A critique of statistical hypothesis testing in clinical research

Journal of Ayurveda and Integrative Medicine

Volumn 2, Issue 3, 2011, Pages 105-114

  Raha, Somik ^a  

^a NONE   (United States)

Author keywords

Bayesian; decision analysis; statistical hypothesis testing

Indexed keywords

ACETYLSALICYLIC ACID; PLACEBO;

ARTICLE; AYURVEDA; BAYES THEOREM; CLINICAL RESEARCH; DECISION MAKING; ERROR; GASTROINTESTINAL SYMPTOM; HEALTH CARE COST; HEART INFARCTION; HEARTBURN; HUMAN; HYPOTHESIS; LEGAL ASPECT; LUNG CANCER; MEDICAL ETHICS; MEDICAL LITERATURE; METHODOLOGY; NAUSEA; POLICY; PRACTICE GUIDELINE; PREVALENCE; PRIORITY JOURNAL; PROBABILITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SOCIETY; STANDARD; STATISTICAL ANALYSIS;

EID: 80054683111     PISSN: 09759476     EISSN: 09762809     Source Type: Journal    
DOI: 10.4103/0975-9476.85548     Document Type: Article

References (28)

1. Patwardhan B. Ayurveda GCP guidelines: Need for freedom from RCT ascendancy in favor of whole system approach. J Ayurveda Integr Med 2011;2:1-4.
2. Raut AA. Integrative endeavor for renaissance in ayurveda. J Ayurveda Integr Med 2011;2:5-8.
3. Singh RH. Exploring issues in the development of ayurvedic research methodology. J Ayurveda Integr Med 2010;1:91-5.
4. th International Conference on Operational Research; 1996. p. 55-77.
5. Feynman R. The value of science. Epilogue. What do you care what other people think? W. W. Norton & Company; 2001.
6. Cook JD. Most published research results are false. Blog: Available from: http://www.johndcook.com/blog/2008/02/07/most-published-research-results-are- false/. [Last accessed on 2011 Oct. 04].
7. Cohen J. The earth is round (P<.05). Am Psychol 1994;49:997-1003.
8. Bakan D. The test of significance in psychological research. Psychol Bull 1966;66:423-37.
9. Ioannidis J. Contradicted and initially stronger effects in highly cited clinical research. JAMA 2005;294:218-28. (Pubitemid 41043792)
10. Lehrer J. The truth wears off. The New Yorker, 2010.
11. Howard RA. Decision analysis: Practice and promise. Manage Sci 1988;34:679.
12. Ioannidis JP. Why most published research findings are false. PLoS Med 2005;2:e124.
13. Howard RA. Speaking of decisions: Precise decision language. Decision Analysis. 2004;1:71-8.
14. Howard RA. Decision analysis: Perspectives on inference, decision, and experimentation. Proceedings of the IEEE; 1970:825-6.
15. Final report on the aspirin component of the ongoing physicians' health study. N Engl J Med 1989;321:129-35.
16. Gonick L, Smith W. Cartoon guide to statistics. Harper Perennial, New York; 1993.
17. Tversky A, Kahneman D. Judgment under uncertainty: Heuristics and biases. Adv Sci 2011;185:1124-31.
18. Kahneman D, Knetsch JL. Valuing public goods: The purchase of moral satisfaction. J Environ Econ Manage 1992;22:57-70.
19. Howard RA. On making life and death decisions. In Howard, R. and Matheson, J., editors, Readings on the Principles and Applications of Decision Analysis, 1980;2:483-506. Strategic Decisions Group, Menlo Park, CA.
20. Howard RA. On fates comparable to death. Risk Anal 1984;30:407-22.
21. Maslow AH. The psychology of science: A reconnaissance. Richmond, CA: Maurice Bassett Publishing; 2004.
22. Guidance for the use of bayesian statistics in medical device clinical trials. Available from: FDA Website: http://www.fda.gov/MedicalDevices/ DeviceRegulationandGuidance/GuidanceDocuments/ucm071072.htm. [Last accessed on 2011 Oct. 4].
23. Taleb NN. The black swan. Canada: Random House; 2008.
24. Summary of the herbal medicines advisory committee meeting held on thursday 19 november 2009, November 2009. Available from: http://www.mhra.gov. uk/home/groups/l-cs-el/documents/committeedocument/con090833.pdf. [Last accessed on 2011 Sep. 1]
25. Howard RA. The Foundations of Decision Analysis Revisited. Chapter 3. Cambridge: Cambridge University Press; 2007. Available from: http://www.usc.edu/dept/create/assets/001/50843.pdf. [Last accessed on 2011 Sep. 01]
26. Spetzler CS, Arnold R, Lang J. Bringing quality to board decisions. The Corporate Board, 26 (150): 1-2, January/February 2005. Reprint available from: http://www.sdg. com/article-pdfs/BoardDecisionQuality.pdf. [Last accessed on 2011 Sep. 01]
27. Rawlins M. De Testimonio: On the evidence for decisions about the use of therapeutic interventions. Clin Med 2008;8:579-88.
28. Jaynes ET. Confidence Intervals vs Bayesian Intervals. Foundations of Probability Theory, Statistical Inference, and Statistical Theories of Science, W. L. Harper and C. A. Hooker (eds.), D. Reidel, Dordrecht, 1976:178. Available from: http://bayes.wustl.edu/etj/articles/confidence.pdf. [Last accessed on 2011 Sep. 1]