5-Hydroxytryptophan attenuates somatic signs of nicotine withdrawal

Journal of Pharmacological Sciences

Volumn 117, Issue 2, 2011, Pages 121-124

  Ohmura, Yu ^a,b   Jutkiewicz, Emily M ^a   Yoshioka, Mitsuhiro ^b   Domino, Edward F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Addiction; Smoking; Tobacco

Indexed keywords

3 HYDROXYBENZYLHYDRAZINE; 5 HYDROXYTRYPTOPHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; IRRITABILITY; MALE; NONHUMAN; RAT; SMOKING CESSATION; TOBACCO DEPENDENCE; WITHDRAWAL SYNDROME;

EID: 80054721879     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11074SC     Document Type: Article

References (15)

1. Hughes JR. Effects of abstinence from tobacco: etiology, animal models, epidemiology, and significance: a subjective review. Nic Tob Res. 2007;9:329-339. (Pubitemid 46404265)
2. Malin DH, Goyarzu P. Rodent models of nicotine withdrawal syndrome. Handb Exp Pharmacol. 2009;192:401-434.
3. Benwell MEM, Balfour DJK. The effects of nicotine administration on 5-HT uptake and biosynthesis in rat brain. Eur J Pharmacol. 1982;84:71-77. (Pubitemid 12005359)
4. Benwell MEM, Balfour DJK, Anderson JM. Smoking-associated changes in the serotonergic systems of discrete regions of human brain. Psychopharmacology. 1990;12:68-72. (Pubitemid 20227530)
5. Benwell MEM, Balfour DJK. Effects of nicotine administration and its withdrawal on plasma corticosterone and brain 5-hydoxyindoles. Psychopharmacology. 1979;63:7-11. (Pubitemid 9227026)
6. Nakamura S, Yue JL, Goshima Y, Miyamae T, Ueda H, Misu Y. Non-effective dose of exogenously applied L-DOPA itself stereo-selectively potentiates postsynaptic D2 receptor-mediated locomotor activities of conscious rats. Neurosci Lett. 1994;170: 22-26.
7. LeSage MG, Keyler DE, Shoeman D, Raphael D, Collins G, Pentel PR. Continuous nicotine infusion reduces nicotine self-administration in rats with 23-h/day access to nicotine. Pharmacol Biochem Behav. 2002;72:279-289. (Pubitemid 34251337)
8. Benowitz NL, Kuyt F, Jacob P 3rd. Circadian blood nicotine concentrations during cigarette smoking. Clin Pharmacol Ther. 1982;32:758-764. (Pubitemid 13093847)
9. Schlosberg AJ, Harvey JA. Effects of L-DOPA and L-5-hydroxytryptophan on locomotor activity of the rat after selective or combined destruction of central catecholamine and serotonin neurons. J Pharmacol Exp Ther. 1979;211:296-304. (Pubitemid 10214540)
10. Shin EJ, Jeong JH, Chung YH, Kim TW, Shin CY, Kim WK, et al. Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats: possible involvement of an impaired synaptic transmission to the 5-HT(2A) receptor. J Pharmacol Sci. 2009;110:401-404.
11. Hashiguti H, Nakahara D, Maruyama W, Naoi M, Ikeda T. Simultaneous determination of in vivo hydroxylation of tyrosine and tryptophan in rat striatum by microdialysis-HPLC: relationship between dopamine and serotonin biosynthesis. J Neural Transm Gen Sect. 1993;93:213-223. (Pubitemid 23272409)
12. Ohmura Y, Jutkiewicz EM, Domino EF. L-DOPA attenuates nicotine withdrawal-induced behaviors in rats. Pharmacol Biochem Behav. 2011;98:522-558.
13. Mannucci C, Tedesco M, Bellomo M, Caputi AP, Calapai G. Long-term effects of nicotine on the forced swimming test in mice: an experimental model for the study of depression caused by smoke. Neurochem Int. 2006;49:481-486. (Pubitemid 44209297)
14. Bowen DJ, Spring B, Fox E. Tryptophan and high-carbohydrate diets as adjuncts to smoking cessation therapy. J Behav Med. 1991;14:97-110.
15. Baumann MH, Williams Z, Zolkowska D, Rothman RB. Serotonin (5-HT) precursor loading with 5-hydroxy-l-tryptophan (5-HTP) reduces locomotor activation produced by (+)-amphetamine in the rat. Drug Alcohol Depend. 2011;114:147-152.