Pharmacokinetics of tilmicosin in beef cattle following intravenous and subcutaneous administration

Journal of Veterinary Pharmacology and Therapeutics

Volumn 34, Issue 6, 2011, Pages 583-587

  Lombardi, K R ^a   Portillo, T ^a   Hassfurther, R ^a   Hunter, R P ^a  

^a ELANCO ANIMAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TILMICOSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BEEF CATTLE; BODY WEIGHT; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG EXPOSURE; DRUG HALF LIFE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT DURATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL AVAILABILITY; BODY WEIGHT; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INFUSIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; TANDEM MASS SPECTROMETRY; TYLOSIN;

ANIMALIA; BOS;

EID: 80054100995     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2011.01268.x     Document Type: Article

References (7)

1. Herrerra, M., Ding, H., McClanahan, R., Owens, J. & Hunter, R.P. (2007) Quantitative Determination of tilmicosin in canine serum by high performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B., 875, 9-14.
2. Moredo, F., Diez, M., Perfumo, M. & Landoni, M.F. (2001) Pharmacokinetics and cardiotoxicity of tilmicosin after intravenous administration in pigs. Journal of the Caribbean Veterinary Medical Association, 1, 18-23.
3. Riviere, J.E. (1999). Comparative Pharmacokinetics Principles, Techniques, and Applications, pp. 156-158. Iowa University State Press, Ames, Iowa.
4. Scorneaux, B. & Shryock, T.R. (1999a) Intracellular Accumulation, Subcelular Distribution, and Efflux of Tilmicosin in Bovine Mammary, Blood, and Lung Cells. Journal of Diary Science, 82, 1202-1212.
5. Scorneaux, B. & Shryock, T.R. (1999b) The determination of the cellular volume of avian, porcine and bovine phagocytes and bovine mammary epithelial cells and its relationship to uptake of tilmicoisn. Journal of Veterinary Pharmacology and Therapeutics, 22, 6-12.
6. Thompson, T.D., Laudert, S.B., Chamberland, S. & Lawrence, K. (1994). Micotil-Pharmacokinetics of tilmicosin, a semi-synthetic macrolide antibiotic, in acutely pneumonic cattle and primary bovine alveolar macrophages. 6th EAVPT Congress, 31-32.
7. Ziv, G., Shem-Tov, M., Glickman, A., Winkler, M. & Saran, A. (1995) Tilmicosin antibacterialactivity and pharmacokinetics in cows. Journal of Veterinary Pharmacology and Therapeutics, 18, 340-345.