A systematic review of morphea treatments and therapeutic algorithm

Journal of the American Academy of Dermatology

Volumn 65, Issue 5, 2011, Pages 925-941

  Zwischenberger, Brittany A ^a   Jacobe, Heidi T ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

Author keywords

localized scleroderma; therapeutics

Indexed keywords

BOSENTAN; CALCIPOTRIOL; CALCITRIOL; CLOBETASOL; COLLAGENASE; CORTICOSTEROID; CYCLOSPORIN; GAMMA INTERFERON; HYDROXYCHLOROQUINE; INFLIXIMAB; MEPREDNISONE; MESSENGER RNA; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PENICILLAMINE; PENICILLIN G; PREDNISOLONE; PSORALEN; STANOZOLOL; STEROID; TACROLIMUS; TRIAMCINOLONE;

ABDOMINAL PAIN; ADD ON THERAPY; ALGORITHM; ARTICLE; BROADBAND ULTRAVIOLET A RADIATION; CLINICAL ASSESSMENT TOOL; COMPRESSION THERAPY; CORTICOSTEROID THERAPY; DEBRIDEMENT; DIARRHEA; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG PULSE THERAPY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EOSINOPHILIC FASCIITIS; EVIDENCE BASED MEDICINE; HEADACHE; HUMAN; LOW LEVEL LASER THERAPY; MONOTHERAPY; MORPHEA; NAUSEA; NEPHROTIC SYNDROME; PRIORITY JOURNAL; PROTEINURIA; PRURITUS; PUVA; QUALITY OF LIFE; SKINFOLD THICKNESS; SUBJECTIVE CLINICAL SCLEROSIS SCALE; SYSTEMATIC REVIEW; SYSTEMIC THERAPY; THERAPEUTIC ALGORITHM; TREATMENT OUTCOME; ULTRAVIOLET A RADIATION; UNSPECIFIED SIDE EFFECT;

ADRENAL CORTEX HORMONES; ALGORITHMS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; CALCITRIOL; CLINICAL TRIALS AS TOPIC; EVIDENCE-BASED MEDICINE; HUMANS; IMMUNOLOGIC FACTORS; IMMUNOSUPPRESSIVE AGENTS; METHOTREXATE; PUVA THERAPY; SCLERODERMA, LOCALIZED; TACROLIMUS; TREATMENT OUTCOME; ULTRAVIOLET THERAPY; VITAMIN D;

EID: 80054115914     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2010.09.006     Document Type: Article

References (60)

1. F. Zulian, B.H. Athreya, R. Laxer, A.M. Nelson, S.K. Feitosa de Oliveira, and M.G. Punaro Juvenile localized scleroderma: clinical and epidemiological features in 750 children; an international study Rheumatology (Oxford) 45 2006 614 620
2. L.S. Peterson, A.M. Nelson, W.P. Su, T. Mason, W.M. O'Fallon, and S.E. Gabriel The epidemiology of morphea (localized scleroderma) in Olmsted County 1960-1993 J Rheumatol 24 1997 73 80
3. J.J. Leitenberger, R.L. Cayce, R.W. Haley, B. Adams-Huet, P.R. Bergstresser, and H.T. Jacobe Distinct autoimmune syndromes in morphea: a review of 245 adult and pediatric cases Arch Dermatol 145 2009 545 550
4. S.C. Li, B.M. Feldman, G. Higgins, K. Haines, M. Punaro, and K. O'Neil Treatment of pediatric localized scleroderma: results of a survey of North American pediatric rheumatologists J Rheumatol 37 2010 175 181
5. Creating a framework for "best evidence" approaches in systematic reviews. Am J Prev Medicine. 2010 [cited 2011 April 26]. Available from: http://www.ahrq.gov/clinic/tp/bestevtp.htm.
6. M. Kerscher, M. Meurer, C. Sander, M. Volkenandt, P. Lehmann, and G. Plewig PUVA bath photochemotherapy for localized scleroderma: evaluation of 17 consecutive patients Arch Dermatol 132 1996 1280 1282
7. M. Grundmann-Kollmann, F. Ochsendorf, T.M. Zollner, K. Spieth, E. Sachsenberg-Studer, and R. Kaufmann PUVA-cream photochemotherapy for the treatment of localized scleroderma J Am Acad Dermatol 43 2000 675 678
8. M. El-Mofty, H. Zaher, M. Bosseila, R. Yousef, and B. Saad Low-dose broad-band UVA in morphea using a new method for evaluation Photodermatol Photoimmunol Photomed 16 2000 43 49
9. M.A. de Rie, D.N. Enomoto, H.J. de Vries, and J.D. Bos Evaluation of medium-dose UVA1 phototherapy in localized scleroderma with the cutometer and fast Fourier transform method Dermatology 207 2003 298 301
10. N.R. Camacho, J.E. Sanchez, R.F. Martin, J.R. Gonzalez, and J.L. Sanchez Medium-dose UVA1 phototherapy in localized scleroderma and its effect in CD34-positive dendritic cells J Am Acad Dermatol 45 2001 697 699
11. C.J. Gruss, G. Von Kobyletzki, S.C. Behrens-Williams, J. Lininger, T. Reuther, and M. Kerscher Effects of low dose ultraviolet A-1 phototherapy on morphea Photodermatol Photoimmunol Photomed 17 2001 149 155
12. C. Gruss, J.A. Reed, P. Altmeyer, N.S. McNutt, and M. Kerscher Induction of interstitial collagenase (MMP-1) by UVA-1 phototherapy in morphea fibroblasts Lancet 350 1997 1295 1296
13. F. Wang, L. Garza, S. Cho, R. Kafi, C. Hammerberg, and T. Quan Effect of increased pigmentation on the antifibrotic response of human skin to UV-A1 phototherapy Arch Dermatol 144 2008 851 858
14. H.T. Jacobe, R. Cayce, and J. Nguyen UVA1 phototherapy is effective in darker skin: a review of 101 patients of Fitzpatrick skin types I-V Br J Dermatol 159 2008 691 696
15. C. Romano, P. Rubegni, G. De Aloe, E. Stanghellini, G. D'Ascenzo, and L. Andreassi Extracorporeal photochemotherapy in the treatment of eosinophilic fasciitis J Eur Acad Dermatol Venereol 17 2003 10 13
16. A. Kreuter, J. Hyun, M. Stucker, A. Sommer, P. Altmeyer, and T. Gambichler A randomized controlled study of low-dose UVA1, medium-dose UVA1, and narrowband UVB phototherapy in the treatment of localized scleroderma J Am Acad Dermatol 54 2006 440 447
17. M. El-Mofty, W. Mostafa, S. Esmat, R. Youssef, M. Bousseila, and N. Nagi Suggested mechanisms of action of UVA phototherapy in morphea: a molecular study Photodermatol Photoimmunol Photomed 20 2004 93 100
18. M. El-Mofty, W. Mostafa, M. El-Darouty, M. Bosseila, H. Nada, and R. Yousef Different low doses of broad-band UVA in the treatment of morphea and systemic sclerosis Photodermatol Photoimmunol Photomed 20 2004 148 156
19. M. Kerscher, M. Volkenandt, M. Meurer, P. Lehmann, G. Plewig, and M. Röcken Treatment of localised scleroderma with PUVA bath photochemotherapy Lancet 343 1994 1233
20. M. Kerscher, T. Dirschka, and M. Volkenandt Treatment of localised scleroderma by UVA1 phototherapy Lancet 346 1995 1166
21. P.G. Sator, S. Radakovic, K. Schulmeister, H. Honigsmann, and A. Tanew Medium-dose is more effective than low-dose ultraviolet A1 phototherapy for localized scleroderma as shown by 20-MHz ultrasound assessment J Am Acad Dermatol 60 2009 786 791
22. H. Stege, M. Berneburg, S. Humke, M. Klammer, M. Grewe, and S. Grether-Beck High-dose UVA1 radiation therapy for localized scleroderma J Am Acad Dermatol 36 1997 938 944
23. M. Yildirim, V. Baysal, B.C. Aridogan, D. Kesici, and I. Erturan Pansclerotic morphea treated with UVA: a case report J Dermatol 30 2003 625 627
24. M.M. Hulshof, J.N. Bouwes Bavinck, W. Bergman, A.A. Masclee, L. Heickendorff, and F.C. Breedveld Double-blind, placebo-controlled study of oral calcitriol for the treatment of localized and systemic scleroderma J Am Acad Dermatol 43 2000 1017 1023
25. E.F. Elst, L.W. van Suijlekom-Smit, and A.P. Oranje Treatment of linear scleroderma with oral 1,25-dihydroxyvitamin D3 (calcitriol) in seven children Pediatr Dermatol 16 1999 53 58
26. A.H. Rook, B. Freundlich, B.V. Jegasothy, M.I. Perez, W.G. Barr, S. Jimenez, R.L. Rietschel, B. Wintroub, M. Kahaleh, and J. Varga Treatment of systemic sclerosis with extracorporeal photochemotherapy. Results of a multicenter trial Arch Dermatol 128 1992 337 346
27. H. Zachariae, P. Bjerring, L. Halkier-Sørensen, L. Heickendorff, and K. Søndergaard Skin scoring in systemic sclerosis: a modification - relations to subtypes and the aminoterminal propeptide of type III procollagen (PIIINP) Acta Derm Venereol 74 1994 444 446
28. F. Rodnan, E. Lipinski, and J. Luksick Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma Arthritis Rheum 22 1979 130 140
29. M.M. Hulshof, S. Pavel, F.C. Breedveld, B.A. Dijkmans, and B.J. Vermeer Oral calcitriol as a new therapeutic modality for generalized morphea Arch Dermatol 130 1994 1290 1293
30. B.B. Cunningham, I.D. Landells, C. Langman, D.E. Sailer, and A.S. Paller Topical calcipotriene for morphea/linear scleroderma J Am Acad Dermatol 39 1998 211 215
31. A. Kreuter, T. Gambichler, A. Avermaete, T. Jansen, M. Hoffmann, and K. Hoffmann Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea Pediatr Dermatol 18 2001 241 245
32. M.B. Kahaleh, G.L. Sultany, E.A. Smith, J.E. Huffstutter, C.B. Loadholt, and E.C. LeRoy A modified skin scoring method Clin Exp Rheumatol 4 1986 367 369
33. M.M. Seyger, F.H. van den Hoogen, T. de Boo, and E.M. de Jong Low-dose methotrexate in the treatment of widespread morphea J Am Acad Dermatol 39 1998 220 225
34. M.M. Tollefson, and P.M. Witman En coup de sabre morphea and Parry-Romberg syndrome: a retrospective review of 54 patients J Am Acad Dermatol 56 2007 257 263
35. Y. Uziel, B.M. Feldman, B.R. Krafchik, R.S. Yeung, and R.M. Laxer Methotrexate and corticosteroid therapy for pediatric localized scleroderma J Pediatr 136 2000 91 95
36. A. Kreuter, T. Gambichler, F. Breuckmann, S. Rotterdam, M. Freitag, and M. Stuecker Pulsed high-dose corticosteroids combined with low-dose methotrexate in severe localized scleroderma Arch Dermatol 141 2005 847 852
37. C. Appelhans, F. Breuckmann, T. Gambichler, N.H. Brockmeyer, P. Altmeyer, and A. Kreuter Unilateral generalized morphea is a rare variant of localized scleroderma Eur J Med Res 11 2006 152 156
38. H. Kawashima, C. Watanabe, Y. Kashiwagi, S. Sato, H. Ioi, and M. Sasamoto Therapy of childhood generalized morphea: case reports and reviews of the literature of Japanese cases Pediatr Int 48 2006 342 345
39. L. Weibel, M.C. Sampaio, M.T. Visentin, K.J. Howell, P. Woo, and J.I. Harper Evaluation of methotrexate and corticosteroids for the treatment of localized scleroderma (morphea) in children Br J Dermatol 155 2006 1013 1020
40. G. Mancuso, and R.M. Berdondini Localized scleroderma: response to occlusive treatment with tacrolimus ointment Br J Dermatol 152 2005 180 182
41. K.H. Fiala, M.J. Wells, K.A. Mullinax, C.L. Stetson, and B.R. Paulger Linear morphea presenting as acquired unilateral edema Pediatr Dermatol 24 2007 147 150
42. C. Stefanaki, K. Stefanaki, G. Kontochristopoulos, C. Antoniou, A. Stratigos, and E. Nicolaidou Topical tacrolimus 0.1% ointment in the treatment of localized scleroderma: an open label clinical and histological study J Dermatol 35 2008 712 718
43. N. Hunzelmann, S. Anders, G. Fierlbeck, R. Hein, K. Herrmann, and M. Albrecht Double-blind, placebo-controlled study of intralesional interferon gamma for the treatment of localized scleroderma J Am Acad Dermatol 36 1997 433 435
44. G. Martini, A.V. Ramanan, F. Falcini, H. Girschick, D.P. Goldsmith, and F. Zulian Successful treatment of severe or methotrexate-resistant juvenile localized scleroderma with mycophenolate mofetil Rheumatology (Oxford) 48 2009 1410 1413
45. M. Schlaak, H. Friedlein, F. Kauer, R. Renner, C. Rogalski, and J.C. Simon Successful therapy of a patient with therapy recalcitrant generalized bullous scleroderma by extracorporeal photopheresis and mycophenolate mofetil J Eur Acad Dermatol Venereol 22 2008 631 633
46. M.T. Dytoc, J. Man, J. Liao, and L. Fiorillo Use of imiquimod cream in the treatment of localized morphea J Am Acad Dermatol 50 Suppl1 2004 38
47. R.F. Rose, and M.J. Goodfield Combining PUVA therapy with systemic immunosuppression to treat progressive diffuse morphoea Clin Exp Dermatol 30 2005 226 228
48. R. Roldan, G. Morote, C. Castro Mdel, M.D. Miranda, J.C. Moreno, and E. Collantes Efficacy of bosentan in treatment of unresponsive cutaneous ulceration in disabling pansclerotic morphea in children J Rheumatol 33 2006 2538 2540
49. M. Diab, M. Pilewskie, M. Bechtel, and G. Frambach Successful treatment of generalized morphea with infliximab: a case report J Am Acad Dermatol 56 Suppl 2 2007 AB66
50. P. Joly, N. Bamberger, B. Crickx, and S. Belaich Treatment of severe forms of localized scleroderma with oral corticosteroids: follow-up study on 17 patients Arch Dermatol 130 1994 663 664
51. S.H. Maragh, M.D. Davis, A.J. Bruce, and A.M. Nelson Disabling pansclerotic morphea: clinical presentation in two adults J Am Acad Dermatol 53 Suppl 2005 S115 S119
52. M. Mohrenschlager, C. Jung, J. Ring, and D. Abeck Effect of penicillin G on corium thickness in linear morphea of childhood: an analysis using ultrasound technique Pediatr Dermatol 16 1999 314 316
53. V. Falanga, and T.A. Medsger Jr. D-penicillamine in the treatment of localized scleroderma Arch Dermatol 126 1990 609 612
54. D. Eisen, and T.S. Alster Use of 585 nm pulsed dye laser for the treatment of morphea Dermatol Surg 28 2002 615 616
55. N.V. Kamath, A. Usmani, and A. Pellegrini When is surgical treatment not appropriate for morphea? Ann Plast Surg 45 2000 199 201
56. X.H. Nguyen, R. Hansen, and F. Valencia Severe ankle deformity secondary to pansclerotic morphea in a 9-year-old girl: correction involving arthrodesis and free flap coverage Pediatr Dermatol 19 2002 560 563
57. L.K. Martin, and R.S. Kirsner Ulcers caused by bullous morphea treated with tissue-engineered skin Int J Dermatol 42 2003 402 404
58. J. Braun, P. Kastner, P. Flaxenberg, J. Wahrisch, P. Hanke, and W. Demary Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial Arthritis Rheum 58 2008 73 81
59. A. Sinha, and A. Bagga Pulse steroid therapy Indian J Pediatr 75 2008 1057 1066
60. S. Ladhani The need for evidence-based management of skin diseases Int J Dermatol 36 1997 17 22