Poly(ADP-ribosyl)ation Pathways in Mammals: The Advantage of Murine PARG Null Mutation

Methods in Molecular Biology

Volumn 780, Issue , 2011, Pages 337-348

  Zhou, Yiran ^a   Koh, David W ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Comet assay; DNA damage; PAR; PARG; PARP; Poly(ADP ribose); Poly(ADP ribosyl)ation

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE);

ANIMAL; APOPTOSIS; ARTICLE; COMET ASSAY; DNA DAMAGE; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; COMET ASSAY; DNA DAMAGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MICE; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES;

MAMMALIA; MURINAE;

EID: 80054741493     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61779-270-0_20     Document Type: Chapter

References (11)

1. Koh DW, Lawler AM, Poitras MF et al (2004) Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Proc Natl Acad Sci USA 101:17699–17704
2. Cortes U, Tong WM, Coyle DL et al (2004) Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol Cell Biol 24:7163–7178
3. Gao H, Coyle DL, Meyer-Ficca ML et al (2007) Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypo-morphic mutant of poly(ADP-ribose) glycohydrolase. Exp Cell Res 313:984–996
4. Jacobson MK, Jacobson EL (1999) Discovering new ADP-ribose polymer cycles: protecting the genome and more. Trends Biochem Sci 24:415–417
5. Singh NP, McCoy MT, Tice RR et al (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184–191
6. Tanaka S, Kunath T, Hadjantonakis AK et al (1998) Promotion of trophoblast stem cell proliferation by FGF4. Science 282: 2072–2075
7. Nunbhakdi V, Jacobson EL (1987) Effects of a poly(ADP-ribose) polymerase inhibitor on mutation frequencies in dividing and quiescent C3H10T1/2 cells. Mutat Res 180:249–256
8. Pinsky SD, Tew KD, Smulson ME et al (1979) Modification of L1210 cell nuclear proteins by 1-methyl-1-nitrosourea and 1-methyl-3-nitro-1-nitrosoguanidine. Cancer Res 39:923–928
9. van Engeland M, Nieland LJ, Ramaekers FC et al (1998) Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31:1–9
10. Koopman G, Reutelingsperger CP, Kuijten GA et al (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84:1415–1420
11. Darzynkiewicz Z, Bruno S, Del Bino G et al (1992) Features of apoptotic cells measured by flow cytometry. Cytometry 13:795–808