Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple β-lactamases

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 11, 2011, Pages 4990-4998

  Wagner, R Doug ^a   Johnson, Shemedia J ^a   Cerniglia, Carl E ^a   Erickson, Bruce D ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BACTERIUM LYSATE; BETA LACTAMASE; CEFTIOFUR; CEFTRIAXONE; METALLO BETA LACTAMASE;

ANAEROBIC BACTERIUM; ANIMAL EXPERIMENT; ARTICLE; BACILLUS CEREUS; BACILLUS MYCOIDES; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATION; BACTEROIDES; BIFIDOBACTERIUM BREVE; CATTLE; CLOSTRIDIUM; COLON; CONTROLLED STUDY; DRUG DEGRADATION; DRUG INACTIVATION; EUBACTERIUM BIFORME; FECES; FUNGUS IDENTIFICATION; FUNGUS ISOLATION; GRAM NEGATIVE ANAEROBIC BACTERIA; GRAM NEGATIVE FACULTATIVELY ANAEROBIC RODS; GRAM POSITIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE FLORA; ISOELECTRIC FOCUSING; MASS SPECTROMETRY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANIMALS; BACILLUS CEREUS; BACTEROIDES; BETA-LACTAMASES; BIFIDOBACTERIUM; CATTLE; CEFTRIAXONE; CEPHALOSPORINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOSTRIDIUM; EUBACTERIUM; INTESTINES; MASS SPECTROMETRY; POLYMERASE CHAIN REACTION;

EID: 80054679836     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00008-11     Document Type: Article

References (49)

1. Alali, W. Q., H. M. Scott, B. Norby, W. Gebreyes, and G. H. Loneragan. 2009. Quantification of the bla(CMY-2) in feces from beef feedlot cattle administered three different doses of ceftiofur in a longitudinal controlled field trial. Foodborne Pathog. Dis. 6:917-924.
2. Alcaine, S. D., et al. 2005. Ceftiofur-resistant Salmonella strains isolated from dairy farms represent multiple widely distributed subtypes that evolved by independent horizontal gene transfer. Antimicrob. Agents Chemother. 49: 4061-4067. (Pubitemid 41400947)
3. Almeida, F. S., and M. J. Avila-Campos. 2006. Plasmid-related resistance to cefoxitin in species of Bacteroides fragilis group isolated from intestinal tracts of calves. Curr. Microbiol. 53:440-443.
4. Aminov, R. I., et al. 2002. Development, validation, and application of PCR primers for detection of tetracycline efflux genes of Gram-negative bacteria. Appl. Environ. Microbiol. 68:1786-1793. (Pubitemid 34279986)
5. Atlas, R. M. 1993. Handbook of microbiological media, p. 76. CRC Press, Boca Raton, FL.
6. Beconi-Barker, M. G., et al. 1995. Determination of ceftiofur and its desfuroylceftiofur- related metabolites in swine tissues by high-performance liquid chromatography. J. Chromatogr. B Biomed. Appl. 673:231-244.
7. Bush, K., and G. A. Jacoby. 2010. Updated functional classification of β-lactamases. Antimicrob. Agents Chemother. 54:969-976.
8. Copeland, A., et al. 2007. Complete sequence of chromosome 1 of Desulfovibrio vulgaris subsp. vulgaris DP4. GenBank accession number NC-008751. National Center for Biotechnology Information, NIH, Bethesda, MD. Accessed 28 May 2009.
9. Copeland, A., et al. 2007. Complete sequence of chromosome of Sphingomonas wittichii RW1. GenBank accession number NC-009511. National Center for Biotechnology Information, NIH, Bethesda, MD. Accessed 28 May 2009.
10. Daniels, J. B., et al. 2009. Role of ceftiofur in selection and dissemination of blaCMY-2-mediated cephalosporin resistance in Salmonella enterica and commensal Escherichia coli isolates from cattle. Appl. Environ. Microbiol. 75: 3648-3655.
11. de Vries-Hospers, H., G. Jansen, R. Tonk, D. Oenema, and D. van der Waaij. 1993. The in vitro inactivation of thirteen β-lactam antibiotics by other mechanisms than adsorption to faecal substance. Infection 21:127-130. (Pubitemid 23112604)
12. Dodson, R. J., et al. 2009. Genome sequence of Bacillus cereus 03BB102. GenBank accession number NC-009511. National Center for Biotechnology Information, NIH, Bethesda, MD. Accessed 28 May 2009.
13. Donaldson, S. C., et al. 2006. Molecular epidemiology of ceftiofur-resistant Escherichia coli isolates from dairy calves. Appl. Environ. Microbiol. 72: 3940-3948. (Pubitemid 43894855)
14. Dowd, S. E., et al. 2008. Evaluation of the bacterial diversity in the feces of cattle using 16S rDNA bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP). BMC Microbiol. 8:125-133.
15. Dunne, E. F., et al. 2000. Emergence of domestically acquired ceftriaxone-resistant Salmonella infections associated with AmpC β-lactamase. JAMA 284:3151-3156. (Pubitemid 32039078)
16. Fey, P. D., et al. 2000. Ceftriaxone-resistant Salmonella infection acquired by a child from cattle. N. Engl. J. Med. 342:1242-1249. (Pubitemid 30235953)
17. Gilbertson, T. J., et al. 1990. Environmental fate of ceftiofur sodium, a cephalosporin antibiotic. Role of animal excreta in its decomposition. J. Agric. Food Chem. 38:890-894.
18. Gronstad, A., T. Kristensen, E. Hornes, and A. B. Kolsto. 1991. The beta-lactamase I gene from Bacillus mycoides. GenBank accession number X62244. National Center for Biotechnology Information, NIH, Bethesda, MD. Accessed 28 May 2009.
19. Heritage, J., P. M. Hawkey, N. Todd, and I. J. Lewis. 1992. Transposition of the gene encoding a TEM-12 extended-spectrum β-lactamase. Antimicrob. Agents Chemother. 36:1981-1986.
20. Hornish, R. E., and S. F. Kotarski. 2002. Cephalosporins in veterinary medicine - ceftiofur use in food animals. Curr. Top. Med. Chem. 2:717-731.
21. Hu, G. Z., et al. 2008. Phenotypic and molecular characterization of TEM- 116 extended-spectrum beta-lactamase produced by a Shigella flexneri clinical isolate from chickens. FEMS Microbiol. Lett. 279:162-166.
22. Hu, G.-Z., et al. 2006. GenBank accession number DQ849329. National Center for Biotechnology Information, NIH, Bethesda, MD. Accessed 28 May 2009.
23. Hu, G.-Z., et al. 2006. GenBank accession number DQ849330. National Center for Biotechnology Information, NIH, Bethesda, MD. Accessed 28 May 2009.
24. Hussain, M., F. I. J. Pastor, and J. O. Lampen. 1987. Cloning and sequencing of the blaZ gene encoding β-lactamase III, a lipoprotein of Bacillus cereus 569/H. J. Bacteriol. 169:579-586. (Pubitemid 17010865)
25. Jaglan, P. S., et al. 1992. Depletion of intramuscularly injected ceftiofur from the milk of dairy cows. J. Dairy Sci. 75:1870-1876.
26. Koshy, K. T., and A. R. Cazers. 1997. Controlled hydrolysis of ceftiofur sodium, a broad-spectrum cephalosporin; isolation and identification of hydrolysis products. J. Pharm. Sci. 86:389-395. (Pubitemid 27113777)
27. Lee, J.-H., et al. 2008. Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth. BMC Genomics 9:247-265.
28. Madgwick, P. J., and S. G. Waley. 1987. Beta-lactamase I from Bacillus cereus. Structure and site-directed mutagenesis. Biochem. J. 248:657-662.
29. Marshall, W. F., and J. E. Blair. 1999. The cephalosporins. Mayo Clin. Proc. 74:187-195. (Pubitemid 29085217)
30. Matthew, M., A. M. Harris, M. J. Marshall, and G. W. Ross. 1975. The use of analytical focusing for detection and identification of β-lactamases. J. Gen. Microbiol. 88:169-178.
31. Mendes, R. E., et al. 2007. Rapid detection and identification of metallo-β- lactamase-encoding genes by multiplex real-time PCR assay and melt curve analysis. J. Clin. Microbiol. 45:544-547.
32. Morin, A.-S., L. Poirel, F. Mory, R. Labia, and P. Nordmann. 2002. Biochemical- genetic analysis and distribution of DES-1, an Ambler class A extended-spectrum β-lactamase from Desulfovibrio desulfuricans. Antimicrob. Agents Chemother. 46:3215-3222.
33. Olson, S. C., et al. 1998. In vitro metabolism of ceftiofur in bovine tissues. J. Vet. Pharmacol. Ther. 21:112-120. (Pubitemid 28179085)
34. Parker, A. C., and C. J. Smith. 1993. Genetic and biochemical analysis of a novel Ambler class A β-lactamase responsible for cefoxitin resistance in Bacteroides species. Antimicrob. Agents Chemother. 37:1028-1036. (Pubitemid 23141316)
35. Payne, D. J., R. Cramp, J. H. Bateson, J. Neale, and D. Knowles. 1994. Rapid identification of metallo- and serine β-lactamases. Antimicrob. Agents Chemother. 38:991-996. (Pubitemid 24150827)
36. Perry, T. R., and J. J. Schentag. 2001. Clinical use of ceftriaxone. A pharmacokinetic- pharmacodynamic perspective on the impact of minimum inhibitory concentration and serum protein binding. Clin. Pharmacokinet. 40: 685-694. (Pubitemid 32954990)
37. Philippon, A., G. Arlet, and G. A. Jacoby. 2002. Plasmid-determined AmpCtype β-lactamases. Antimicrob. Agents Chemother. 46:1-11.
38. Rafii, F., et al. 2009. Isolation of bacterial strains from bovine fecal microflora capable of degradation of ceftiofur. Vet. Microbiol. 139:89-96.
39. Samitz, E. M., S. S. Jang, and D. C. Hirsh. 1996. In vitro susceptibilities of selected obligate anaerobic bacteria obtained from bovine and equine sources to ceftiofur. J. Vet. Diagn. Invest. 8:121-123. (Pubitemid 126673684)
40. SHV gene. GenBank accession number EF373973. National Center for Biotechnology Information, NIH, Bethesda, MD. Accessed 28 May 2009.
41. Shimizu, T., et al. 2002. Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater. Proc. Natl. Acad. Sci. U. S. A. 99:996-1001. (Pubitemid 34106624)
42. Singer, R. S., S. K. Patterson, and R. L. Wallace. 2008. Effects of therapeutic ceftiofur administration to dairy cattle on Escherichia coli dynamics in the intestinal tract. Appl. Environ. Microbiol. 74:6956-6962.
43. Smith, C. J., T. K. Bennett, and A. C. Parker. 1994. Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cblA, encoding the species-specific β-lactamase. Antimicrob. Agents Chemother. 38:1711-1715. (Pubitemid 24250714)
44. Teeter, J. S., and R. D. Meyerhoff. 2003. Aerobic degradation of tylosin in cattle, chicken, and swine excreta. Environ. Res. 93:45-51.
45. Thompson, J. S., and M. H. Malamay. 1990. Sequencing the gene for an imipenem-cefoxitin-hydrolyzing enzyme (CfiA) from Bacteroides fragilis TAL2480 reveals strong similarity between CfiA and Bacillus cereus β-lactamase II. J. Bacteriol. 172:2584-2593. (Pubitemid 20141414)
46. Tragesser, L. A., T. E. Wittum, J. A. Funk, P. L. Winokur, and P. J. Rajala- Schultz. 2006. Association between ceftiofur use and isolation of Escherichia coli with reduced susceptibility to ceftriaxone from fecal samples of dairy cows. Am. J. Vet. Res. 67:1696-1700. (Pubitemid 44605286)
47. United States Food and Drug Administration Center for Veterinary Medicine. Freedom of information summary. Original new animal drug application Nada 141-239. Spectramast dc sterile suspension (ceftiofur hydrochloride) for the treatment of subclinical mastitis in dairy cattle at the time of dry off associated with Staphylococcus aureus, Streptococcus dysgalactiae, and Streptococcus uberis. http://www.fda.gov/downloads/AnimalVeterinary/Products/ ApprovedAnimalDrugProducts /FOIADrugSummaries/ucm118053.pdf. Accessed 26 April 2011.
48. United States Food and Drug Administration Center for Veterinary Medicine. Freedom of information summary. Original new animal drug application Nada 140-338. Provides for the use of ceftiofur sodium (NAXCEL® sterile powder) in cattle for a new indication. http://www.fda.gov/AnimalVeterinary/ Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM049774. Accessed 26 April 2011.
49. Zhang, Z., S. Schwartz, L. Wagner, and W. Miller. 2000. A greedy algorithm for aligning DNA sequences. J. Comput. Biol. 7:203-214. (Pubitemid 30412170)