Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma

Thorax

Volumn 66, Issue 11, 2011, Pages 937-941

  Perrin, Kyle ^a,b   Wijesinghe, Meme ^a,b   Healy, Bridget ^a,b   Wadsworth, Kirsten ^a   Bowditch, Richard ^a,b   Bibby, Susan ^a,b   Baker, Tanya ^a   Weatherall, Mark ^b,c   Beasley, Richard ^a,b,c  

^a MEDICAL RESEARCH INSTITUTE OF NEW ZEALAND   (New Zealand)

^b CAPITAL AND COAST DISTRICT HEALTH BOARD   (New Zealand)

^c UNIVERSITY OF OTAGO WELLINGTON   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

ADULT; AGED; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; ASTHMA; CARBON DIOXIDE TENSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG DOSE TITRATION; DRUG MEGADOSE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HYPERCAPNIA; HYPOXEMIA; MAJOR CLINICAL STUDY; MALE; OXYGEN SATURATION; OXYGEN THERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK FACTOR; TRANSCUTANEOUS CARBON DIOXIDE MONITORING; TREATMENT OUTCOME;

EID: 80054113763     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2010.155259     Document Type: Article

References (39)

1. Westlake EK, Simpson T, Kaye M. Carbon dioxide narcosis in emphysema. Q J Med 1955;94:155-73.
2. Murphy R, Driscoll P, O'Driscoll R. Emergency oxygen therapy for the COPD patient. Emerg Med J 2001;18:332-9.
3. Aubier M, Murciano D, Fournier M, et al. Central respiratory drive in acute respiratory failure of patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1980;122:191-9. (Pubitemid 10087488)
4. 2 on ventilation and blood gases in patients with chronic obstructive pulmonary disease during acute respiratory failure. Am Rev Respir Dis 1980;122:747-54.
5. 2-induced change in ventilation and ventilatory drive in COPD. Am J Respir Crit Care Med 1997;155:609-14.
6. Robinson TD, Freiberg DB, Regnis JA, et al. The role of hypoventilation and ventilationeperfusion redistribution in oxygen-induced hypercapnia during acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000;161:1524-9. (Pubitemid 30329022)
7. Sassoon CS, Hassell KT, Mahutte CK. Hyperoxic-induced hypercapnia in stable chronic obstructive pulmonary disease. Am Rev Respir Dis 1987;135:907-11. (Pubitemid 17055522)
8. McFadden ER Jr, Lyons HA. Arterial-blood gas tension in asthma. N Engl J Med 1968;278:1027-32.
9. Ferrer A, Roca J, Wagner PD, et al. Airway obstruction and ventilationeperfusion relationships in acute severe asthma. Am Rev Respir Dis 1993;147:579-84. (Pubitemid 23072645)
10. Rodriguez-Roisin R, Ballester E, Roca J, et al. Mechanisms of hypoxemia in patients with status asthmaticus requiring mechanical ventilation. Am Rev Respir Dis 1989;139:732-9. (Pubitemid 19084398)
11. Ballester E, Reyes A, Roca J, et al. Ventilationeperfusion mismatching in acute severe asthma: effects of salbutamol and 100% oxygen. Thorax 1989;44:258-67. (Pubitemid 19113526)
12. Field GB. The effects of posture, oxygen, isoproterenol and atropine on ventilationeperfusion relationships in the lung in asthma. Clin Sci 1967;32:279-88.
13. Ballester E, Roca J, Ramis L, et al. Pulmonary gas exchange in severe chronic asthma. Response to 100% oxygen and salbutamol. Am Rev Respir Dis 1990;141:558-62. (Pubitemid 20109137)
14. Corte P, Young IH. Ventilationeperfusion relationships in symptomatic asthma. Response to oxygen and clemastine. Chest 1985;88:167-75. (Pubitemid 15004979)
15. Valabhji P. Gas exchange in the acute and asymptomatic phases of asthma breathing air and oxygen. Clin Sci 1968;34:431-40.
16. Beale HD, Schiller IW, Halperin MH, et al. Delirium and coma precipitated by oxygen in bronchial asthma complicated by respiratory acidosis. N Engl J Med 1951;244:710-14.
17. Simpson H, Forfar JO, Grubb DJ. Arterial blood gas tensions and pH in acute asthma in childhood. Br Med J 1968;3:460-4.
18. Chien JW, Ciufo R, Novak R, et al. Uncontrolled oxygen administration and respiratory failure in acute asthma. Chest 2000;117:728-33. (Pubitemid 30152212)
19. 2 and peak expiratory flow rate in acute asthma: a randomized trial. Chest 2003;124:1312-17.
20. Tai E, Read J. Blood-gas tensions in bronchial asthma. Lancet 1967;1:644-6.
21. Rudolf M, Turner JA, Harrison BD, et al. Changes in arterial blood gases during and after a period of oxygen breathing in patients with chronic hypercapnic respiratory failure and in patients with asthma. Clin Sci 1979;57:389-96. (Pubitemid 10094564)
22. Scottish Intercollegiate Guidelines Network and British Thoracic Society. British Guideline on the Management of Asthma: A National Clinical Guideline. 2009. http://www.sign.ac.uk/pdf/sign101.pdf.
23. Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143-78.
24. O'Driscoll BR, Howard LS, Davison AG; On behalf of the British Thoracic Society. BTS Guideline for emergency oxygen use in adult patients. Thorax 2008;63(Suppl vi):vi1-68.
25. Milross J, Young IH, Donnelly P. The oxygen delivery characteristics of the Hudson Oxy-one face mask. Anaesth Intensive Care 1989;17:180-4. (Pubitemid 19122517)
26. Garcia JA, Gardner D, Vines D, et al. The oxygen concentrations delivered by different oxygen therapy systems. Chest 2005;128:389S-90S.
27. Brown H, Prescott R. Applied Mixed Linear Models in Medicine. 2nd edn. Chichester: John Wiley & Sons, 2006.
28. 2 in healthy subjects. Respirology 2009;14:436-42.
29. 2 levels in patients using NIV for AECOPD. Thorax 2006;61:363-4.
30. Senn O, Clarenbach CF, Kaplan V, et al. Monitoring carbon dioxide tension and arterial oxygen saturation by a single earlobe sensor in patients with critical illness or sleep apnea. Chest 2005;128:1291-6. (Pubitemid 41324409)
31. Rodriguez P, Lellouche F, Aboab J, et al. Transcutaneous arterial carbon dioxide pressure monitoring in critically ill adult patients. Intensive Care Med 2006;32:309-12. (Pubitemid 43251154)
32. McVicar J, Eager R. Validation study of a transcutaneous carbon dioxide monitor in patients in the emergency department. Emerg Med J 2009;26:344-6.
33. Perrin K, Wijesinghe M, Weatherall M, et al. Assessing PaCO2 in acute respiratory disease: accuracy of a transcutaneous carbon dioxide device. Intern Med J 2011;41:585-646.
34. Stradling JR. Hyercapnia during oxygen therapy in airways obstruction: a reappraisal. Thorax 1986;41:897-902. (Pubitemid 17213097)
35. Barrera F, Hillyer P, Ascanio G, et al. The distribution of ventilation, diffusion, and blood flow in obese patients with normal and abnormal blood gases. Am Rev Respir Dis 1973;108:819-30.
36. Wijesinghe M, Williams M, Perrin K, et al. The effect of supplemental oxygen on hypercapnia in subjects with obesity-associated hypoventilation: a randomized cross-over clinical study. Chest 2011;139:1018-24.
37. Said SI, Banerjee CM. Venous admixture to the pulmonary circulation in human subjects breathing 100 per cent oxygen. J Clin Invest 1963;42:507-15.
38. Becker H, Polo O, McNamara S, et al. Effect of different levels of hyperoxia on breathing in healthy subjects. J Appl Physiol 1996;81:1683-90. (Pubitemid 26349626)
39. Iscoe S, Fisher JA. Hyperoxia-induced hypocapnia: an underappreciated risk. Chest 2005;128:430-3. (Pubitemid 40994505)