Variation in gentamicin and vancomycin dosage and monitoring in UK neonatal units

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 11, 2011, Pages 2647-2650

  Kadambari, S ^a   Heath, P T ^a   Sharland, M ^a   Lewis, S ^b   Nichols, A ^c   Turner, M A ^d  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c MAYDAY UNIVERSITY HOSPITAL   (United Kingdom)

^d LIVERPOOL WOMEN S HOSPITAL   (United Kingdom)

Author keywords

Aminoglycosides; Antibiotic policy; Antibiotics; Drug monitoring; Neonatal infections

Indexed keywords

GENTAMICIN; VANCOMYCIN;

ARTICLE; BIRTH WEIGHT; CHILD; CLINICAL PRACTICE; DRUG DOSE REGIMEN; DRUG MONITORING; GESTATIONAL AGE; HUMAN; NEWBORN INTENSIVE CARE; PRACTICE GUIDELINE; QUESTIONNAIRE; STRUCTURED QUESTIONNAIRE;

ANTI-BACTERIAL AGENTS; DRUG ADMINISTRATION SCHEDULE; DRUG MONITORING; DRUG UTILIZATION; FEMALE; GENTAMICINS; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; MALE; PHYSICIAN'S PRACTICE PATTERNS; QUESTIONNAIRES; VANCOMYCIN;

EID: 80054704565     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkr351     Document Type: Article

References (19)

1. Fernando AM, Heath PT, Menson EN. Antimicrobial policies in the neonatal units of the United Kingdom and Republic of Ireland. J Antimicrob Chemother 2008; 61: 743-5.
2. National Patient Safety Agency. Review of Patient Safety for Children and Young People, June 2009. http://www.nrls.npsa.nhs.uk/resources/?entryid45=59864 (21 April 2011, date last accessed).
3. Pacifici GM. Clinical pharmacokinetics of aminoglycosides in the neonate: a review. Eur J Clin Pharmacol 2009; 65: 419-27.
4. British National Formulary for Children 2010-2011. http://BNFc.org/BNFc/index.htm (20 April 2011, date last accessed).
5. Vergnano S, Menson E, Kennea N et al. Neonatal infections in England: the NeonIN surveillance network. Arch Dis Child Fetal Neonatal Ed 2011; 96: F9-14.
6. de Hoog M, MoutonJW, van den Anker JN. Vancomycin: pharmacokinetics and administration regimens in neonates. Clin Pharmacokinet 2004; 43: 417-40.
7. Mohr JF, Murray BE. Vancomycin is not obsolete in the treatment of infection caused by methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2007; 44: 1536-42.
8. Moise-Broder PA, Forrest A, Birmingham MC et al. Pharmacodynamics of vancomycin and other antimicrobials in patients with Staphylococcus aureus lower respiratory tract infections. Clin Pharmacokinet 2004; 43: 925-42.
9. Rybak M, Lomaestro B, Rotschafer JC et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm 2009; 66: 82-98.
10. Nielsen EI, Sandström M, Honoré PH et al. Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study. Clin Pharmacokinet 2009; 48: 253-63.
11. Touw DJ, Westerman EM, Sprij AJ. Therapeutic drug monitoring of aminoglycosides in neonates. Clin Pharmacokinet 2009; 48: 71-88.
12. Mercado MCK, Brodsky NL, McGuire MK et al. Extended interval dosing of gentamicin in preterm infants. Am J Perinatol 2004; 21: 73-7.
13. Darmastads GL, Hossain MM, Jana AK et al. Determination of extended-interval gentamicin dosing for neonatal patients in developing countries. Pediatr Infect Dis J 2007; 26: 501-7.
14. Bleyzac N, Varnier V, Labaune JM et al. Population pharmacokinetics of amikacin at birth and interindividual variability in renal maturation. Eur J Clin Pharmacol 2001; 57: 499-504.
15. Wysocki M, Delatour F, Faurisson F et al. Continuous versus intermittent infusion of vancomycin in severe staphylococcal infections: prospective multicenter randomized study. Antimicrob Agents Chemother 2001; 45: 2460-7.
16. Lowdin E, Odenholt I, Cars O. In vitro studies of pharmacodynamic properties of vancomycin against Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother 1998; 42: 2739-44.
17. Plan O, Cambonie G, Barbotte E et al. Continuous-infusion vancomycin therapy for preterm neonates with suspected or documented Gram-positive infections: a new dosage schedule. Arch Dis Child Fetal Neonatal Ed 2008; 93: F418-21.
18. Oudin C, Vialet R, Boulamery A et al. Vancomycin prescription in neonates and young infants: toward a simplified dosage. Arch Dis Child Fetal Neonatal Ed 2011; doi:10.1136/adc.2010.196402.
19. Turner MA, Lewis S, Hawcutt DB et al. Prioritising neonatal medicines research: UK Medicines for Children Research Network scoping survey. BMC Pediatr 2009; 9: 50.