Stem cell therapy in cardiology

Regenerative Medicine

Volumn 6, Issue 6 SUPPL., 2011, Pages 17-23

  Choudry, Fizzah A ^a   Mathur, Anthony ^a  

^a LONDON CHEST HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO;

ACUTE HEART INFARCTION; ADIPOSE TISSUE DERIVED STEM CELL; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BIOENGINEERING; BONE MARROW MONONUCLEAR CELL; CARDIOLOGY; CD34+ STEM CELL; CELL POPULATION; CELL SELECTION; CELL THERAPY; CHRONIC ISCHEMIC HEART FAILURE; HEART FAILURE; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; HUMAN; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MONONUCLEAR CELL; MORTALITY; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVASCULARIZATION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STEM CELL; STEM CELL TRANSPLANTATION; TRANSENDOCARDIAL ALLOGENEIC MESENCHYMAL STEM CELL TRANSPLANTATION; TRANSLATIONAL RESEARCH;

CARDIOLOGY; CLINICAL TRIALS AS TOPIC; FEASIBILITY STUDIES; HUMANS; MYOCARDIAL ISCHEMIA; REGENERATIVE MEDICINE; STEM CELL TRANSPLANTATION;

EID: 80054099139     PISSN: 17460751     EISSN: 1746076X     Source Type: Journal    
DOI: 10.2217/rme.11.57     Document Type: Article

References (19)

1. Orlic D, Kajstura J, Chimenti S et al. Bone marrow cells regenerate infarcted myocardium. Nature 410, 701-705 (2001). □ Seminal and controversial paper showing myocardial regeneration using bone marrow-derived cells in a mouse model of acute myocardial ischemia.
2. Martin-Rendon E, Brunskill SJ, Hyde CJ et al. Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review. Eur. Heart J. 29, 1807-1818 (2008). □ Important meta-analysis using Cochrane methodology of clinical trials of bone marrow-derived cells in acute myocardial infarction, showing benefit of cell therapy on cardiac function.
3. Arnesen H, Lunde K, Aakhus S et al. Cell therapy in myocardial infarction. Lancet 369, 2142-2143 (2007).
4. Hirsch A, Robin Nijveldt R, van der Vleuten PA et al. Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood compared with standard therapy in patients after acute myocardial infarction treated by primary percutaneous coronary intervention: results of the randomized controlled HEBE trial. Eur. Heart J. 32(14), 1736-1747 (2011).
5. Wollert KC, Meyer GP, Lotz J et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 364, 141-148 (2004).
6. Meyer GP, Wollert KC, Lotz J et al. Intracoronary bone marrow cell transfer after myocardial infarction: 5-year followup from the randomized-controlled BOOST trial. Eur. Heart J. 30, 2978-2984 (2009).
7. Schachinger V, Erbs S, Elsasser A et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N. Engl. J. Med. 355, 1210-1221 (2006). □ Original report of REPAIR-AMI clinical trial that showed bone marrow-derived cell therapy improved cardiac function in acute myocardial infarction.
8. Reffelmann T, Konemann S, Kloner RA. Promise of blood-and bone marrowderived stem cell transplantation for functional cardiac repair: putting it in perspective with existing therapy. J. Am. Coll. Cardiol. 53, 305-308 (2009). □ Retrospective demonstration of how landmark trials in clinical practice with proven mortality/morbidity benefits show changes in cardiac function similar to that seen in trials of cell therapy.
9. Strauer BE, Yousef M, Schannwell CM. The acute and long-term effects of intracoronary stem cell transplantation in 191 patients with chronic heart failure: the STAR-heart study. Eur. J. Heart Fail. 12, 721-729 (2010).
10. Perin EC, Silva GV, Henry TD et al. A randomized study of transendocardial injection of autologous bone marrow mononuclear cells and cell function analysis in ischemic heart failure (FOCUS-HF). Am. Heart J. 161, 1078-1087. e3 (2011).
11. van Ramshorst J, Bax JJ, Beeres SL et al. Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial. JAMA 301, 1997-2004 (2009).
12. Tse HF, Thambar S, Kwong YL et al. Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial). Eur. Heart J. 28, 2998-3005 (2007).
13. Friis T, Haack-Sorensen M, Mathiasen AB et al. Mesenchymal stromal cell derived endothelial progenitor treatment in patients with refractory angina. Scand. Cardiovasc. J. 45, 161-168 (2011).
14. Tendera M, Wojakowski W, Ruzyłło W et al. Intracoronary infusion of bone marrow-derived selected CD341CXCR41 cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) trial. Eur. Heart J. 30(11), 1313-1321 (2009).
15. Meliga E, Strem BM, Duckers HJ et al. Adipose-derived cells. Cell Transplant. 16, 963-970 (2007).
16. Hare JM, Traverse JH, Henry TD et al. A randomized, double-blind, placebocontrolled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J. Am. Coll. Cardiol. 54, 2277-2286 (2009).
17. Williams AR, Trachtenberg B, Velazquez DL et al. Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling. Circ. Res. 108, 792-796 (2011).
18. Badylak SF, Taylor D, Uygun K. Wholeorgan tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds. Annu. Rev. Biomed. Eng. 13, 27-53 (2010).
19. Smart N, Bollini S, Dube KN et al. De novo cardiomyocytes from within the activated adult heart after injury. Nature 474(7353), 640-644 (2011). □ Exciting preclinical data suggesting therapeutic potential of resident cardiac progenitor cell pool.