Effects of dexmedetomidine on oxygenation during one-lung ventilation for thoracic surgery in adults

Journal of Minimal Access Surgery

Volumn 7, Issue 4, 2011, Pages 227-231

  Kernan, Scott ^a   Rehman, Saif ^a   Meyer, Thomas ^a   Bourbeau, Joan ^a   Caron, Norm ^b   Tobias, Joseph D ^c  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

Dexmedetomidine; hypoxic pulmonary vasoconstriction; one lung ventilation; thoracoscopy; thoracotomy

Indexed keywords

CISATRACURIUM; DESFLURANE; DEXMEDETOMIDINE; FENTANYL; PHENYLEPHRINE; PLACEBO; PROPOFOL;

ADULT; ARTERIAL GAS; ARTICLE; BISPECTRAL INDEX; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFECT; FEMALE; HEART RATE; HUMAN; HYPOXIC LUNG VASOCONSTRICTION; LUNG VENTILATION; MALE; MEAN ARTERIAL PRESSURE; OXYGENATION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TERTIARY HEALTH CARE; THORAX SURGERY;

EID: 80054692068     PISSN: 09729941     EISSN: 19983921     Source Type: Journal    
DOI: 10.4103/0972-9941.85645     Document Type: Article

References (12)

1. Karzai W, Schwarzkopf K. Hypoxemia during one-lung ventilation. Anesthesiology 2009;110:402-11.
2. Campos JH. Current techniques for perioperative lung isolation in adults. Anesthesiology 2002;97:1295-301. (Pubitemid 35265586)
3. Benumof JF, Augustine SD, Gibbons JA. Halothane and isoflurane only slightly impair arterial oxygenation during one-lung ventilation in patients undergoing thoracotomy. Anesthesiology 1987;67:910-4.
4. Wang JY, Russell GN, Page RD, Oo A, Pennefather SH. A comparison of the effects of desflurane and isoflurane on arterial oxygenation during one-lung ventilation. Anaesthesia 2000;55:167-73. (Pubitemid 30092996)
5. Nakayama M, Murray PA. Ketamine preserves and propofol potentiates hypoxic pulmonary vasoconstriction compared with the conscious state in chronically instrumented dogs. Anesthesiology 1999;91:760-71. (Pubitemid 29418658)
6. Venn RM, Bradshaw CJ, Spencer R, Brealey D, Caudwell E, Naughton C, et al. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 1999;54:1136-42.
7. Bloor BC, Ward DS, Belleville J P, Maze M. Effects of intravenous dexmedetomidine in humans. II: Hemodynamic changes. Anesthesiology 1992;77:1134-42. (Pubitemid 23001124)
8. Moutafis M, Dalibon N, Colchen A, Fischler M. Improving oxygenation during bronchopulmonary lavage using nitric oxide inhalation and almitrine infusion. Anesth Analg 1999;89:302-4. (Pubitemid 29367704)
9. Silva-Costa-Gomes T, Gallart L, Vallès J, Trillo L, Minguella J, Puig MM. Low-vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open-chest one-lung ventilation. Br J Anaesth 2005;95:410-6. (Pubitemid 41487357)
10. Talke P, Richardson CA, Scheinin M, Fisher DM. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg 1997;85:1136-42. (Pubitemid 27471539)
11. Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thorborg P, et al. The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg 2000;90:834-9. (Pubitemid 30190786)
12. Kästner SB, Kull S, Kutter A P, Boller J, Bettschart-Wolfensberger R, Huhtinen MK. Cardiopulmonary effects of dexmedetomidine in sevofluraneanesthetized sheep with and without nitric oxide inhalation. Am J Vet Res 2005;66:1496-502. (Pubitemid 41614658)