlik J, Szabó L, Szántay Cs. Synthesis of vinca alkaloids and related compounds. 63. A new synthetic pathway for preparing alkaloids and related compounds with the aspidosperma skeleton. Total syntheses of (±)-vincadifformine, (±)-tabersonine, and (±)-3-oxotabersonine. J Org Chem 1993 58 1434-1442 (Pubitemid 23138832)