The reserve pool of synaptic vesicles acts as a buffer for proteins involved in synaptic vesicle recycling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 41, 2011, Pages 17183-17188

  Denker, Annette ^a,b   Kroḧnert, Katharina ^a   Buc̈kers, Johanna ^c   Neher, Erwin ^c   Rizzoli, Silvio O ^a  

^a Deutsche Forschungsgemeinschaft   (Germany)

^b INTERNATIONAL MAX PLANCK RESEARCH SCHOOL FOR MOLECULAR BIOLOGY   (Germany)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Buffering; Clathrin; Latrotoxin; Stimulated emission depletion microscopy; Synapsin

Indexed keywords

BUFFER; CALCIUM; CELL PROTEIN; IONOMYCIN; RAB PROTEIN; RABPHILIN; SPIDER VENOM; SYNAPSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; CELL STIMULATION; CONTROLLED STUDY; CYTOSOL; DIFFUSION; IN VITRO STUDY; NERVE FIBER; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SYNAPSE VESICLE;

ANIMALS; BUFFERS; CALCIUM; MICE; MODELS, NEUROLOGICAL; NERVE TISSUE PROTEINS; NEUROMUSCULAR JUNCTION; NEUROTRANSMITTER AGENTS; PRESYNAPTIC TERMINALS; RATS; SOLUBILITY; SPIDER VENOMS; SYNAPSINS; SYNAPTIC TRANSMISSION; SYNAPTIC VESICLES;

ARANEAE; LATRODECTUS;

EID: 80054722414     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112690108     Document Type: Article

References (29)

1. Rizzoli SO, Betz WJ (2005) Synaptic vesicle pools. Nat Rev Neurosci 6:57-69. (Pubitemid 40052139)
2. Denker A, Rizzoli SO (2010) Synaptic vesicle pools: An update. Front Synaptic Neurosci 2:135.
3. Denker A, et al. (2011) A small pool of vesicles maintains synaptic activity in vivo. Proc Natl Acad Sci USA 108:17177-17182.
4. Van der Kloot W (2003) Loading and recycling of synaptic vesicles in the Torpedo electric organ and the vertebrate neuromuscular junction. Prog Neurobiol 71:269-303.
5. Fredj NB, Burrone J (2009) A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapse. Nat Neurosci 12:751-758.
6. Wilhelm BG, Groemer TW, Rizzoli SO (2010) The same synaptic vesicles drive active and spontaneous release. Nat Neurosci 13:1454-1456.
7. Südhof TC (2004) The synaptic vesicle cycle. Annu Rev Neurosci 27:509-547.
8. Shupliakov O (2009) The synaptic vesicle cluster: A source of endocytic proteins during neurotransmitter release. Neuroscience 158:204-210.
9. Willig KI, Rizzoli SO, Westphal V, Jahn R, Hell SW (2006) STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis. Nature 440:935-939.
10. Cesca F, Baldelli P, Valtorta F, Benfenati F (2010) The synapsins: Key actors of synapse function and plasticity. Prog Neurobiol 91:313-348.
11. Takamori S, et al. (2006) Molecular anatomy of a trafficking organelle. Cell 127: 831-846. (Pubitemid 44716256)
12. Henkel AW, Betz WJ (1995) Monitoring of black widow spider venom (BWSV) induced exo-and endocytosis in living frog motor nerve terminals with FM1-43. Neuropharmacology 34:1397-1406.
13. Di Paolo G, De Camilli P (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443:651-657. (Pubitemid 44564702)
14. Chi P, Greengard P, Ryan TA (2001) Synapsin dispersion and reclustering during synaptic activity. Nat Neurosci 4:1187-1193. (Pubitemid 33135623)
15. Rizzoli SO, Betz WJ (2002) Effects of 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran- 4-one on synaptic vesicle cycling at the frog neuromuscular junction. J Neurosci 22:10680-10689. (Pubitemid 36005142)
16. Zilly FE, et al. (2011) Ca2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactions. EMBO J 30:1209-1220.
17. Neher E, Augustine GJ (1992) Calcium gradients and buffers in bovine chromaffin cells. J Physiol 450:273-301.
18. Neher E (1998) Usefulness and limitations of linear approximations to the understanding of Ca++ signals. Cell Calcium 24:345-357.
19. Miller TM, Heuser JE (1984) Endocytosis of synaptic vesicle membrane at the frog neuromuscular junction. J Cell Biol 98:685-698. (Pubitemid 14193303)
20. Mueller VJ, Wienisch M, Nehring RB, Klingauf J (2004) Monitoring clathrin-mediated endocytosis during synaptic activity. J Neurosci 24:2004-2012. (Pubitemid 38292814)
21. Goud B, Faivre-Bauman A, Picart R, Tixier-Vidal A (1991) Subcellular distribution of clathrin in cultured hypothalamic neurons. Biol Cell 72:83-92.
22. Fernández-Alfonso T, Ryan TA (2006) The efficiency of the synaptic vesicle cycle at central nervous system synapses. Trends Cell Biol 16:413-420. (Pubitemid 44118784)
23. Cheng Y, BollW, Kirchhausen T, Harrison SC, Walz T (2007) Cryo-electron tomography of clathrin-coated vesicles: Structural implications for coat assembly. J Mol Biol 365: 892-899. (Pubitemid 44960362)
24. Schikorski T, Stevens CF (1997) Quantitative ultrastructural analysis of hippocampal excitatory synapses. J Neurosci 17:5858-5867. (Pubitemid 27310500)
25. Bai J, Hu Z, Dittman JS, Pym EC, Kaplan JM (2010) Endophilin functions as a membrane- bending molecule and is delivered to endocytic zones by exocytosis. Cell 143:430-441.
26. Pechstein A, Shupliakov O (2010) Taking a back seat: Synaptic vesicle clustering in presynaptic terminals. Front Synaptic Neurosci 2:143.
27. Israel M, Dunant Y, Manaranche R (1979) The present status of the vesicular hypothesis. Prog Neurobiol 13:237-275. (Pubitemid 10198261)
28. Lang T, Rizzoli SO (2010) Membrane protein clusters at nanoscale resolution: More than pretty pictures. Physiology (Bethesda) 25:116-124.
29. Barysch SV, Jahn R, Rizzoli SO (2010) A fluorescence-based in vitro assay for investigating early endosome dynamics. Nat Protoc 5:1127-1137.